{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670318524872704.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/nph.12142"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fnph.12142"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/nph.12142"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/nph.12142"}},{"identifier":{"@type":"URI","@value":"https://nph.onlinelibrary.wiley.com/doi/pdf/10.1111/nph.12142"}}],"dc:title":[{"@value":"Regulation of flavonoid biosynthesis involves an unexpected complex transcriptional regulation of <i><scp>TT</scp>8</i> expression, in <scp>A</scp>rabidopsis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Summary</jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">TT</jats:styled-content>8</jats:italic>/<jats:italic>b<jats:styled-content style=\"fixed-case\">HLH</jats:styled-content>042</jats:italic> is a key regulator of anthocyanins and proanthocyanidins (<jats:styled-content style=\"fixed-case\">PA</jats:styled-content>s) biosynthesis in <jats:italic><jats:styled-content style=\"fixed-case\">A</jats:styled-content>rabidopsis thaliana</jats:italic>. <jats:styled-content style=\"fixed-case\">TT</jats:styled-content>8 transcriptional activity has been studied extensively, and relies on its ability to form, with several <jats:styled-content style=\"fixed-case\">R</jats:styled-content>2<jats:styled-content style=\"fixed-case\">R</jats:styled-content>3‐<jats:styled-content style=\"fixed-case\">MYB</jats:styled-content> and <jats:styled-content style=\"fixed-case\">TTG</jats:styled-content>1 (<jats:styled-content style=\"fixed-case\">WD</jats:styled-content>‐<jats:styled-content style=\"fixed-case\">R</jats:styled-content>epeat protein), different <jats:styled-content style=\"fixed-case\">MYB</jats:styled-content>‐<jats:styled-content style=\"fixed-case\">bHLH</jats:styled-content>‐<jats:styled-content style=\"fixed-case\">WDR</jats:styled-content> (<jats:styled-content style=\"fixed-case\">MBW</jats:styled-content>) protein complexes. By contrast, little is known on how <jats:italic><jats:styled-content style=\"fixed-case\">TT</jats:styled-content>8</jats:italic> expression is itself regulated.</jats:p></jats:list-item>\n\n<jats:list-item><jats:p>Transcriptional regulation of <jats:italic><jats:styled-content style=\"fixed-case\">TT</jats:styled-content>8</jats:italic> expression was studied using molecular, genetic and biochemical approaches.</jats:p></jats:list-item>\n\n<jats:list-item><jats:p>Functional dissection of the <jats:italic><jats:styled-content style=\"fixed-case\">TT</jats:styled-content>8</jats:italic> promoter revealed its modular structure. Two modules were found to specifically drive <jats:italic><jats:styled-content style=\"fixed-case\">TT</jats:styled-content>8</jats:italic> promoter activity in <jats:styled-content style=\"fixed-case\">PA</jats:styled-content>‐ and anthocyanin‐accumulating cells, by differentially integrating the signals issued from different regulators, in a spatio‐temporal manner. Interestingly, this regulation involves at least six different <jats:styled-content style=\"fixed-case\">MBW</jats:styled-content> complexes, and an unpredicted positive feedback regulatory loop between <jats:italic><jats:styled-content style=\"fixed-case\">TT</jats:styled-content>8</jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">TTG</jats:styled-content>2</jats:italic>. Moreover, the results suggest that some putative new regulators remain to be discovered. Finally, specific <jats:italic>cis</jats:italic>‐regulatory elements through which <jats:italic><jats:styled-content style=\"fixed-case\">TT</jats:styled-content>8</jats:italic> expression is regulated were identified and characterized.</jats:p></jats:list-item>\n\n<jats:list-item><jats:p>Together, these results provide a molecular model consistent with the specific and highly regulated expression of <jats:italic><jats:styled-content style=\"fixed-case\">TT</jats:styled-content>8</jats:italic>. They shed new light into the transcriptional regulation of flavonoid biosynthesis and provide new clues and tools for further investigation in <jats:styled-content style=\"fixed-case\">A</jats:styled-content>rabidopsis and other plant species.</jats:p></jats:list-item>\n</jats:list>\n</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670318524872708","@type":"Researcher","foaf:name":[{"@value":"Wenjia Xu"}],"jpcoar:affiliationName":[{"@value":"INRA Institut Jean‐Pierre Bourgin Saclay Plant Sciences UMR1318 RD10 F–78026 Versailles France"},{"@value":"AgroParisTech Institut Jean‐Pierre Bourgin Saclay Plant Sciences UMR1318 RD10 F–78026 Versailles France"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318524872709","@type":"Researcher","foaf:name":[{"@value":"Damaris Grain"}],"jpcoar:affiliationName":[{"@value":"INRA Institut Jean‐Pierre Bourgin Saclay Plant Sciences UMR1318 RD10 F–78026 Versailles France"},{"@value":"AgroParisTech Institut Jean‐Pierre Bourgin Saclay Plant 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