{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319219099008.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1161/01.cir.98.9.839"}},{"identifier":{"@type":"URI","@value":"https://www.ahajournals.org/doi/full/10.1161/01.CIR.98.9.839"}}],"dc:title":[{"@value":"Inflammation, Pravastatin, and the Risk of Coronary Events After Myocardial Infarction in Patients With Average Cholesterol Levels"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            <jats:italic>Background</jats:italic>\n            —We studied whether inflammation after myocardial infarction (MI) is a risk factor for recurrent coronary events and whether randomized treatment with pravastatin reduces that risk.\n          </jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results</jats:italic>\n            —A nested case-control design was used to compare C-reactive protein (CRP) and serum amyloid A (SAA) levels in prerandomization blood samples from 391 participants in the Cholesterol and Recurrent Events (CARE) trial who subsequently developed recurrent nonfatal MI or a fatal coronary event (cases) and from an equal number of age- and sex-matched participants who remained free of these events during follow-up (control subjects). Overall, CRP and SAA were higher among cases than control subjects (for CRP\n            <jats:italic>P</jats:italic>\n            =0.05; for SAA\n            <jats:italic>P</jats:italic>\n            =0.006) such that those with levels in the highest quintile had a relative risk (RR) of recurrent events 75% higher than those with levels in the lowest quintile (for CRP RR=1.77,\n            <jats:italic>P</jats:italic>\n            =0.02; for SAA RR=1.74,\n            <jats:italic>P</jats:italic>\n            =0.02). The study group with the highest risk was that with consistent evidence of inflammation (elevation of both CRP and SAA) who were randomly assigned to placebo (RR=2.81,\n            <jats:italic>P</jats:italic>\n            =0.007); this risk estimate was greater than the product of the individual risks associated with inflammation or placebo assignment alone. In stratified analyses, the association between inflammation and risk was significant among those randomized to placebo (RR=2.11,\n            <jats:italic>P</jats:italic>\n            =0.048) but was attenuated and nonsignificant among those randomized to pravastatin (RR=1.29,\n            <jats:italic>P</jats:italic>\n            =0.5).\n          </jats:p>\n          <jats:p>\n            <jats:italic>Conclusions</jats:italic>\n            —Evidence of inflammation after MI is associated with increased risk of recurrent coronary events. Therapy with pravastatin may decrease this risk, an observation consistent with a nonlipid effect of this agent.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319219099008","@type":"Researcher","foaf:name":[{"@value":"Paul M. Ridker"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass (P.M.R., M.A.P., F.M.S., E.B.); the Children’s Hospital Medical Center, Boston (N.R.); the University of Texas School of Public Health, Houston (L.A.M.); the Veterans Administration Medical Center, Tucson, Ariz (S.G.); and the University of Missouri, Columbia (G.C.F.)."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319219098881","@type":"Researcher","foaf:name":[{"@value":"Nader Rifai"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass (P.M.R., M.A.P., F.M.S., E.B.); the Children’s Hospital Medical Center, Boston (N.R.); the University of Texas School of Public Health, Houston (L.A.M.); the Veterans Administration Medical Center, Tucson, Ariz (S.G.); and the University of Missouri, Columbia (G.C.F.)."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319219099011","@type":"Researcher","foaf:name":[{"@value":"Marc A. Pfeffer"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass (P.M.R., M.A.P., F.M.S., E.B.); the Children’s Hospital Medical Center, Boston (N.R.); the University of Texas School of Public Health, Houston (L.A.M.); the Veterans Administration Medical Center, Tucson, Ariz (S.G.); and the University of Missouri, Columbia (G.C.F.)."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319219099010","@type":"Researcher","foaf:name":[{"@value":"Frank M. Sacks"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass (P.M.R., M.A.P., F.M.S., E.B.); the Children’s Hospital Medical Center, Boston (N.R.); the University of Texas School of Public Health, Houston (L.A.M.); the Veterans Administration Medical Center, Tucson, Ariz (S.G.); and the University of Missouri, Columbia (G.C.F.)."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319219099013","@type":"Researcher","foaf:name":[{"@value":"Lemuel A. Moye"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass (P.M.R., M.A.P., F.M.S., E.B.); the Children’s Hospital Medical Center, Boston (N.R.); the University of Texas School of Public Health, Houston (L.A.M.); the Veterans Administration Medical Center, Tucson, Ariz (S.G.); and the University of Missouri, Columbia (G.C.F.)."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319219098880","@type":"Researcher","foaf:name":[{"@value":"Steven Goldman"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass (P.M.R., M.A.P., F.M.S., E.B.); the Children’s Hospital Medical Center, Boston (N.R.); the University of Texas School of Public Health, Houston (L.A.M.); the Veterans Administration Medical Center, Tucson, Ariz (S.G.); and the University of Missouri, Columbia (G.C.F.)."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319219099009","@type":"Researcher","foaf:name":[{"@value":"Greg C. Flaker"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass (P.M.R., M.A.P., F.M.S., E.B.); the Children’s Hospital Medical Center, Boston (N.R.); the University of Texas School of Public Health, Houston (L.A.M.); the Veterans Administration Medical Center, Tucson, Ariz (S.G.); and the University of Missouri, Columbia (G.C.F.)."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319219099012","@type":"Researcher","foaf:name":[{"@value":"Eugene Braunwald"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass (P.M.R., M.A.P., F.M.S., E.B.); the Children’s Hospital Medical Center, Boston (N.R.); the University of Texas School of Public Health, Houston (L.A.M.); the Veterans Administration Medical Center, Tucson, Ariz (S.G.); and the University of Missouri, Columbia (G.C.F.)