{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319443281920.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1161/circulationaha.119.044795"}},{"identifier":{"@type":"URI","@value":"https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.119.044795"}}],"dc:title":[{"@value":"Prevalence of Familial Hypercholesterolemia Among the General Population and Patients With Atherosclerotic Cardiovascular Disease"}],"dcterms:alternative":[{"@value":"A Systematic Review and Meta-Analysis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec>\n            <jats:title>Background:</jats:title>\n            <jats:p>Contemporary studies suggest that familial hypercholesterolemia (FH) is more frequent than previously reported and increasingly recognized as affecting individuals of all ethnicities and across many regions of the world. Precise estimation of its global prevalence and prevalence across World Health Organization regions is needed to inform policies aiming at early detection and atherosclerotic cardiovascular disease (ASCVD) prevention. The present study aims to provide a comprehensive assessment and more reliable estimation of the prevalence of FH than hitherto possible in the general population (GP) and among patients with ASCVD.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Methods:</jats:title>\n            <jats:p>We performed a systematic review and meta-analysis including studies reporting on the prevalence of heterozygous FH in the GP or among those with ASCVD. Studies reporting gene founder effects and focused on homozygous FH were excluded. The search was conducted through Medline, Embase, Cochrane, and Global Health, without time or language restrictions. A random-effects model was applied to estimate the overall pooled prevalence of FH in the general and ASCVD populations separately and by World Health Organization regions.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Results:</jats:title>\n            <jats:p>\n              From 3225 articles, 42 studies from the GP and 20 from populations with ASCVD were eligible, reporting on 7 297 363 individuals/24 636 cases of FH and 48 158 patients/2827 cases of FH, respectively. More than 60% of the studies were from Europe. Use of the Dutch Lipid Clinic Network criteria was the commonest diagnostic method. Within the GP, the overall pooled prevalence of FH was 1:311 (95% CI, 1:250–1:397; similar between children [1:364] and adults [1:303],\n              <jats:italic>P</jats:italic>\n              =0.60; across World Health Organization regions where data were available,\n              <jats:italic>P</jats:italic>\n              =0.29; and between population-based and electronic health records–based studies,\n              <jats:italic>P</jats:italic>\n              =0.82). Studies with ≤10 000 participants reported a higher prevalence (1:200–289) compared with larger cohorts (1:365–407;\n              <jats:italic>P</jats:italic>\n              <0.001). The pooled prevalence among those with ASCVD was 18-fold higher than in the GP (1:17 [95% CI, 1:12–1:24]), driven mainly by coronary artery disease (1:16; [95% CI, 1:12–1:23]). Between-study heterogeneity was large (\n              <jats:italic>I</jats:italic>\n              <jats:sup>2</jats:sup>\n              >95%). Tests assessing bias were nonsignificant (\n              <jats:italic>P</jats:italic>\n              >0.3).\n            </jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:</jats:title>\n            <jats:p>With an overall prevalence of 1:311, FH is among the commonest genetic disorders in the GP, similarly present across different regions of the world, and is more frequent among those with ASCVD. The present results support the advocacy for the institution of public health policies, including screening programs, to identify FH early and to prevent its global burden.</jats:p>\n          </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319443281927","@type":"Researcher","foaf:name":[{"@value":"Pengwei Hu"}],"jpcoar:affiliationName":[{"@value":"Imperial Center for Cardiovascular Disease Prevention (P.H., K.I.D., C.A.T.S., K.K.R., A.J.V.-V.), Imperial College London, UK."},{"@value":"Department of Primary Care and Public Health (P.H., K.I.D., C.A.T.S., K.K.R., A.J.V.-V., M.T.A.S.), Imperial College London, UK."},{"@value":"Department of Health Service, Logistics University of People’s Armed Police Force, Tianjin, China (P.H.)."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319443281926","@type":"Researcher","foaf:name":[{"@value":"Kanika I. Dharmayat"}],"jpcoar:affiliationName":[{"@value":"Imperial Center for Cardiovascular Disease Prevention (P.H., K.I.D., C.A.T.S., K.K.R., A.J.V.-V.), Imperial College London, UK."},{"@value":"Department of Primary Care and Public Health (P.H., K.I.D., C.A.T.S., K.K.R., A.J.V.-V., M.T.A.S.), Imperial College London, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319443281923","@type":"Researcher","foaf:name":[{"@value":"Christophe A.T. Stevens"}],"jpcoar:affiliationName":[{"@value":"Imperial Center for Cardiovascular Disease Prevention (P.H., K.I.D., C.A.T.S., K.K.R., A.J.V.-V.), Imperial College London, UK."},{"@value":"Department of Primary Care and Public Health (P.H., K.I.D., C.A.T.S., K.K.R., A.J.V.-V., M.T.A.S.), Imperial College London, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319443281921","@type":"Researcher","foaf:name":[{"@value":"Mansour T.A. Sharabiani"}],"jpcoar:affiliationName":[{"@value":"Department of Primary Care and Public Health (P.H., K.I.D., C.A.T.S., K.K.R., A.J.V.-V., M.T.A.S.), Imperial College London, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319443282048","@type":"Researcher","foaf:name":[{"@value":"Rebecca S. Jones"}],"jpcoar:affiliationName":[{"@value":"School of Public Health, and Charing Cross Campus Library (R.S.J.), Imperial College London, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319443281924","@type":"Researcher","foaf:name":[{"@value":"Gerald F. Watts"}],"jpcoar:affiliationName":[{"@value":"School of Medicine, Faculty of Health and Medical Sciences, University of Western Australia, Perth (G.F.W.)