{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670318300587776.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1242/dmm.009282"}},{"identifier":{"@type":"URI","@value":"http://journals.biologists.com/dmm/article-pdf/6/3/580/1865734/580.pdf"}}],"dc:title":[{"@value":"Caught in the act: revealing the metastatic process by live imaging"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The prognosis of metastatic cancer in patients is poor. Interfering with metastatic spread is therefore important for achieving better survival from cancer. Metastatic disease is established through a series of steps, including breaching of the basement membrane, intravasation and survival in lymphatic or blood vessels, extravasation, and growth at distant sites. Yet, although we know the steps involved in metastasis, the cellular and molecular mechanisms of dissemination and colonization of distant organs are incompletely understood. Here, we review the important insights into the metastatic process that have been gained specifically through the use of imaging technologies in murine, chicken embryo and zebrafish model systems, including high-resolution two-photon microscopy and bioluminescence. We further discuss how imaging technologies are beginning to allow researchers to address the role of regional activation of specific molecular pathways in the metastatic process. These technologies are shedding light, literally, on almost every step of the metastatic process, particularly with regards to the dynamics and plasticity of the disseminating cancer cells and the active participation of the microenvironment in the processes.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670318300587777","@type":"Researcher","foaf:name":[{"@value":"Miriam R. Fein"}],"jpcoar:affiliationName":[{"@value":"Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA"},{"@value":"Stony Brook University, Graduate Program in Genetics, 130 Life Sciences Building, Stony Brook, NY 11794, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318300587776","@type":"Researcher","foaf:name":[{"@value":"Mikala Egeblad"}],"jpcoar:affiliationName":[{"@value":"Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"17548411"},{"@type":"PISSN","@value":"17548403"}],"prism:publicationName":[{"@value":"Disease Models & Mechanisms"}],"dc:publisher":[{"@value":"The Company of Biologists"}],"prism:publicationDate":"2013-05-01","prism:volume":"6","prism:number":"3","prism:startingPage":"580","prism:endingPage":"593"},"reviewed":"false","url":[{"@id":"http://journals.biologists.com/dmm/article-pdf/6/3/580/1865734/580.pdf"}],"createdAt":"2013-04-24","modifiedAt":"2021-04-25","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282810817901568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Intravital Förster resonance energy transfer imaging reveals osteopontin-mediated polymorphonuclear leukocyte activation by tumor cell emboli"},{"@value":"Intravital Förster resonance energy transfer imaging reveals osteopontin‐mediated polymorphonuclear leukocyte activation by tumor cell emboli"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233476859776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Intubation-free in vivo imaging of the tracheal mucosa using two-photon microscopy"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1242/dmm.009282"},{"@type":"CROSSREF","@value":"10.1111/cas.13132_references_DOI_LBaXqyfP1pMJb7YsDqyHYvDdExy"},{"@type":"CROSSREF","@value":"10.1038/s41598-017-00769-6_references_DOI_LBaXqyfP1pMJb7YsDqyHYvDdExy"}]}