{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319294241920.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/adma.201806774"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fadma.201806774"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/adma.201806774"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/adma.201806774"}},{"identifier":{"@type":"URI","@value":"https://advanced.onlinelibrary.wiley.com/doi/am-pdf/10.1002/adma.201806774"}},{"identifier":{"@type":"URI","@value":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/adma.201806774"}}],"dc:title":[{"@value":"Modular Metal–Organic Polyhedra Superassembly: From Molecular‐Level Design to Targeted Drug Delivery"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Targeted drug delivery remains at the forefront of biomedical research but remains a challenge to date. Herein, the first superassembly of nanosized metal–organic polyhedra (MOP) and their biomimetic coatings of lipid bilayers are described to synergistically combine the advantages of micelles and supramolecular coordination cages for targeted drug delivery. The superassembly technique affords unique hydrophobic features that endow individual MOP to act as nanobuilding blocks and enable their superassembly into larger and well‐defined nanocarriers with homogeneous sizes over a broad range of diameters. Various cargos are controllably loaded into the MOP with high payloads, and the nanocages are then superassembled to form multidrug delivery systems. Additionally, functional nanoparticles are introduced into the superassemblies via a one‐pot process for versatile bioapplications. The MOP superassemblies are surface‐engineered with epidermal growth factor receptors and can be targeted to cancer cells. In vivo studies indicated the assemblies to have a substantial circulation half‐life of 5.6 h and to undergo renal clearance—characteristics needed for nanomedicines.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319294241925","@type":"Researcher","foaf:name":[{"@value":"Wei Zhu"}],"jpcoar:affiliationName":[{"@value":"Center for Micro‐Engineered Materials Department of Chemical and Biological Engineering The University of New Mexico  Albuquerque NM 87131 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319294241930","@type":"Researcher","foaf:name":[{"@value":"Jimin Guo"}],"jpcoar:affiliationName":[{"@value":"Center for Micro‐Engineered Materials Department of Chemical and Biological Engineering The University of New Mexico  Albuquerque NM 87131 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319294241929","@type":"Researcher","foaf:name":[{"@value":"Yi Ju"}],"jpcoar:affiliationName":[{"@value":"ARC Centre of Excellence in Convergent Bio–Nano Science and Technology and The Department of Chemical Engineering The University of Melbourne  Parkville Victoria 3010 Australia"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319294241920","@type":"Researcher","foaf:name":[{"@value":"Rita E. Serda"}],"jpcoar:affiliationName":[{"@value":"Department of Internal Medicine Molecular Medicine The University of New Mexico  Albuquerque NM 87131 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319294241926","@type":"Researcher","foaf:name":[{"@value":"Jonas G. Croissant"}],"jpcoar:affiliationName":[{"@value":"Center for Micro‐Engineered Materials Department of Chemical and Biological Engineering The University of New Mexico  Albuquerque NM 87131 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319294241923","@type":"Researcher","foaf:name":[{"@value":"Jin Shang"}],"jpcoar:affiliationName":[{"@value":"School of Energy and Environment City University of Hong Kong  Tat Chee Avenue Kowloon Hong Kong SAR P. R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319294241927","@type":"Researcher","foaf:name":[{"@value":"Eric Coker"}],"jpcoar:affiliationName":[{"@value":"Sandia National Laboratories Applied Optical/Plasma Sciences  P.O. Box 5800, MS 1411 Albuquerque NM 87185‐1411 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319294241922","@type":"Researcher","foaf:name":[{"@value":"Jacob Ongudi Agola"}],"jpcoar:affiliationName":[{"@value":"Center for Micro‐Engineered Materials Department of Chemical and Biological Engineering The University of New Mexico  Albuquerque NM 87131 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319294241928","@type":"Researcher","foaf:name":[{"@value":"Qi‐Zhi Zhong"}],"jpcoar:affiliationName":[{"@value":"ARC Centre of Excellence in Convergent Bio–Nano Science and Technology and The Department of Chemical Engineering The University of Melbourne  Parkville Victoria 3010 Australia"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319294242048","@type":"Researcher","foaf:name":[{"@value":"Yuan Ping"}],"jpcoar:affiliationName":[{"@value":"College of Pharmaceutical Sciences Zhejiang University  Hangzhou 310058 P. R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319294241921","@type":"Researcher","foaf:name":[{"@value":"Frank Caruso"}],"jpcoar:affiliationName":[{"@value":"ARC Centre of Excellence in Convergent Bio–Nano Science and Technology and The Department of Chemical Engineering The University of Melbourne  Parkville Victoria 3010 Australia"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319294241924","@type":"Researcher","foaf:name":[{"@value":"C. Jeffrey Brinker"}],"jpcoar:affiliationName":[{"@value":"Center for Micro‐Engineered Materials Department of Chemical and Biological Engineering The University of New Mexico  Albuquerque NM 87131 USA"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09359648"},{"@type":"EISSN","@value":"15214095"}],"prism:publicationName":[{"@value":"Advanced Materials"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2019-01-31","prism:volume":"31","prism:number":"12","prism:startingPage":"1806774"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#am","http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fadma.201806774"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/adma.201806774"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/adma.201806774"},{"@id":"https://advanced.onlinelibrary.wiley.com/doi/am-pdf/10.1002/adma.201806774"},{"@id":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/adma.201806774"}],"createdAt":"2019-01-31","modifiedAt":"2025-10-06","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360290617863524224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Crystalline assembly of metal–organic polyhedra driven by ionic interactions with polyoxometalates"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298755642171008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Creation of single molecular conjugates of metal–organic cages and DNA"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584340519101440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Water-Soluble Ionic Metal–Organic Polyhedra as a Versatile Platform for Enzyme Bio-immobilization"}]},{"@id":"https://cir.nii.ac.jp/crid/2050588892102334592","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Metal-organic cages (MOCs) : from discrete to cage-based extended architectures"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/adma.201806774"},{"@type":"CROSSREF","@value":"10.1246/cl.190731_references_DOI_XZNQS5ySd8x8mTsFyWOUnpHYHDG"},{"@type":"CROSSREF","@value":"10.1039/d1cc01185e_references_DOI_XZNQS5ySd8x8mTsFyWOUnpHYHDG"},{"@type":"CROSSREF","@value":"10.1039/d3cc00460k_references_DOI_XZNQS5ySd8x8mTsFyWOUnpHYHDG"},{"@type":"CROSSREF","@value":"10.1021/jacs.2c13798_references_DOI_XZNQS5ySd8x8mTsFyWOUnpHYHDG"}]}