."},{"@value":"Lipid Disorders Clinic, Department of Cardiology, Royal Perth Hospital, Australia (G.F.W.)."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319443281920","@type":"Researcher","foaf:name":[{"@value":"Jacques Genest"}],"jpcoar:affiliationName":[{"@value":"McGill University Health Center, Montreal, QC, Canada (J.G.)."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319443281922","@type":"Researcher","foaf:name":[{"@value":"Kausik K. Ray"}],"jpcoar:affiliationName":[{"@value":"Imperial Center for Cardiovascular Disease Prevention (P.H., K.I.D., C.A.T.S., K.K.R., A.J.V.-V.), Imperial College London, UK."},{"@value":"Department of Primary Care and Public Health (P.H., K.I.D., C.A.T.S., K.K.R., A.J.V.-V., M.T.A.S.), Imperial College London, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319443281925","@type":"Researcher","foaf:name":[{"@value":"Antonio J. Vallejo-Vaz"}],"jpcoar:affiliationName":[{"@value":"Imperial Center for Cardiovascular Disease Prevention (P.H., K.I.D., C.A.T.S., K.K.R., A.J.V.-V.), Imperial College London, UK."},{"@value":"Department of Primary Care and Public Health (P.H., K.I.D., C.A.T.S., K.K.R., A.J.V.-V., M.T.A.S.), Imperial College London, UK."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00097322"},{"@type":"EISSN","@value":"15244539"}],"prism:publicationName":[{"@value":"Circulation"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2020-06-02","prism:volume":"141","prism:number":"22","prism:startingPage":"1742","prism:endingPage":"1759"},"reviewed":"false","url":[{"@id":"https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.119.044795"}],"createdAt":"2020-05-29","modifiedAt":"2025-02-06","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050307966327859584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"JCS/JCC/JSPCCS 2024 Guideline on Genetic Testing and Counseling in Cardiovascular Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168742874752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Genetic mutations, regression of Achilles tendon thickness, and cardiovascular events among patients with familial hypercholesterolemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016976769811328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impact of Healthy Lifestyle in Patients With Familial Hypercholesterolemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017282186374528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impact of variants of uncertain significance of LDL receptor on phenotypes of familial hypercholesterolemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643814503168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Human genetics and its impact on cardiovascular disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298754838053504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease in the Asia-Pacific Region"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865723749632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Coronary artery calcium among patients with heterozygous familial hypercholesterolaemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306504330332544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impact of changes in Achilles tendon thickening on cardiovascular events in patients with familial hypercholesterolemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306905607948928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Association of BMI, lipid-lowering medication, and age with prevalence of type 2 diabetes in adults with heterozygous familial hypercholesterolaemia: a worldwide cross-sectional study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580230580662528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Early diagnosis and treatments in childhood are associated with better prognosis in patients with familial hypercholesterolemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861401704394624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effects of Different Types of Pathogenic Variants on Phenotypes of Familial Hypercholesterolemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707133945856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synergistic effect of lipoprotein (a) and C-reactive protein on prognosis of familial hypercholesterolemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360862720287213696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Clinical Characteristics of Homozygous Familial Hypercholesterolemia in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1390006662423582592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"How Can We Improve the Diagnosis Rate of Familial Hypercholesterolemia by Amending Diagnosis Criteria?"},{"@value":"Clinical Diagnostic Criteria of Familial Hypercholesterolemia : A Comparison of the Japan Atherosclerosis Society and Dutch Lipid Clinic Network Criteria"}]},{"@id":"https://cir.nii.ac.jp/crid/1390007072282352768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Homozygous Familial Hypercholesterolemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1390010776355074688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Measurement of Achilles Tendon Thickness is a Key for International Harmonization in Clinical Diagnosis of Familial Hypercholesterolemia"},{"@value":"Achilles Tendon Thickness Assessed by X-ray Predicting a Pathogenic Mutation in Familial Hypercholesterolemia Gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1390292251338517504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Prospective Registry Study of Primary Dyslipidemia (PROLIPID): Rationale and Study Design"}]},{"@id":"https://cir.nii.ac.jp/crid/1390292936928839424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Advancements in the Treatment of Homozygous Familial Hypercholesterolemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1390295956279790464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Guidelines