{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319253000064.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/dta.1535"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fdta.1535"}},{"identifier":{"@type":"URI","@value":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdf/10.1002/dta.1535"}}],"dc:title":[{"@value":"Analysis of AM‐2201 and metabolites in a drugs and driving case"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>This case report describes the analysis of AM‐2201 in plant material and its metabolites in human urine obtained from an operator of a motor vehicle in the United States. The samples were taken from the driver because of his illegal driving activities and, his subsequent erratic behaviour. The AM‐2201 was extracted from a sample of plant material by sonicating it in methanol, after which an aliquot was taken and diluted with aqueous phosphate buffer (pH 6) and extracted by solid‐phase extraction using a C8/aminopropyl SPE cartridge. The cartridges were washed, dried, and eluted with ethyl acetate‐ methanol solvent system. The urine sample was hydrolyzed with β‐glucuronidase at pH 6.8 before being diluted with aqueous phosphate buffer (pH 6) and extracted with the same type of SPE cartridge. After evaporation of the eluates, the samples were dissolved in mobile phase for analysis by liquid chromatography‐tandem mass spectrometry (LC‐MS/MS). Analysis of the plant material determined the concentration to be 0.05% (AM2201) by mass of dry material. The concentration of AM‐2201 (AM2201‐N‐(4‐hydroxypentyl ) metabolite in the urine was found to be 3.1 ng/ml. The urine also contained 109 ng/ml of delta‐9‐tetrahydrocannabinol carboxylic acid but no other drugs including JWH‐018 metabolites. Copyright © 2013 John Wiley & Sons, Ltd.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319253000065","@type":"Researcher","foaf:name":[{"@value":"Albert A. Elian"}],"jpcoar:affiliationName":[{"@value":"Massachusetts State Police Crime Laboratory  59 Horsepond Road Sudbury MA 01776 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319253000064","@type":"Researcher","foaf:name":[{"@value":"Jeffery Hackett"}],"jpcoar:affiliationName":[{"@value":"UCT Inc.  2731 Bartram Road Bristol PA 19007 USA"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"19427603"},{"@type":"EISSN","@value":"19427611"}],"prism:publicationName":[{"@value":"Drug Testing and Analysis"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2013-10-28","prism:volume":"6","prism:number":"4","prism:startingPage":"389","prism:endingPage":"395"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fdta.1535"},{"@id":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdf/10.1002/dta.1535"}],"createdAt":"2013-10-29","modifiedAt":"2025-10-14","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390282680222971264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"薬物検査に適した迅速・簡便な血液および唾液の採取法の検討<br/>—摂取薬物未変化体の検出を指向して—"},{"@language":"en","@value":"Examination of rapid and simple sampling methods of blood and saliva for drug testing<br/>—To detect drugs in unchanged forms—"},{"@value":"薬物検査に適した迅速・簡便な血液および唾液の採取法の検討 : 摂取薬物未変化体の検出を指向して"},{"@language":"ja-Kana","@value":"ヤクブツ ケンサ ニ テキシタ ジンソク ・ カンベン ナ ケツエキ オヨビ ダエキ ノ サイシュホウ ノ ケントウ : セッシュ ヤクブツ ミヘンカタイ ノ ケンシュツ オ シコウ シテ"},{"@value":"Examination of rapid and simple sampling methods of blood and saliva for drug testing<br/>&mdash;To detect drugs in unchanged forms&mdash;"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/dta.1535"},{"@type":"CROSSREF","@value":"10.3408/jafst.688_references_DOI_KFnfiAHRVCNCbhYypoCMbxnk0XS"}]}