{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670318920291840.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.ccr.2014.04.021"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1535610814001846?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1535610814001846?httpAccept=text/plain"}}],"dc:title":[{"@value":"Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670318920291843","@type":"Researcher","foaf:name":[{"@value":"Andrew D. Rhim"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318920291714","@type":"Researcher","foaf:name":[{"@value":"Paul E. Oberstein"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318920291713","@type":"Researcher","foaf:name":[{"@value":"Dafydd H. Thomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318920291712","@type":"Researcher","foaf:name":[{"@value":"Emily T. Mirek"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318920291841","@type":"Researcher","foaf:name":[{"@value":"Carmine F. Palermo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318920291844","@type":"Researcher","foaf:name":[{"@value":"Stephen A. Sastra"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318920291840","@type":"Researcher","foaf:name":[{"@value":"Erin N. Dekleva"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318920291715","@type":"Researcher","foaf:name":[{"@value":"Tyler Saunders"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318920291716","@type":"Researcher","foaf:name":[{"@value":"Claudia P. Becerra"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318920291849","@type":"Researcher","foaf:name":[{"@value":"Ian W. Tattersall"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318920291842","@type":"Researcher","foaf:name":[{"@value":"C. Benedikt Westphalen"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318920291845","@type":"Researcher","foaf:name":[{"@value":"Jan Kitajewski"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318920291717","@type":"Researcher","foaf:name":[{"@value":"Maite G. Fernandez-Barrena"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318920291718","@type":"Researcher","foaf:name":[{"@value":"Martin E. Fernandez-Zapico"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318920291846","@type":"Researcher","foaf:name":[{"@value":"Christine Iacobuzio-Donahue"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318920291847","@type":"Researcher","foaf:name":[{"@value":"Kenneth P. Olive"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670318920291848","@type":"Researcher","foaf:name":[{"@value":"Ben Z. Stanger"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"15356108"}],"prism:publicationName":[{"@value":"Cancer Cell"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2014-06","prism:volume":"25","prism:number":"6","prism:startingPage":"735","prism:endingPage":"747"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/open-access/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S1535610814001846?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S1535610814001846?httpAccept=text/plain"}],"createdAt":"2014-05-22","modifiedAt":"2022-04-03","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050012570393987200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Gemcitabine Enhances Kras-MEK-Induced Matrix Metalloproteinase-10 Expression Via Histone Acetylation in Gemcitabine-Resistant Pancreatic Tumor-initiating Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1050013087466744064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Fibroblast heterogeneity and tertiary lymphoid tissues in the kidney"}]},{"@id":"https://cir.nii.ac.jp/crid/1050014016718730368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Therapeutic Strategies to Overcome Fibrotic Barriers to Nanomedicine in the Pancreatic Tumor Microenvironment"}]},{"@id":"https://cir.nii.ac.jp/crid/1050564288768511744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cancer-associated fibroblasts in gastrointestinal cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1050569159969033984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Physiology and pathology of T-cell aging"}]},{"@id":"https://cir.nii.ac.jp/crid/1050845764130326528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Vimentin Expression in Tumor Microenvironment Predicts Survival in Pancreatic Ductal Adenocarcinoma: Heterogeneity in Fibroblast Population."},{"@value":"Vimentin expression in tumor microenvironment predicts survival in pancreatic ductal adenocarcinoma: heterogeneity in the fibroblast population"}]},{"@id":"https://cir.nii.ac.jp/crid/1051975278388289280","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pancreatic stellate cells derived from human pancreatic cancer demonstrate aberrant SPARC-dependent ECM remodeling in 3D engineered fibrotic tissue of clinically relevant thickness"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002217790344448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tumor Microenvironment and Differential Responses to Therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004234294034944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Elucidating the link between collagen and pancreatic cancer: what’s next?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004234902376832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Low Stromal Area and High Stromal Microvessel Density Predict Poor Prognosis in Pancreatic Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235490117504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Stromal barriers to nanomedicine penetration in the pancreatic tumor microenvironment"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236985294080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Molecular Pathogenesis and Targeted Therapy of Pancreatic Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236985595136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Micro-RNA-130a-3p Regulates Gemcitabine Resistance via PPARG in Cholangiocarcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142434815232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Breaking the cycle: Targeting of NDRG1 to inhibit bi‐directional oncogenic cross‐talk between pancreatic cancer and stroma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142732068096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Regulation of heterogeneous cancer-associated fibroblasts: the molecular pathology of activated signaling pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142845899776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The “histological replacement growth pattern” represents aggressive invasive behavior in liver metastasis from pancreatic cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168882230400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"N-acetyl cysteine induces quiescent-like pancreatic stellate cells from an active state and attenuates cancer-stroma interactions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017282229400576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Good and Bad Stroma in Pancreatic Cancer: Relevance of Functional States of Cancer-Associated Fibroblasts"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017282241897600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Senescent Human Pancreatic Stellate Cells Secrete CXCR2 Agonist CXCLs to Promote Proliferation and Migration of Human Pancreatic Cancer AsPC-1 and MIAPaCa-2 Cell Lines"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021389821472512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Targeting ROCK2 improves macromolecular permeability in a 3D fibrotic pancreatic cancer microenvironment model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025430195369856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Plasticity and Tumor Microenvironment in Pancreatic Cancer: Genetic, Metabolic, and Immune Perspectives"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025431091449344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Isorhamnetin exerts anti-proliferative effect on cancer-associated fibroblasts by inducing cell cycle arrest"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690826294272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691145357184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691955248000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283694891312256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Extra-pancreatic