for the Diagnosis and Treatment of Pediatric Familial Hypercholesterolemia 2022"}]},{"@id":"https://cir.nii.ac.jp/crid/1390304969088169856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Utility of Discrepancies Between Friedewald and Martin Equations in Predicting Pathogenic Variants of Familial Hypercholesterolemia in Children"}]},{"@id":"https://cir.nii.ac.jp/crid/1390305721537319168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Assessments of Atherosclerosis and Treatment Strategies for Heterozygous Familial Hypercholesterolemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1390576745204518784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of Omega-3 Fatty Acid Supplementation on the Postprandial Metabolism of Apolipoprotein(a) in Familial Hypercholesterolemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1390577685334491392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Is High-Density Lipoprotein Functionality Useful as a Residual Risk Marker for Familial Hypercholesterolemia?"}]},{"@id":"https://cir.nii.ac.jp/crid/1390583790035503744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"JCS/JCC/JSPCCS 2024 Guideline on Genetic Testing and Counseling in Cardiovascular Disease"},{"@value":"Japanese College of Cardiology, Japanese Society of Pediatric Cardiology and Cardiac Surgery Joint Working Group. JCS/JCC/JSPCCS 2024 guideline on genetic testing and counseling in cardiovascular disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1390858906233204608","@type":"Article","resourceType":"letter","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Guidelines for the Diagnosis and Treatment of Adult Familial Hypercholesterolemia 2022"}]},{"@id":"https://cir.nii.ac.jp/crid/1390859160311192064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Impact of High-Density Lipoprotein Function, Rather Than High-Density Lipoprotein Cholesterol Level, on Cardiovascular Disease Among Patients With Familial Hypercholesterolemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1390863329503320320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022"},{"@value":"Japan Atherosclerosis Society(JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Disease 2022"}]},{"@id":"https://cir.nii.ac.jp/crid/1390863629154345984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Improved Efficiency of the Clinical Diagnostic Criteria for Familial Hypercholesterolemia in Children: A Comparison of the Japan Atherosclerosis Society Guidelines of 2017 and 2022"}]},{"@id":"https://cir.nii.ac.jp/crid/1390866345576854144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Assessment of Low-density Lipoprotein Cholesterol Levels and Non-invasive Vascular Health in School-aged Children: A Study in Ogasa District, Shizuoka Prefecture"}]},{"@id":"https://cir.nii.ac.jp/crid/1390870064891843456","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical Impact of Familial Hypercholesterolemia on Lower Extremity Artery Disease in Premature Patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1390870385390078336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Genetic Testing for Children with Familial Hypercholesterolemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1391130851444203776","@type":"Article","resourceType":"エディトリアル(editorial)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Targeted Panel Sequencing will Boost Detection of Genetic Backgrounds of Familial Hypercholesterolemia in the World's Most Populous Country"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1161/circulationaha.119.044795"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-20-0901_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.5551/jat.62869_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.1016/j.atherosclerosis.2021.11.031_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.5551/jat.rv17065_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.1016/j.jacl.2022.09.007_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.3400/avd.oa.25-00141_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.5551/jat.rv17050_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.1016/j.jjcc.2021.09.005_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.5551/jat.cr005_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.5551/jat.cr006_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.1016/j.jacasi.2021.08.008_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.5551/jat.gl2022_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.5551/jat.64795_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.1093/ehjopen/oead046_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.1016/j.jacasi.2023.07.011_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.1016/j.ajpc.2024.100660_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.1016/s2213-8587(24)00221-3_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.5551/jat.63222_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.5551/jat.63587_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.1016/j.ajpc.2022.100434_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.1016/j.jacasi.2022.10.012_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.5551/jat.64513_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-23-0926_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-24-0928_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-22-0829_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-22-0560_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.3389/fgene.2022.872056_references_DOI_JKwP6OQjNGIxFVBUuiFM60PlrLS"},{"@type":"CROSSREF","@value":"10.1016/j.ajpc.2022.100428_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.5551/jat.rv22041_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.1016/j.jjcc.2024.10.002_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.5551/jat.rv22046_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"},{"@type":"CROSSREF","@value":"10.5551/jat.ed139_references_DOI_WinouJE3lh9IvKMv8MVUV0titi9"}]}