{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319208142080.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/0006-8993(94)90784-6"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:0006899394907846?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:0006899394907846?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"7882040"}}],"dc:title":[{"@value":"Histamine depletion in brain caused by treatment with (S) α-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons"}],"description":[{"notation":[{"@value":"The effect of (S)alpha-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region of the hippocampus 7 days after 3 min ischemia was enhanced by treatment with FMH. These results indicate that depletion of brain histamine aggravates neuronal death of hippocampal CA2 neurons after 3 min ischemia."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319208142083","@type":"Researcher","foaf:name":[{"@value":"Koreaki Sugimoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319208142087","@type":"Researcher","foaf:name":[{"@value":"Koji Abe"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319208142082","@type":"Researcher","foaf:name":[{"@value":"Tsong-Hai Lee"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319208142081","@type":"Researcher","foaf:name":[{"@value":"Eiko Sakurai"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319208142080","@type":"Researcher","foaf:name":[{"@value":"Kazuhiko Yanai"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319208142084","@type":"Researcher","foaf:name":[{"@value":"Kyuya Kogure"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319208142085","@type":"Researcher","foaf:name":[{"@value":"Yasuto Itoyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319208142086","@type":"Researcher","foaf:name":[{"@value":"Takehiko Watanabe"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00068993"}],"prism:publicationName":[{"@value":"Brain Research"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"1994-12","prism:volume":"666","prism:number":"2","prism:startingPage":"279","prism:endingPage":"283"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:0006899394907846?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:0006899394907846?httpAccept=text/plain"}],"createdAt":"2003-04-24","modifiedAt":"2025-11-02","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Neurons","dc:title":"Neurons"},{"@id":"https://cir.nii.ac.jp/all?q=Histamine%20Antagonists","dc:title":"Histamine Antagonists"},{"@id":"https://cir.nii.ac.jp/all?q=Brain","dc:title":"Brain"},{"@id":"https://cir.nii.ac.jp/all?q=Methylhistidines","dc:title":"Methylhistidines"},{"@id":"https://cir.nii.ac.jp/all?q=Hippocampus","dc:title":"Hippocampus"},{"@id":"https://cir.nii.ac.jp/all?q=Brain%20Ischemia","dc:title":"Brain Ischemia"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Gerbillinae","dc:title":"Gerbillinae"},{"@id":"https://cir.nii.ac.jp/all?q=Histamine","dc:title":"Histamine"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001204272611200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Towards Understanding Mechanisms of Drug Action and Functions of the Body on the Molecular Level. Studies on histamine with L-histidine decarboxylase, a histamine-forming enzyme, as a probe: from purification to gene knockout."},{"@language":"ja","@value":"薬の作用機序と生体機能の分子的理解に向けて　　ヒスタミンに関する研究　　ヒスチジン脱炭酸酵素の精製から欠損マウスまで"},{"@value":"ヒスタミンに関する研究:ヒスチジン脱炭酸酵素の精製から欠損マウスまで"},{"@language":"ja-Kana","@value":"ヒスタミン ニ カンスル ケンキュウ ヒスチジン ダツタンサン コウソ ノ セイセイ カラ ケッソン マウス マデ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679247221120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cerebral ischemia and histamine."},{"@language":"ja","@value":"脳虚血とヒスタミン"},{"@language":"ja-Kana","@value":"ノウキョケツ ト ヒスタミン"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/0006-8993(94)90784-6"},{"@type":"OPENAIRE","@value":"doi_dedup___::a7a6bd5320598b5c199f8a9e656d2d2e"},{"@type":"CROSSREF","@value":"10.1254/fpj.118.159_references_DOI_V8VPh4DG3ofHch24Qw2im9W34hM"},{"@type":"CROSSREF","@value":"10.1254/fpj.120.215_references_DOI_V8VPh4DG3ofHch24Qw2im9W34hM"}]}