{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319237893376.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1053/j.ajkd.2006.05.024"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0272638606009954?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0272638606009954?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"16931225"}}],"dc:title":[{"@value":"A Case of “Pure” Preeclampsia With Nephrotic Syndrome Before 15 Weeks of Gestation in a Patient Whose Renal Biopsy Showed Glomerular Capillary Endotheliosis"}],"description":[{"notation":[{"@value":"A 35-year-old Japanese woman for whom a previous health checkup showed normal blood pressure and urinalysis results without serological abnormalities developed nephrotic syndrome with severe hypertension at 15 gestational weeks. The renal biopsy performed at 17 weeks of gestation showed severe glomerular capillary endotheliosis. By means of electron microscopy, no electron-dense deposits were observed in glomeruli, and foot-process arrangement was normal. Histological findings indicated the patient's glomerular damage was caused by the mechanisms of preeclampsia. The patient underwent an elective abortion at 18 weeks of gestation. Clinical abnormalities vanished completely within 3 months after the elective abortion, which provided additional evidence that proteinuria and hypertension were caused purely by pregnancy. In general, the term preeclampsia refers to new onset of hypertension and proteinuria after 20 weeks of gestation. When proteinuria or hypertension is newly observed before 20 weeks of gestation, they are practically associated with triploidy, trophoblastic disease, or antiphospholipid syndrome. However, our case was not associated with them. Therefore, we called this case \"pure\" preeclampsia. We confirm the notion for the first time that preeclampsia associated with glomerular capillary endotheliosis can occur before 20 weeks of gestation. In addition, this report describes the earliest onset of preeclampsia compared with previously published reports. We also discuss causes of preeclampsia in early gestation and refer to the issue of the application of renal biopsies during pregnancy."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319237893380","@type":"Researcher","foaf:name":[{"@value":"Toshiyuki Imasawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319237893378","@type":"Researcher","foaf:name":[{"@value":"Tetsuji Nishiwaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319237893379","@type":"Researcher","foaf:name":[{"@value":"Motonobu Nishimura"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319237893383","@type":"Researcher","foaf:name":[{"@value":"Nobuaki Shikama"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319237893384","@type":"Researcher","foaf:name":[{"@value":"Ryutaro Matsumura"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319237893381","@type":"Researcher","foaf:name":[{"@value":"Masaaki Nagai"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319237893377","@type":"Researcher","foaf:name":[{"@value":"Akiko Soyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319237893385","@type":"Researcher","foaf:name":[{"@value":"Kentaro Koike"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319237893376","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Kitamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319237893382","@type":"Researcher","foaf:name":[{"@value":"Kensuke Joh"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02726386"}],"prism:publicationName":[{"@value":"American Journal of Kidney Diseases"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2006-09","prism:volume":"48","prism:number":"3","prism:startingPage":"495","prism:endingPage":"501"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0272638606009954?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0272638606009954?httpAccept=text/plain"}],"createdAt":"2006-08-22","modifiedAt":"2025-10-03","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Nephrotic%20Syndrome","dc:title":"Nephrotic Syndrome"},{"@id":"https://cir.nii.ac.jp/all?q=Biopsy","dc:title":"Biopsy"},{"@id":"https://cir.nii.ac.jp/all?q=Kidney%20Glomerulus","dc:title":"Kidney Glomerulus"},{"@id":"https://cir.nii.ac.jp/all?q=Endothelial%20Cells","dc:title":"Endothelial Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Abortion,%20Induced","dc:title":"Abortion, Induced"},{"@id":"https://cir.nii.ac.jp/all?q=Pre-Eclampsia","dc:title":"Pre-Eclampsia"},{"@id":"https://cir.nii.ac.jp/all?q=Pregnancy","dc:title":"Pregnancy"},{"@id":"https://cir.nii.ac.jp/all?q=Pregnancy%20Trimester,%20Second","dc:title":"Pregnancy Trimester, Second"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Kidney%20Diseases","dc:title":"Kidney Diseases"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050010293300142464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A case of hypertensive disorders of pregnancy that developed at 9 weeks of gestation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857596491416192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nephrotic syndrome due to preeclampsia before 20 weeks of gestation: a case report"}]},{"@id":"https://cir.nii.ac.jp/crid/1390016880924367104","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pure preeclampsia at 16 weeks of gestation with an increasing trend of sFlt-1/PlGF ratio: A case report and literature review"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1053/j.ajkd.2006.05.024"},{"@type":"OPENAIRE","@value":"doi_dedup___::cf1f821427bd47c17b3e7cc07f94dff6"},{"@type":"CROSSREF","@value":"10.1007/s13730-021-00592-z_references_DOI_SKIVxDJZ7HV4c5Fs1o9W9LUKxft"},{"@type":"CROSSREF","@value":"10.1186/s12882-020-01876-9_references_DOI_SKIVxDJZ7HV4c5Fs1o9W9LUKxft"},{"@type":"CROSSREF","@value":"10.14390/jsshp.hrp2023-004_references_DOI_SKIVxDJZ7HV4c5Fs1o9W9LUKxft"}]}