{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670318243295488.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3748/wjg.v18.i19.2300"}},{"identifier":{"@type":"PMID","@value":"22654421"}}],"dc:title":[{"@value":"Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis"}],"description":[{"notation":[{"@value":"Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in the liver of a patient without a history of alcohol abuse. Nonalcoholic steatohepatitis (NASH), a severe form of NAFLD, can progress to liver cirrhosis and hepatocellular carcinoma. NAFLD is regarded as a hepatic manifestation of metabolic syndrome and incidence has been increasing worldwide in line with the increased prevalence of obesity, type 2 diabetes, and hyperlipemia. Animal models of NAFLD/NASH give crucial information, not only in elucidating pathogenesis of NAFLD/NASH but also in examining therapeutic effects of various agents. An ideal model of NAFLD/NASH should correctly reflect both hepatic histopathology and pathophysiology of human NAFLD/NASH. Animal models of NAFLD/NASH are divided into genetic, dietary, and combination models. In this paper, we review commonly used animal models of NAFLD/NASH referring to their advantages and disadvantages."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670318243295488","@type":"Researcher","foaf:name":[{"@value":"Yoshihisa Takahashi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10079327"}],"prism:publicationName":[{"@value":"World Journal of Gastroenterology"}],"dc:publisher":[{"@value":"Baishideng Publishing Group Inc."}],"prism:publicationDate":"2012","prism:volume":"18","prism:number":"19","prism:startingPage":"2300"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","createdAt":"2012-05-15","modifiedAt":"2012-05-15","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Metabolic%20Syndrome","dc:title":"Metabolic Syndrome"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Transgenic","dc:title":"Mice, Transgenic"},{"@id":"https://cir.nii.ac.jp/all?q=Diet,%20High-Fat","dc:title":"Diet, High-Fat"},{"@id":"https://cir.nii.ac.jp/all?q=Fatty%20Liver","dc:title":"Fatty Liver"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Liver","dc:title":"Liver"},{"@id":"https://cir.nii.ac.jp/all?q=Non-alcoholic%20Fatty%20Liver%20Disease","dc:title":"Non-alcoholic Fatty Liver Disease"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Diet,%20Atherogenic","dc:title":"Diet, Atherogenic"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282677525475328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Novel non-alcoholic steatohepatitis model with histopathological and insulin-resistant features"},{"@value":"Novel non‐alcoholic steatohepatitis model with histopathological and 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