{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319026168960.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1128/aac.01173-08"}},{"identifier":{"@type":"URI","@value":"https://journals.asm.org/doi/pdf/10.1128/AAC.01173-08"}},{"identifier":{"@type":"PMID","@value":"19124662"}}],"dc:title":[{"@value":"Contribution of\n            <i>vraSR</i>\n            and\n            <i>graSR</i>\n            Point Mutations to Vancomycin Resistance in Vancomycin-Intermediate\n            <i>Staphylococcus aureus</i>"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            We describe here the genetic analysis of a vancomycin-susceptible\n            <jats:italic>Staphylococcus aureus</jats:italic>\n            (VSSA) strain, Mu50Ω, a strain related to vancomycin-intermediate\n            <jats:italic>S. aureus</jats:italic>\n            (VISA) strain Mu50. Using a combination of Mu50Ω whole-genome sequencing and genome engineering, we observed a stepwise evolution of vancomycin resistance from VSSA to VISA after the mutated\n            <jats:italic>vraS</jats:italic>\n            and\n            <jats:italic>graR</jats:italic>\n            genes of Mu50 were engineered into Mu50Ω.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319026168962","@type":"Researcher","foaf:name":[{"@value":"Longzhu Cui"}],"jpcoar:affiliationName":[{"@value":"Department of Bacteriology"},{"@value":"Department of Infection Control Science, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319026168960","@type":"Researcher","foaf:name":[{"@value":"Hui-min Neoh"}],"jpcoar:affiliationName":[{"@value":"Department of Bacteriology"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319026168963","@type":"Researcher","foaf:name":[{"@value":"Mitsutaka Shoji"}],"jpcoar:affiliationName":[{"@value":"Department of Infection Control Science, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319026168961","@type":"Researcher","foaf:name":[{"@value":"Keiichi Hiramatsu"}],"jpcoar:affiliationName":[{"@value":"Department of Bacteriology"},{"@value":"Department of Infection Control Science, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00664804"},{"@type":"EISSN","@value":"10986596"}],"prism:publicationName":[{"@value":"Antimicrobial Agents and Chemotherapy"}],"dc:publisher":[{"@value":"American Society for Microbiology"}],"prism:publicationDate":"2009-03","prism:volume":"53","prism:number":"3","prism:startingPage":"1231","prism:endingPage":"1234"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://journals.asm.org/non-commercial-tdm-license"],"url":[{"@id":"https://journals.asm.org/doi/pdf/10.1128/AAC.01173-08"}],"createdAt":"2009-01-06","modifiedAt":"2022-02-21","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Staphylococcus%20aureus","dc:title":"Staphylococcus aureus"},{"@id":"https://cir.nii.ac.jp/all?q=Base%20Sequence","dc:title":"Base Sequence"},{"@id":"https://cir.nii.ac.jp/all?q=Sequence%20Homology,%20Amino%20Acid","dc:title":"Sequence Homology, Amino Acid"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Sequence%20Data","dc:title":"Molecular Sequence Data"},{"@id":"https://cir.nii.ac.jp/all?q=Vancomycin%20Resistance","dc:title":"Vancomycin Resistance"},{"@id":"https://cir.nii.ac.jp/all?q=Microbial%20Sensitivity%20Tests","dc:title":"Microbial Sensitivity Tests"},{"@id":"https://cir.nii.ac.jp/all?q=Sequence%20Analysis,%20DNA","dc:title":"Sequence Analysis, DNA"},{"@id":"https://cir.nii.ac.jp/all?q=Anti-Bacterial%20Agents","dc:title":"Anti-Bacterial Agents"},{"@id":"https://cir.nii.ac.jp/all?q=DNA-Binding%20Proteins","dc:title":"DNA-Binding Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Chromosome%20Walking","dc:title":"Chromosome Walking"},{"@id":"https://cir.nii.ac.jp/all?q=Bacterial%20Proteins","dc:title":"Bacterial Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Vancomycin","dc:title":"Vancomycin"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Point%20Mutation","dc:title":"Point Mutation"},{"@id":"https://cir.nii.ac.jp/all?q=Amino%20Acid%20Sequence","dc:title":"Amino Acid Sequence"},{"@id":"https://cir.nii.ac.jp/all?q=Genetic%20Engineering","dc:title":"Genetic Engineering"},{"@id":"https://cir.nii.ac.jp/all?q=Genome,%20Bacterial","dc:title":"Genome, Bacterial"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004236114476928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Activated ADI pathway: the initiator of intermediate vancomycin resistance in <i>Staphylococcus aureus</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617547915904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Association of mprF mutations with cross-resistance to daptomycin and vancomycin in methicillin-resistant Staphylococcus aureus (MRSA)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168407313024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Comprehensive Identification of Mutations Responsible for Heterogeneous 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