invasion induces lipolytic and fibrotic changes in the adipose microenvironment, with released fatty acids enhancing the invasiveness of pancreatic cancer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283695646631040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Direct Interaction between Carcinoma Cells and Cancer Associated Fibroblasts for the Regulation of Cancer Invasion"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706223241088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708436645504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pancreatic tumor microenvironment confers highly malignant properties on pancreatic cancer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285709528629248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nrf2 promotes mutant K-ras/p53-driven pancreatic carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285712902942976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tamoxifen mechanically reprograms the tumor microenvironment via\n                    <scp>HIF</scp>\n                    ‐1A and reduces cancer cell survival"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617390993152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Phenotypic heterogeneity, stability and plasticity in tumor‐promoting carcinoma‐associated fibroblasts"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617474238336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Three Distinct Stroma Types in Human Pancreatic Cancer Identified by Image Analysis of Fibroblast Subpopulations and Collagen"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643749905792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643764772224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nrf2 expression in pancreatic stellate cells promotes progression of cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643824968320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"New high-throughput screening detects compounds that suppress pancreatic stellate cell activation and attenuate pancreatic cancer growth"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643861966208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Remodeling tumor microenvironment with nanomedicines"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298339725501952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeutics"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345522362368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Matrix remodeling‐associated protein 8 is a marker of a subset of cancer‐associated fibroblasts in pancreatic cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757191438336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Significance of Cancer-Associated Fibroblasts in the Interactions of Cancer Cells with the Tumor Microenvironment of Heterogeneous Tumor Tissue"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302864787360768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A comprehensive analysis of tumor-stromal collagen in relation to pathological, molecular, and immune characteristics and patient survival in pancreatic ductal adenocarcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865728219008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Revealing neuropilin expression patterns in pancreatic cancer: From single‑cell to therapeutic opportunities (Review)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165796651648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Kindlin-2 in pancreatic stellate cells promotes the progression of pancreatic cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166761871104","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166772398848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cancer-associated fibroblasts induce cancer cell apoptosis that regulates invasion mode of tumours"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181983544192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hypoxic stellate cells of pancreatic cancer stroma regulate extracellular matrix fiber organization and cancer cell motility"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567188224316032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Stromal remodeling by the BET bromodomain inhibitor JQ1 suppresses the progression of human pancreatic cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360568470444454656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cancer‐associated fibroblasts that restrain cancer progression: Hypotheses and perspectives"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092709248256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Functional diversity of cancer‐associated fibroblasts in modulating drug resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092881252224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118802005760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Histopathological atlas of desmoplastic reaction characterization in colorectal cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118804705536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"ERAP2 is a novel target involved in autophagy and activation of pancreatic stellate cells via UPR signaling pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118814076032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The effect of the low stromal ratio induced by neoadjuvant chemotherapy on recurrence patterns in borderline resectable pancreatic ductal adenocarcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118838788736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360579813385901952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade"}]},{"@id":"https://cir.nii.ac.jp/crid/1360579814676355584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360579819990704256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin/Islr in Cancer Fibrosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584340516648832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Incorporation of human iPSC-derived stromal cells creates a pancreatic cancer organoid with heterogeneous cancer-associated fibroblasts"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588380603019904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Targeting Cancer‐Associated Fibroblasts: Eliminate or Reprogram?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848655069360512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Adipose tissue‐derived stromal cells are sources of cancer‐associated fibroblasts and enhance tumor progression by dense collagen matrix"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656932108544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Exosomes derived from pancreatic cancer cells induce activation and profibrogenic activities in pancreatic stellate cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658385521920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mint3-mediated L1CAM expression in fibroblasts promotes cancer cell proliferation via integrin α5β1 and tumour growth"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658669275136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"ETS-Transcription Factor ETV1 Regulates Stromal Expansion and Metastasis in Pancreatic Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659482012416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"p53 functional deficiency in human colon cancer cells promotes fibroblast-mediated angiogenesis and tumor growth"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567610418560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"B lymphocytes contribute to stromal reaction in pancreatic ductal adenocarcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593719040768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861288381062144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Safety and efficacy of MIKE-1 in patients with advanced pancreatic cancer: a study protocol for an open-label phase I/II investigator-initiated clinical trial based on a drug repositioning approach that reprograms the tumour stroma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861704798336256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The heterogeneity of cancer‐associated fibroblast subpopulations: Their