{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670318620731392.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/0024-3205(92)90406-f"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:002432059290406F?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:002432059290406F?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"1635419"}}],"dc:title":[{"@value":"Effects of (S) - α -fluoromethylhistidine and metoprine on locomotor activity and brain histamine content in mice"}],"description":[{"notation":[{"@value":"We examined the effects of (S)-alpha -fluoromethylhistidine (FMH), an inhibitor of histidine decarboxylase, and metoprine, an inhibitor of histamine N-methyltransferase, on the locomotor activity and the brain histamine content of ICR mice. The brain histamine content was decreased by FMH (12.5 or 50 mg/kg, i.p.) and increased by metoprine (4 mg/kg, i.p.). Under these conditions, the locomotor activity and the number of rearing were significantly decreased and increased by FMH and metoprine, respectively. The higher the brain histamine content, the greater the locomotor activity and vice versa. In a previous paper [Sakai et al., Life Sciences, 48, 2397-2404 (1991)], we showed that thioperamide, a histamine H3 antagonist, which enhances the release of histamine from histaminergic neurons, in doses of 12.5 and 25 mg/kg, i.p. increases the locomotor activity, whereas it decreases the brain histamine content. Taken together, these results support the hypothesis that central histaminergic neurons may be involved in the control of state of locomotion and rearing."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670318620731396","@type":"Researcher","foaf:name":[{"@value":"Naruhiko Sakai"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318620731394","@type":"Researcher","foaf:name":[{"@value":"Kenji Onodera"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318620731393","@type":"Researcher","foaf:name":[{"@value":"Kazutaka Maeyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318620731392","@type":"Researcher","foaf:name":[{"@value":"Kazuhiko Yanai"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318620731395","@type":"Researcher","foaf:name":[{"@value":"Takehiko Watanabe"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00243205"}],"prism:publicationName":[{"@value":"Life Sciences"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"1992","prism:volume":"51","prism:number":"6","prism:startingPage":"397","prism:endingPage":"405"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:002432059290406F?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:002432059290406F?httpAccept=text/plain"}],"createdAt":"2002-12-14","modifiedAt":"2025-11-02","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Brain%20Chemistry","dc:title":"Brain Chemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Histamine%20N-Methyltransferase","dc:title":"Histamine N-Methyltransferase"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20ICR","dc:title":"Mice, Inbred ICR"},{"@id":"https://cir.nii.ac.jp/all?q=Behavior,%20Animal","dc:title":"Behavior, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Histidine%20Decarboxylase","dc:title":"Histidine Decarboxylase"},{"@id":"https://cir.nii.ac.jp/all?q=Motor%20Activity","dc:title":"Motor Activity"},{"@id":"https://cir.nii.ac.jp/all?q=Methylhistidines","dc:title":"Methylhistidines"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Pyrimethamine","dc:title":"Pyrimethamine"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Injections,%20Intraperitoneal","dc:title":"Injections, Intraperitoneal"},{"@id":"https://cir.nii.ac.jp/all?q=Histamine","dc:title":"Histamine"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002220830462336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Insufficient Intake of L-Histidine Reduces Brain Histamine and Causes Anxiety-Like Behaviors in Male Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643853965952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Metoprine, a histamine N-methyltransferase inhibitor, attenuates methamphetamine-induced hyperlocomotion via activation of histaminergic neurotransmission in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565170906758016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Brain Histamine<i>N</i>-Methyltransferase as a Possible Target of Treatment for Methamphetamine Overdose"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232418196224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Are Histamine H3 Antagonists the Definitive Treatment for Acute Methamphetamine\nIntoxication?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846642074809728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Structural Study Reveals That Ser-354 Determines Substrate Specificity on Human Histidine Decarboxylase"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593692849792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Chemogenetic modulation of histaminergic neurons in the tuberomamillary nucleus alters territorial aggression and wakefulness"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204272611200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Towards Understanding Mechanisms of Drug Action and Functions of the Body on the Molecular Level. Studies on histamine with L-histidine decarboxylase, a histamine-forming enzyme, as a probe: from purification to gene knockout."},{"@language":"ja","@value":"薬の作用機序と生体機能の分子的理解に向けて　　ヒスタミンに関する研究　　ヒスチジン脱炭酸酵素の精製から欠損マウスまで"},{"@value":"ヒスタミンに関する研究:ヒスチジン脱炭酸酵素の精製から欠損マウスまで"},{"@language":"ja-Kana","@value":"ヒスタミン ニ カンスル ケンキュウ ヒスチジン ダツタンサン コウソ ノ セイセイ カラ ケッソン マウス マデ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205250364416","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Contribution of Histamine Type-1 Receptor to Metabolic and Behavioral Control of Ventilation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206479196160","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of a Chicken Extract on Food-Deprived Activity Stress in Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390858829321829632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Neurotoxicity and behavioral disorders induced in mice by acute exposure to          the diamide insecticide chlorantraniliprole"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/0024-3205(92)90406-f"},{"@type":"OPENAIRE","@value":"doi_dedup___::f079b9d72aac70ed874166a46e272455"},{"@type":"CROSSREF","@value":"10.3945/jn.114.196105_references_DOI_Am9QHuN46eT3TzQS6OxZcg43rnU"},{"@type":"CROSSREF","@value":"10.1271/bbb.90950_references_DOI_Am9QHuN46eT3TzQS6OxZcg43rnU"},{"@type":"CROSSREF","@value":"10.1254/fpj.118.159_references_DOI_Am9QHuN46eT3TzQS6OxZcg43rnU"},{"@type":"CROSSREF","@value":"10.1016/j.pbb.2021.173257_references_DOI_Am9QHuN46eT3TzQS6OxZcg43rnU"},{"@type":"CROSSREF","@value":"10.4137/dti.s38342_references_DOI_Am9QHuN46eT3TzQS6OxZcg43rnU"},{"@type":"CROSSREF","@value":"10.2170/physiolsci.rp006506_references_DOI_Am9QHuN46eT3TzQS6OxZcg43rnU"},{"@type":"CROSSREF","@value":"10.1292/jvms.23-0041_references_DOI_Am9QHuN46eT3TzQS6OxZcg43rnU"},{"@type":"CROSSREF","@value":"10.2174/2589977514666220414122847_references_DOI_Am9QHuN46eT3TzQS6OxZcg43rnU"},{"@type":"CROSSREF","@value":"10.1074/jbc.m112.381897_references_DOI_Am9QHuN46eT3TzQS6OxZcg43rnU"},{"@type":"CROSSREF","@value":"10.1038/s41598-021-95497-3_references_DOI_40aigb49mfMI9Dlh9MVKcGI1gOA"}]}