{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670318198207488.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.0605938103"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.0605938103"}}],"dc:title":[{"@value":"Conservation and evolution of gene coexpression networks in human and chimpanzee brains"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Comparisons of gene expression between human and non-human primate brains have identified hundreds of differentially expressed genes, yet translating these lists into key functional distinctions between species has proved difficult. Here we provide a more integrated view of human brain evolution by examining the large-scale organization of gene coexpression networks in human and chimpanzee brains. We identify modules of coexpressed genes that correspond to discrete brain regions and quantify their conservation between the species. Module conservation in cerebral cortex is significantly weaker than module conservation in subcortical brain regions, revealing a striking gradient that parallels known evolutionary hierarchies. We introduce a method for identifying species-specific network connections and demonstrate how differential network connectivity can be used to identify key drivers of evolutionary change. By integrating our results with comparative genomic sequence data and estimates of protein sequence divergence rates, we confirm a number of network predictions and validate these findings. Our results provide insights into the molecular bases of primate brain organization and demonstrate the general utility of weighted gene coexpression network analysis.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380294723342028674","@type":"Researcher","foaf:name":[{"@value":"Michael C. Oldham"}],"jpcoar:affiliationName":[{"@value":"*Interdepartmental Program for Neuroscience,"},{"@value":"Neurology, Program in Neurogenetics, and"},{"@value":"Semel Institute, David Geffen School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095-6814"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294723342028672","@type":"Researcher","foaf:name":[{"@value":"Steve Horvath"}],"jpcoar:affiliationName":[{"@value":"Departments of §Biostatistics,"},{"@value":"Human Genetics, and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294723342028673","@type":"Researcher","foaf:name":[{"@value":"Daniel H. Geschwind"}],"jpcoar:affiliationName":[{"@value":"Human Genetics, and"},{"@value":"Neurology, Program in Neurogenetics, and"},{"@value":"Semel Institute, David Geffen School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095-6814"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"2006-11-21","prism:volume":"103","prism:number":"47","prism:startingPage":"17973","prism:endingPage":"17978"},"reviewed":"false","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.0605938103"}],"createdAt":"2006-11-13","modifiedAt":"2022-04-12","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050845760790505984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Human-specific features of spatial gene expression and regulation in eight brain regions"}]},{"@id":"https://cir.nii.ac.jp/crid/1050848249868400000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Genomic adaptations to aquatic and aerial life in mayflies and the origin of insect wings"}]},{"@id":"https://cir.nii.ac.jp/crid/1050869456406262656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Vocal practice regulates singing activity-dependent genes underlying age-independent vocal learning in songbirds"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004234740019456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"ATTED-II in 2016: A Plant Coexpression Database Towards Lineage-Specific Coexpression"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232154634752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>CBNplot</i>: Bayesian network plots for enrichment analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846642062837632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Comparative transcriptomics reveals patterns of selection in domesticated and wild tomato"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1073/pnas.0605938103"},{"@type":"CROSSREF","@value":"10.1093/pcp/pcv165_references_DOI_YgyK8pXGJohdpuzjoqJghaRNGBx"},{"@type":"CROSSREF","@value":"10.1101/gr.231357.117_references_DOI_YgyK8pXGJohdpuzjoqJghaRNGBx"},{"@type":"CROSSREF","@value":"10.1371/journal.pbio.2006537_references_DOI_YgyK8pXGJohdpuzjoqJghaRNGBx"},{"@type":"CROSSREF","@value":"10.1038/s41467-020-16284-8_references_DOI_YgyK8pXGJohdpuzjoqJghaRNGBx"},{"@type":"CROSSREF","@value":"10.1093/bioinformatics/btac175_references_DOI_YgyK8pXGJohdpuzjoqJghaRNGBx"},{"@type":"CROSSREF","@value":"10.1073/pnas.1309606110_references_DOI_YgyK8pXGJohdpuzjoqJghaRNGBx"}]}