{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363667548357661696.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.dmpk.2021.100403"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1347436721000240?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1347436721000240?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"34619548"}},{"identifier":{"@type":"NAID","@value":"210000185306"}}],"dc:title":[{"@value":"Reduced theophylline clearance due to hepatic congestion secondary to right heart failure - A population pharmacokinetic study"}],"description":[{"notation":[{"@value":"Theophylline, a beneficial drug with bronchodilatory and anti-inflammatory effects, is used for the treatment of respiratory diseases. Pulmonary (PC) and hepatic congestion (HC) are secondary to the development of left- and right-sided heart failure (HF), respectively. This study aimed to evaluate the effects of PC and HC on theophylline clearance (CL) by population pharmacokinetic (PPK) analysis with consideration of the severity of HF assessed by the New York Heart Association (NYHA) functional classification. We obtained 710 minimum steady-state concentrations from 201 Japanese bronchial asthma patients with and without HF. PPK analysis was performed by NONMEM. In the analysis, the left ventricular ejection fraction, smoking (SMK), clarithromycin (CAM), sex, and age were also considered as covariates. The final model of apparent theophylline clearance (CL/F) was as follows: CL/F (L/hr/kg) = 0.0465 × 1.40"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1581135807999906689","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000415224724"}],"foaf:name":[{"@value":"Yasuo Kurata"}]},{"@id":"https://cir.nii.ac.jp/crid/1581135807999906691","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000415224725"}],"foaf:name":[{"@value":"Shota Muraki"}]},{"@id":"https://cir.nii.ac.jp/crid/1581135807999906688","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000415224726"}],"foaf:name":[{"@value":"Takeshi Hirota"}]},{"@id":"https://cir.nii.ac.jp/crid/1581135807999906690","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000415224727"}],"foaf:name":[{"@value":"Hiroshi Araki"}]},{"@id":"https://cir.nii.ac.jp/crid/1581135807999906692","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000415224728"}],"foaf:name":[{"@value":"Ichiro Ieiri"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13474367"}],"prism:publicationName":[{"@value":"Drug Metabolism and Pharmacokinetics"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2021-12","prism:volume":"41","prism:startingPage":"100403"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S1347436721000240?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S1347436721000240?httpAccept=text/plain"}],"createdAt":"2021-05-03","modifiedAt":"2025-10-22","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Heart%20Failure","dc:title":"Heart Failure"},{"@id":"https://cir.nii.ac.jp/all?q=Kinetics","dc:title":"Kinetics"},{"@id":"https://cir.nii.ac.jp/all?q=Theophylline","dc:title":"Theophylline"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Stroke%20Volume","dc:title":"Stroke Volume"},{"@id":"https://cir.nii.ac.jp/all?q=Ventricular%20Function,%20Left","dc:title":"Ventricular Function, Left"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144927821568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Theophylline in the management of asthma: time for reappraisal?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145064867968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of smoking on theophylline disposition"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306506836443776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of chronic left ventricular failure on hepatic oxygenation and theophylline elimination in the rat."}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095574193152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Theophylline—an Immunomodulatory Role in Asthma?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095650424960","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Theophylline Metabolism by Human, Rabbit and Rat Liver Microsomes and by Purified Forms of Cytochrome P450"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095663921152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Theophylline elimination in congestive heart failure"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096286901376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical Pharmacokinetics of Drugs in Patients with Heart Failure"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568682304640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypoxia‐induced down‐regulation of CYP1A1/1A2 and up‐regulation of CYP3A6 involves serum mediators"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569639118592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pharmacokinetic interaction between theophylline and erythromycin."}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569640843008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immunomodulation by Theophylline in Asthma. 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II. Intravenous Infusion to Patients with Stable Chronic Airway Obstruction."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206434330496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Analysis of acute and chronic heart failure in view of hepatic oxygen supply-demand relationship using hepatic venous oxygen saturation."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679598385024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Population Pharmacokinetics of Theophylline. III. Premarketing Study for a Once-Daily Administered Preparation."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680080429696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Guidelines for Treatment of Acute Heart Failure (JCS 2011)"},{"@value":"Guidelines for treatment of acute heart failure (JCS 2011): digest version"}]},{"@id":"https://cir.nii.ac.jp/crid/1390564227306263808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure　― Digest Version ―"},{"@value":"JCS GUIDELINES : JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure : Digest Version"},{"@value":"Japanese Circulation Society and the Japanese Heart Failure Society Joint Working Group. JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure- Digest Version"},{"@value":"JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure—Digest Version"},{"@value":"JCS 2017/JHFS 2017 Guideline on diagnosis and treatment of acute and chronic heart failure — digest version —"},{"@value":"JCS 2017/JHFS 2017 guideline on diagnosis and treatment of acute and chronic heart failure"},{"@value":"JCS 2017/JHFS 2017 guideline on diagnosis and treatment of acute and chronic heart failure- digest version. JCS 2017/JHFS 2017 guideline on diagnosis and treatment of acute and chronic heart failure- digest version"},{"@value":"Japanese Circulation Society and the Japanese Heart Failure Society Joint Working Group. JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure—Digest Version"},{"@value":"Japanese Circulation Society and the Japanese Heart Failure Society Joint Working Group. Guidelines for diagnosis and treatment of acute and chronic heart failure"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.dmpk.2021.100403"},{"@type":"CIA","@value":"210000185306"},{"@type":"OPENAIRE","@value":"doi_dedup___::175701215ada9f718edf3cace6c79d30"}]}