origins, biomarkers, and roles in the tumor microenvironment"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707145135872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Heterogeneity of Cancer-Associated Fibroblasts and the Tumor Immune Microenvironment in Pancreatic Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707151693184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Translational nanomedicine potentiates immunotherapy in sarcoma by normalizing the microenvironment"}]},{"@id":"https://cir.nii.ac.jp/crid/1361131421295595264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361412896283407616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Heat Shock Protein 47 Maintains Cancer Cell Growth by Inhibiting the Unfolded Protein Response Transducer IRE1α"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975844697111936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pancreatic carcinoma metastasis to a lung carcinoma lesion and pulmonary fibrotic regions, overtaking the stromal microenvironment"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975846228774272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dissecting the Stromal Signaling and Regulation of Myeloid Cells and Memory Effector T Cells in Pancreatic Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1390003825209453056","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The current situation and issues regarding pathological diagnosis of pancreatic ductal adenocarcinoma"},{"@language":"ja","@value":"膵管癌の病理学的診断の現状と課題"}]},{"@id":"https://cir.nii.ac.jp/crid/1390013784268255232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pancreatic cancer stromal heterogeneity characterized by multiplex immunohistochemistry-based image analyses"},{"@language":"ja","@value":"膵癌組織イメージングによる線維芽細胞サブタイプの同定，膵癌間質多様性の特徴化"}]},{"@id":"https://cir.nii.ac.jp/crid/1390290537431552256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Fibrotic elements within the tumor microenvironment and its implications for nano-drug delivery systems"},{"@language":"ja","@value":"がん微小環境における線維化とナノDDS"},{"@language":"ja-Kana","@value":"ガン ビショウ カンキョウ ニ オケル センイカ ト ナノ DDS"}]},{"@id":"https://cir.nii.ac.jp/crid/1390858209198434816","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Development of anti-cancer drug effect enhancers by transforming cancer-associated fibroblasts"},{"@language":"ja","@value":"癌関連線維芽細胞の形質改変による抗癌剤効果増強剤の開発"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.ccr.2014.04.021"},{"@type":"CROSSREF","@value":"10.1101/cshperspect.a026781_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1080/17474124.2018.1448268_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1111/cas.13630_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1245/s10434-015-4463-x_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1245/s10434-017-5871-x_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1016/j.ccell.2016.10.003_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1053/j.gastro.2016.06.005_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1097/mpa.0000000000000499_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1096/fj.202002279r_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1186/s13046-020-01611-0_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1002/cam4.2954_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1186/s13046-021-01939-1_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.3390/cancers14143315_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.3390/ijms23169275_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1016/j.jconrel.2024.03.041_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.3390/cancers16234094_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1016/j.biopha.2025.117954_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.3390/cancers7040876_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1007/s00441-016-2471-1_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1038/s41388-018-0144-0_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1093/carcin/bgx043_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.15252/embr.201846557_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1245/s10434-019-07891-x_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2017.10.141_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1111/febs.15851_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1158/1078-0432.ccr-20-2298_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1016/j.cell.2021.07.020_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1152/ajpgi.00120.2021_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1111/imr.12969_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1016/j.pan.2021.04.002_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1002/wnan.1730_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.2958/suizo.38.37_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1038/s41388-022-02288-9_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.3390/cancers15030724_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.3390/cancers15092536_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1007/s00535-023-02020-8_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.3892/ol.2024.14247_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1038/nm.4494_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1038/onc.2017.49_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.18632/oncotarget.11129_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.2958/suizo.35.242_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1016/j.canlet.2017.01.008_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1111/cas.14346_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1111/cas.14578_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1158/0008-5472.can-19-2745_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1093/jjco/hyab040_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1016/j.pan.2021.09.012_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1007/s10585-021-10142-7_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1016/j.ajpath.2021.05.019_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.26508/lsa.202101230_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1186/s13046-022-02301-9_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1111/pin.13198_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.3389/fcell.2021.749924_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1016/j.celrep.2023.113420_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1111/cas.16443_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1002/ijc.31775_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1038/oncsis.2017.27_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1093/carcin/bgw085_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.18632/oncotarget.15430_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1093/intimm/dxaa006_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1080/2162402x.2020.1794359_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.2745/dds.36.232_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1007/s13402-021-00614-z_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.2958/suizo.38.28_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1186/s12885-022-09272-2_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1111/cas.15609_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.3390/cancers14163994_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1016/j.jconrel.2022.12.016_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1016/j.biomaterials.2018.11.023_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1016/j.stem.2017.12.009_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1053/j.gastro.2017.01.010_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1158/0008-5472.can-19-0454_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1158/1541-7786.mcr-19-0673_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1097/md.0000000000015888_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1038/s41575-019-0115-0_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1158/1078-0432.ccr-18-4192_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1097/mpa.0000000000000744_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"},{"@type":"CROSSREF","@value":"10.1016/j.canlet.2016.01.016_references_DOI_3SAZ9HEJVFJB0zycR2a1LjmhYpL"}]}