FACTOR XIII (FIBRIN STABILISING FACTOR) IN HENOCH‐SCHÖNLEIN'S PURPURA

PER HENRIKSSON, ULLA HEDNER, INGA MARIE NILSSON

doi:10.1111/j.1651-2227.1977.tb07893.x

FACTOR XIII (FIBRIN STABILISING FACTOR) IN HENOCH‐SCHÖNLEIN'S PURPURA

DOI Web Site Web Site 被引用文献11件

書誌事項

公開日: 1977-05

権利情報

http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1111/j.1651-2227.1977.tb07893.x

公開者: Wiley

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説明

<jats:p><jats:bold>Abstract.</jats:bold>In 13 out of 17 consecutive children with Henoch‐Schönlein's purpura the factor XIII determined with the dansyl cadaverine method was found to be decreased during the acute phase. The decrease is assumed to be due to a specific degradation by proteolytic enzymes liberated from inflammatory cells, with defective local haemostasis as a result. This assumption is strengthened by the observation that treatment with factor XIII combined with an antifibrinolytic drug controlled life‐threatening gastro‐intestinal bleeding in one of the patients. It would therefore appear that such treatment might offer a new possibility of controlling severe haemorrhages in Henoch‐Schönlein's purpura.</jats:p>