{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319106973184.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1182/blood-2005-02-0530"}},{"identifier":{"@type":"URI","@value":"http://ashpublications.org/blood/article-pdf/106/7/2551/1635071/zh801905002551.pdf"}},{"identifier":{"@type":"PMID","@value":"15956276"}}],"dc:title":[{"@value":"Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Innate immune responses to bacteria require cooperative interactions between host recognition molecules and phagocytes. The peptidoglycan recognition proteins (PGRPs) are a large group of proteins found in insects and mammals that bind to bacterial peptidoglycan (PGN). PGRP-S is located with other antimicrobial proteins, such as lysozyme, in the granules of human neutrophils. Whereas both PGRP-S and lysozyme recognize PGN, the exact binding specificity of human PGRP-S, its functional activity, and its potential synergy with other neutrophil-derived bactericidal proteins such as lysozyme have not been determined. Here we show that human PGRP-S binds to and inhibits the growth of Staphylococcus aureus (containing lysine-type PGN) and Escherichia coli (containing mesodiaminopimelic acid-type PGN). The binding affinity and thus antimicrobial activity of PGRP-S is determined by the third amino acid in the PGN stem peptide. Furthermore, the antimicrobial effect of PGRP-S against E coli is synergistic with lysozyme, and lysozyme and PGRP-S colocalize in neutrophil extracellular traps (NETs), suggesting that these granule-derived proteins act together to kill bacteria trapped in the NETs. Taken together, these results indicate that human PGRP-S plays a role in innate immunity in the context of neutrophils by contributing to the killing of intracellular and extracellular bacteria. (Blood. 2005;106:2551-2558)</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319106973185","@type":"Researcher","foaf:name":[{"@value":"Ju Hyun Cho"}],"jpcoar:affiliationName":[{"@value":"From the Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA; the Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan; and the Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319106973313","@type":"Researcher","foaf:name":[{"@value":"Iain P. Fraser"}],"jpcoar:affiliationName":[{"@value":"From the Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA; the Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan; and the Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319106973184","@type":"Researcher","foaf:name":[{"@value":"Koichi Fukase"}],"jpcoar:affiliationName":[{"@value":"From the Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA; the Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan; and the Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319106973314","@type":"Researcher","foaf:name":[{"@value":"Shoichi Kusumoto"}],"jpcoar:affiliationName":[{"@value":"From the Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA; the Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan; and the Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA."}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326204999040","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00362616"},{"@type":"NRID","@value":"1000000362616"},{"@type":"NRID","@value":"9000006764407"},{"@type":"NRID","@value":"9000383838834"},{"@type":"NRID","@value":"9000006709221"},{"@type":"NRID","@value":"9000256026958"},{"@type":"NRID","@value":"9000242565786"},{"@type":"NRID","@value":"9000396141388"},{"@type":"NRID","@value":"9000257738181"},{"@type":"NRID","@value":"9000404530380"},{"@type":"NRID","@value":"9000413773626"},{"@type":"NRID","@value":"9000404852024"},{"@type":"NRID","@value":"9000260215455"},{"@type":"NRID","@value":"9000258733671"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read_0118566"}],"foaf:name":[{"@value":"Yukari Fujimoto"}],"jpcoar:affiliationName":[{"@value":"From the Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA; the Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan; and the Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319106973315","@type":"Researcher","foaf:name":[{"@value":"Gregory L. Stahl"}],"jpcoar:affiliationName":[{"@value":"From the Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA; the Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan; and the Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319106973186","@type":"Researcher","foaf:name":[{"@value":"R. Alan B. Ezekowitz"}],"jpcoar:affiliationName":[{"@value":"From the Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA; the Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan; and the Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00064971"},{"@type":"EISSN","@value":"15280020"}],"prism:publicationName":[{"@value":"Blood"}],"dc:publisher":[{"@value":"American Society of Hematology"}],"prism:publicationDate":"2005-10-01","prism:volume":"106","prism:number":"7","prism:startingPage":"2551","prism:endingPage":"2558"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://ashpublications.org/blood/article-pdf/106/7/2551/1635071/zh801905002551.pdf"}],"createdAt":"2005-06-15","modifiedAt":"2021-07-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Staphylococcus%20aureus","dc:title":"Staphylococcus aureus"},{"@id":"https://cir.nii.ac.jp/all?q=Time%20Factors","dc:title":"Time Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Neutrophils","dc:title":"Neutrophils"},{"@id":"https://cir.nii.ac.jp/all?q=Peptidoglycan","dc:title":"Peptidoglycan"},{"@id":"https://cir.nii.ac.jp/all?q=Immunity,%20Innate","dc:title":"Immunity, Innate"},{"@id":"https://cir.nii.ac.jp/all?q=Recombinant%20Proteins","dc:title":"Recombinant Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Kinetics","dc:title":"Kinetics"},{"@id":"https://cir.nii.ac.jp/all?q=Anti-Infective%20Agents","dc:title":"Anti-Infective Agents"},{"@id":"https://cir.nii.ac.jp/all?q=Microscopy,%20Fluorescence","dc:title":"Microscopy, Fluorescence"},{"@id":"https://cir.nii.ac.jp/all?q=Escherichia%20coli","dc:title":"Escherichia coli"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Biotinylation","dc:title":"Biotinylation"},{"@id":"https://cir.nii.ac.jp/all?q=Muramidase","dc:title":"Muramidase"},{"@id":"https://cir.nii.ac.jp/all?q=Carrier%20Proteins","dc:title":"Carrier Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Binding","dc:title":"Protein Binding"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050564288162643328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Role of 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