{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319320132864.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1074/jbc.m506771200"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021925820593423?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021925820593423?httpAccept=text/plain"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1074/jbc.M506771200"}},{"identifier":{"@type":"PMID","@value":"16129676"}},{"identifier":{"@type":"NAID","@value":"80017514818"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Recruitment of Tumor Necrosis Factor Receptor-associated Factor Family Proteins to Apoptosis Signal-regulating Kinase 1 Signalosome Is Essential for Oxidative Stress-induced Cell Death"}],"description":[{"notation":[{"@value":"Apoptosis signal-regulating kinase 1 (ASK1) plays a pivotal role in oxidative stress-induced cell death. Reactive oxygen species disrupt the interaction of ASK1 with its cellular inhibitor thioredoxin and thereby activates ASK1. However, the precise mechanism by which ASK1 freed from thioredoxin undergoes oligomerization-dependent activation has not been fully elucidated. Here we show that endogenous ASK1 constitutively forms a high molecular mass complex including Trx ( approximately 1,500-2,000 kDa), which we designate ASK1 signalosome. Upon H(2)O(2) treatment, the ASK1 signalosome forms a higher molecular mass complex at least in part because of the recruitment of tumor necrosis factor receptor-associated factor 2 (TRAF2) and TRAF6. Consistent with our previous findings that TRAF2 and TRAF6 activate ASK1, H(2)O(2)-induced ASK1 activation and cell death were strongly reduced in the cells derived from Traf2-/- and Traf6-/- mice. A novel signaling complex including TRAF2, TRAF6, and ASK1 may thus be the key component in oxidative stress-induced cell death."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319320132870","@type":"Researcher","foaf:name":[{"@value":"Takuya Noguchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319320132869","@type":"Researcher","foaf:name":[{"@value":"Kohsuke Takeda"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319320132871","@type":"Researcher","foaf:name":[{"@value":"Atsushi Matsuzawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319320132864","@type":"Researcher","foaf:name":[{"@value":"Kaoru Saegusa"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319320132867","@type":"Researcher","foaf:name":[{"@value":"Hiroyasu Nakano"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319320132866","@type":"Researcher","foaf:name":[{"@value":"Jin Gohda"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319320132865","@type":"Researcher","foaf:name":[{"@value":"Jun-ichiro Inoue"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801181441792","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00242206"},{"@type":"NRID","@value":"1000000242206"},{"@type":"NRID","@value":"9000003765989"},{"@type":"NRID","@value":"9000411808081"},{"@type":"NRID","@value":"9000008006440"},{"@type":"NRID","@value":"9000413854759"},{"@type":"NRID","@value":"9000412376061"},{"@type":"NRID","@value":"9000000332673"},{"@type":"NRID","@value":"9000409867635"},{"@type":"NRID","@value":"9000253184026"},{"@type":"NRID","@value":"9000309170219"},{"@type":"NRID","@value":"9000411980438"},{"@type":"NRID","@value":"9000252813379"},{"@type":"NRID","@value":"9000241868895"},{"@type":"NRID","@value":"9000020242310"},{"@type":"NRID","@value":"9000399261612"},{"@type":"NRID","@value":"9000411774311"},{"@type":"NRID","@value":"9000369347734"},{"@type":"NRID","@value":"9000018761284"},{"@type":"NRID","@value":"9000413854774"},{"@type":"NRID","@value":"9000253181391"},{"@type":"NRID","@value":"9000010925664"},{"@type":"NRID","@value":"9000367417968"},{"@type":"NRID","@value":"9000255679475"},{"@type":"NRID","@value":"9000413854769"},{"@type":"NRID","@value":"9000252815552"},{"@type":"NRID","@value":"9000018368184"},{"@type":"NRID","@value":"9000321629874"},{"@type":"NRID","@value":"9000411812807"},{"@type":"NRID","@value":"9000405644490"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0053993"}],"foaf:name":[{"@value":"Hidenori Ichijo"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00219258"}],"prism:publicationName":[{"@value":"Journal of Biological Chemistry"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2005-11","prism:volume":"280","prism:number":"44","prism:startingPage":"37033","prism:endingPage":"37040"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0021925820593423?