{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319175369984.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/bjc.2011.23"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/bjc201123.pdf"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/bjc201123"}},{"identifier":{"@type":"PMID","@value":"21304530"}}],"dc:title":[{"@value":"The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer"}],"description":[{"notation":[{"@value":"On the base of the microRNA (miRNA) expression signature of bladder cancer (BC), we found that miR-1 and miR-133a were significantly downregulated in BC. In this study, we focussed on the functional significance of miR-1 and miR-133a in BC cell lines and identified a molecular network of these miRNAs.We investigated the miRNA expression signature of BC clinical specimens and identified several downregulated miRNAs (miR-133a, miR-204, miR-1, miR-139-5p, and miR-370). MiR-1 and miR-133a showed potential role of tumour suppressors by functional analyses of BC cells such as cell proliferation, apoptosis, migration, and invasion assays. Molecular target searches of these miRNAs showed that transgelin 2 (TAGLN2) was directly regulated by both miR-1 and miR-133a. Silencing of TAGLN2 study demonstrated significant inhibitions of cell proliferation and increase of apoptosis in BC cell lines. The immunohistochemistry showed a positive correlation between TAGLN2 expression and tumour grade in clinical BC specimens.The downregulation of miR-1 and miR-133a was a frequent event in BC, and these miRNAs were recognised as tumour suppressive. TAGLN2 may be a target of both miRNAs and had a potential oncogenic function. Therefore, novel molecular networks provided by miRNAs may provide new insights into the underlying molecular mechanisms of BC."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004055515299973","@type":"Researcher","foaf:name":[{"@value":"H Yoshino"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319175369856","@type":"Researcher","foaf:name":[{"@value":"T Chiyomaru"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319175369985","@type":"Researcher","foaf:name":[{"@value":"H Enokida"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319175369987","@type":"Researcher","foaf:name":[{"@value":"K Kawakami"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319175369989","@type":"Researcher","foaf:name":[{"@value":"S Tatarano"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319175369986","@type":"Researcher","foaf:name":[{"@value":"K Nishiyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319175369988","@type":"Researcher","foaf:name":[{"@value":"N Nohata"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319175369990","@type":"Researcher","foaf:name":[{"@value":"N Seki"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319175369984","@type":"Researcher","foaf:name":[{"@value":"M Nakagawa"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00070920"},{"@type":"EISSN","@value":"15321827"}],"prism:publicationName":[{"@value":"British Journal of Cancer"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2011-02-08","prism:volume":"104","prism:number":"5","prism:startingPage":"808","prism:endingPage":"818"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://www.springer.com/tdm"],"url":[{"@id":"http://www.nature.com/articles/bjc201123.pdf"},{"@id":"http://www.nature.com/articles/bjc201123"}],"createdAt":"2011-02-08","modifiedAt":"2023-05-18","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Microfilament%20Proteins","dc:title":"Microfilament Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Down-Regulation","dc:title":"Down-Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Muscle%20Proteins","dc:title":"Muscle Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Apoptosis","dc:title":"Apoptosis"},{"@id":"https://cir.nii.ac.jp/all?q=Transfection","dc:title":"Transfection"},{"@id":"https://cir.nii.ac.jp/all?q=MicroRNAs","dc:title":"MicroRNAs"},{"@id":"https://cir.nii.ac.jp/all?q=Urinary%20Bladder%20Neoplasms","dc:title":"Urinary Bladder Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Movement","dc:title":"Cell Movement"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line,%20Tumor","dc:title":"Cell Line, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Diagnostics","dc:title":"Molecular Diagnostics"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Proliferation","dc:title":"Cell Proliferation"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001202613112960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Aberrant expression 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hypomethylation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298336542108160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Targeting of the glutamine transporter SLC1A5 induces cellular senescence in clear cell renal cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181288844800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Involvement of aberrantly expressed microRNAs in the pathogenesis of head and neck squamous cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185442399360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i><scp>ZFP</scp>36L2</i> promotes cancer cell aggressiveness and is regulated by antitumor <i>micro<scp>RNA</scp>‐375</i> in pancreatic ductal 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