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New blood and lymphatic vessels form through processes called angiogenesis and lymphangiogenesis, respectively. Angiogenesis is regulated by both activator and inhibitor molecules. More than a dozen different proteins have been identified as angiogenic activators and inhibitors. Levels of expression of angiogenic factors reflect the aggressiveness of tumor cells. The discovery of angiogenic inhibitors should help to reduce both morbidity and mortality from carcinomas. Thousands of patients have received antiangiogenic therapy to date. Despite their theoretical efficacy, antiangiogeic treatments have not proved beneficial in terms of long-term survival. There is an urgent need for a new comprehensive treatment strategy combining antiangiogenic agents with conventional cytoreductive treatments in the control of cancer."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319447808002","@type":"Researcher","foaf:name":[{"@value":"Naoyo Nishida"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319447808003","@type":"Researcher","foaf:name":[{"@value":"Hirohisa Yano"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319447808004","@type":"Researcher","foaf:name":[{"@value":"Takashi Nishida"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319447808001","@type":"Researcher","foaf:name":[{"@value":"Toshiharu Kamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319447808000","@type":"Researcher","foaf:name":[{"@value":"Masamichi Kojiro"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"11766344"}],"prism:publicationName":[{"@value":"Vascular Health and Risk Management"}],"dc:publisher":[{"@value":"Informa UK 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