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0021925820593423?httpAccept=text/plain"},{"@id":"https://syndication.highwire.org/content/doi/10.1074/jbc.M506771200"}],"createdAt":"2005-08-29","modifiedAt":"2021-07-16","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=TNF%20Receptor-Associated%20Factor%206","dc:title":"TNF Receptor-Associated Factor 6"},{"@id":"https://cir.nii.ac.jp/all?q=Macrophages","dc:title":"Macrophages"},{"@id":"https://cir.nii.ac.jp/all?q=Intracellular%20Signaling%20Peptides%20and%20Proteins","dc:title":"Intracellular Signaling Peptides and Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Membrane%20Proteins","dc:title":"Membrane Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Apoptosis","dc:title":"Apoptosis"},{"@id":"https://cir.nii.ac.jp/all?q=Fibroblasts","dc:title":"Fibroblasts"},{"@id":"https://cir.nii.ac.jp/all?q=Kidney","dc:title":"Kidney"},{"@id":"https://cir.nii.ac.jp/all?q=TNF%20Receptor-Associated%20Factor%202","dc:title":"TNF Receptor-Associated Factor 2"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Oxidative%20Stress","dc:title":"Oxidative Stress"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Immunoprecipitation","dc:title":"Immunoprecipitation"},{"@id":"https://cir.nii.ac.jp/all?q=Cells,%20Cultured","dc:title":"Cells, Cultured"},{"@id":"https://cir.nii.ac.jp/all?q=Spleen","dc:title":"Spleen"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781775837696","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"14086204"},{"@type":"JGN","@value":"JP14086204"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14086204/"}],"notation":[{"@language":"ja","@value":"ASK1の活性化機構の解明と機能解析"},{"@language":"en","@value":"Elucidation of the activation mechanisms and functions of ASK1"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001335830000384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction"}]},{"@id":"https://cir.nii.ac.jp/crid/1050282677453154048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Immune Control by TRAF6-Mediated Pathways of Epithelial Cells in the EIME (Epithelial Immune Microenvironment)"}]},{"@id":"https://cir.nii.ac.jp/crid/1050282814083858304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The ASK family kinases differentially mediate type I interferon induction and apoptosis during the antiviral response"},{"@value":"The ASK family kinases 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oxidative stress-induced cell death by ubiquitination-dependent degradation of TAK1"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943666535680","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"Pathological investigation of oxidative stress in the post‐genomic era"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204272970112","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ストレスと生活　　４　　ＡＳＫファミリーによるストレス応答～細胞がストレスを感じる仕組みと疾患～"},{"@language":"en","@value":"ASK family proteins in stress and disease"},{"@value":"ASKファミリーによるストレス応答--細胞がストレスを感じる仕組みと疾患"},{"@language":"ja-Kana","@value":"ASK ファミリー ニ ヨル ストレス オウトウ サイボウ ガ ストレス オ カンジル シクミ ト シッカン"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205212648832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"ASK1 Signalosome: a Signaling Complex Essential for Cellular Stress Responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679175904000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"哺乳類細胞のストレス受容・伝達機構とそれに起因する疾患"},{"@language":"en","@value":"Mechanism of Stress Sensing and Signaling in Mammalian Cells and Its Roles in Human Diseases"},{"@language":"ja-Kana","@value":"ホニュウルイ サイボウ ノ ストレス ジュヨウ デンタツ キコウ ト ソレニ キイン スル シッカン"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679649599872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Thioredoxin binding protein (TBP)-2/Txnip and α-arrestin proteins in cancer and diabetes mellitus"},{"@value":"Thioredoxin binding protein (TBP)-2/Txnip and alpha-arrestin proteins in cancer and diabetes mellitus"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680188909056","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"ROS-dependent Activation of ASK1 in Inflammatory Signaling"},{"@value":"ROS-dependent Activation of ASKI in Inflammatory Signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1390283659867944704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pro-apoptotic functions of TRAF2 in p53-mediated apoptosis induced by cisplatin"}]},{"@id":"https://cir.nii.ac.jp/crid/1390564227317330816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Reactive Oxygen Species (ROS) Signaling: Regulatory Mechanisms and Pathophysiological Roles"},{"@language":"ja","@value":"活性酸素シグナルの制御機構及びその破綻に伴う疾患発症機序の解明"},{"@value":"Review for award 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