{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670318202050304.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1128/jcm.33.9.2435-2444.1995"}},{"identifier":{"@type":"URI","@value":"https://journals.asm.org/doi/pdf/10.1128/jcm.33.9.2435-2444.1995"}}],"dc:title":[{"@value":"Comparison of MICs of ceftiofur and other antimicrobial agents against bacterial pathogens of swine from the United States, Canada, and Denmark"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The MICs of ceftiofur and other antimicrobial agents, tested for comparison, for 515 bacterial isolates of pigs from the United States, Canada, and Denmark with various diseases were compared. The organisms tested included Actinobacillus pleuropneumoniae, Escherichia coli, Pasteurella multocida, Salmonella choleraesuis, Salmonella typhimurium, Streptococcus suis, Streptococcus dysgalactiae subsp. equisimilis, Streptococcus equi subsp. equi, and Streptococcus equi subsp. zooepidemicus. In addition to ceftiofur, the following antimicrobial agents or combinations were tested: enrofloxacin, ampicillin, sulfamethazine, trimethoprim-sulfadiazine (1:19), erythromycin, lincomycin, spectinomycin, lincomycin-spectinomycin (1:8), tilmicosin, and tetracycline. Tilmicosin was only tested against the U.S. isolates. Overall, ceftiofur and enrofloxacin were the most active antimicrobial agents tested against all isolates, with MICs inhibiting 90% of isolates tested (MIC90s) of < or = 2.0 and < or = 1.0 microgram/ml, respectively. Erythromycin, sulfamethazine, spectinomycin, and lincomycin demonstrated limited activity against all of the organisms tested, with MIC90s of > or = 8.0, > or = 256.0, > or = 32.0, and > or = 16.0 micrograms/ml, respectively. Trimethoprim-sulfadiazine was active against isolates of A. pleuropneumoniae, S. choleraesuis, S. typhimurium, P. multocida, S. equi, and S. suis (MIC90s, < or = 0.5 microgram/ml) but was less active against the E. coli strains tested (MIC90, > 16.0 micrograms/ml). Ampicillin was active against the P. multocida, S. suis, and S. equi isolates tested (MIC90s, 0.5, 0.06, and 0.06 micrograms/ml, respectively) and was moderately active against S. typhimurium (MIC90s, 2.0 micrograms/ml). However, this antimicrobial agent was much less active when it was tested against A. pleuropneumoniae, S. cholerae-suis, and E. coli (MIC90s, 16.0, > 32.0, and 32.0 micrograms/ml, respectively). Against the U.S. isolates of A. pleuropneumoniae and P. multocida, tilmicosin was moderately active (MIC90s, 4.0 and 8.0 micrograms/ml, respectively). However, this compound was not active against the remaining U.S. isolates (MIC90s, > 64.0 micrograms/ml). Differences in the MICs from one country to another were not detected with enrofloxacin, ceftiofur, or lincomycin for the strains tested, but variations in the MICs of the remaining antimicrobial agents were observed.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670318202050304","@type":"Researcher","foaf:name":[{"@value":"S A Salmon"}],"jpcoar:affiliationName":[{"@value":"Upjohn Company, Kalamazoo, Michigan 49001, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318202050305","@type":"Researcher","foaf:name":[{"@value":"J L Watts"}],"jpcoar:affiliationName":[{"@value":"Upjohn Company, Kalamazoo, Michigan 49001, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318202050306","@type":"Researcher","foaf:name":[{"@value":"C A Case"}],"jpcoar:affiliationName":[{"@value":"Upjohn Company, Kalamazoo, Michigan 49001, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318202050432","@type":"Researcher","foaf:name":[{"@value":"L J Hoffman"}],"jpcoar:affiliationName":[{"@value":"Upjohn Company, Kalamazoo, Michigan 49001, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318202050434","@type":"Researcher","foaf:name":[{"@value":"H C Wegener"}],"jpcoar:affiliationName":[{"@value":"Upjohn Company, Kalamazoo, Michigan 49001, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318202050433","@type":"Researcher","foaf:name":[{"@value":"R J Yancey"}],"jpcoar:affiliationName":[{"@value":"Upjohn Company, Kalamazoo, Michigan 49001, USA."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00951137"},{"@type":"EISSN","@value":"1098660X"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00951137"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/00951137"}],"prism:publicationName":[{"@value":"Journal of Clinical Microbiology"}],"dc:publisher":[{"@value":"American Society for Microbiology"}],"prism:publicationDate":"1995-09","prism:volume":"33","prism:number":"9","prism:startingPage":"2435","prism:endingPage":"2444"},"reviewed":"false","dc:rights":["https://journals.asm.org/non-commercial-tdm-license"],"url":[{"@id":"https://journals.asm.org/doi/pdf/10.1128/jcm.33.9.2435-2444.1995"}],"createdAt":"2020-01-06","modifiedAt":"2022-03-05","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001206427445888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Antimicrobial Susceptibility of Pathogenic Escherichia coli Isolated from Pigs in Korea."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681401148160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of Enrofloxacin-Na against Pathogens Related to the Respiratory and Alimentary Diseases in Suckling and Weanling Piglets."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681401652224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Antimicrobial Susceptibility of Actinobacillus pleuropneumoniae Isolated from Pigs in Korea Using New Standardized Procedures."}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1128/jcm.33.9.2435-2444.1995"},{"@type":"CROSSREF","@value":"10.1292/jvms.64.71_references_DOI_CoGvMyLy6ERxcdoKd8LLElyVhO"},{"@type":"CROSSREF","@value":"10.1292/jvms.63.67_references_DOI_CoGvMyLy6ERxcdoKd8LLElyVhO"},{"@type":"CROSSREF","@value":"10.1292/jvms.63.341_references_DOI_CoGvMyLy6ERxcdoKd8LLElyVhO"}]}