."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00097322"},{"@type":"EISSN","@value":"15244539"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00097322"}],"prism:publicationName":[{"@value":"Circulation"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"1998-09","prism:volume":"98","prism:number":"9","prism:startingPage":"839","prism:endingPage":"844"},"reviewed":"false","url":[{"@id":"https://www.ahajournals.org/doi/full/10.1161/01.CIR.98.9.839"}],"createdAt":"2012-06-12","modifiedAt":"2025-02-06","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004232029902080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tumor specific low pH environments enhance the cytotoxicity of lovastatin and cantharidin"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345427048192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Combined impact of residual inflammatory risk and chronic kidney disease on long-term clinical outcomes in patients undergoing percutaneous coronary intervention"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306905633232512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Noninvasive Assessment of Vascular Function"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846645918122368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The impact of in-stent neoatherosclerosis on long-term clinical outcomes: an observational study from the Kobe University Hospital optical coherence tomography registry"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204431387264","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pravastatin Improves Insulin Resistance in Dyslipidemic Patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204432192128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cholesterol-independent Effects of Statins and New Therapeutic Targets: Ischemic Stroke and Dementia"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204432219648","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of Pitavastatin on Lipid Profiles and High-Sensitivity CRP in Japanese Subjects with Hypercholesterolemia: Kansai Investigation of Statin for Hyperlipidemic Intervention in Metabolism and Endocrinology (KISHIMEN) Investigatars"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204432832768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Statin therapy reduces inflammatory markers in hypercholesterolemic patients with high baseline levels"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204432876032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Global Analysis of RNA Expression Profile in Human Vascular Cells Treated with Statins"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204870917376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of Statin on the 5 Years Clinical Outcomes in Dialysis Patients Treated with Sirolimus-eluting 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Surrogate Biomarkers : Clinical Significance and Limitation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679408007936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"HMG-CoA Reductase Inhibitors Suppress the Development and Progression of Carotid Artery Intimal-medial Thickening in Hypercholesterolemic Type 2 Diabetic Patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679408069760","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of Statin on Restenosis after Radius Stent Implantation in Patients with Acute Coronary Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679409282048","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"An Update on the Role of Markers of Inflammation in Atherosclerosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679409960192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Potential Role of Statins in Inflammation and Atherosclerosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680081802240","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Upstream Therapy for Atrial Fibrillation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680084554624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Preprocedural High-Sensitivity C-Reactive Protein Predicts Long-Term Outcome of Percutaneous Coronary Intervention"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680084897408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Inflammatory Mechanisms of Cardiovascular Remodeling"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681315756288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Relationship between Pulse Wave Velocity and Serum Inflammatory Markers among Healthy Adults in a Community"},{"@language":"ja","@value":"健康な地域住民における脈波速度と炎症マーカーの関連性について"},{"@language":"ja-Kana","@value":"ケンコウ ナ チイキ ジュウミン ニ オケル ミャクハ ソクド ト エンショウ マーカー ノ カンレンセイ ニ ツイテ"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1161/01.cir.98.9.839"},{"@type":"CROSSREF","@value":"10.1536/ihj.52.280_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.5551/jat.10.140_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.5551/jat.11.253_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.1016/j.jjcc.2021.10.023_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.5551/jat.2600_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.1253/circj.71.a75_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.3999/jscpt.38.295_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.5551/jat.12.322_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.5551/jat.12.149_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.1016/j.jacasi.2024.09.015_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.4244/eijy15m12_05_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.5551/jat.12.302_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.2974/kmj.56.201_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-16-0790_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-18-0063_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.1253/circj.70.1269_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.1016/j.canlet.2010.05.010_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.5551/jat.e581_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.5551/jat.11.62_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine.53.1122_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"},{"@type":"CROSSREF","@value":"10.5551/jat.3632_references_DOI_SFlri2mybaUPr8YK5iNbD0bCgMQ"}]}