{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319527367040.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/chem.201201195"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchem.201201195"}},{"identifier":{"@type":"URI","@value":"https://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/chem.201201195"}}],"dc:title":[{"@value":"Addressing Challenges in Palladium‐Catalyzed Cross‐Coupling Reactions Through Ligand Design"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The development of palladium‐catalyzed cross‐coupling reactions has revolutionized the synthesis of organic molecules on both bench‐top and industrial scales. While significant research effort has been directed toward evaluating how modifying various reaction parameters can influence the outcome of a given cross‐coupling reaction, the design and implementation of novel ancillary ligand frameworks has played a particularly important role in advancing the state‐of‐the‐art. This Review seeks to highlight notable examples from the recent chemical literature, in which newly developed ancillary ligands have enabled more challenging substrate transformations to be addressed with greater selectivity and/or under increasingly mild conditions. Throughout, the importance and subtlety of ligand effects in palladium‐catalyzed cross‐coupling reactions are described, in an effort to inspire further development and understanding within the field of ancillary ligand design.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319527367040","@type":"Researcher","foaf:name":[{"@value":"Rylan J. Lundgren"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319527367041","@type":"Researcher","foaf:name":[{"@value":"Mark Stradiotto"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09476539"},{"@type":"EISSN","@value":"15213765"}],"prism:publicationName":[{"@value":"Chemistry – A European Journal"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2012-07-11","prism:volume":"18","prism:number":"32","prism:startingPage":"9758","prism:endingPage":"9769"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchem.201201195"},{"@id":"https://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/chem.201201195"}],"createdAt":"2012-07-11","modifiedAt":"2025-10-12","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050306506451325056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Polystyrene-Supported PPh(3)in Monolithic Porous Material : Effect of Cross-Linking Degree on Coordination Mode and Catalytic Activity in Pd-Catalyzed C-C Cross-Coupling of Aryl Chlorides"},{"@value":"Polystyrene‐Supported PPh<sub>3</sub> in Monolithic Porous Material: Effect of Cross‐Linking Degree on Coordination Mode and Catalytic Activity in Pd‐Catalyzed C−C Cross‐Coupling of Aryl Chlorides"},{"@value":"Polystyrene-Supported PPh3 in Monolithic Porous Material: Effect of Cross-Linking Degree on Coordination Mode and Catalytic Activity in Pd-Catalyzed C−C Cross-Coupling of Aryl Chlorides"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002214424340480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Threefold Cross‐Linked Polystyrene–Triphenylphosphane Hybrids: Mono‐P‐Ligating Behavior and Catalytic Applications for Aryl Chloride Cross‐Coupling and C(sp<sup>3</sup>)H Borylation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092428870144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Trialkylphosphines Having a Bulky Phosphacyclopentane Backbone: Structural and Redox Properties Depending on the Exocyclic Alkyl Groups and EPR Observation of a Persistent Trialkylphosphine Radical Cation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658060890240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Deuterodechlorination of Aryl/Heteroaryl Chlorides Catalyzed by a Palladium/Unsymmetrical NHC System"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658160154112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Palladium-Catalyzed Synthesis of Heterocycle-Containing Diarylmethanes through Suzuki–Miyaura Cross-Coupling"}]},{"@id":"https://cir.nii.ac.jp/crid/1390291767548308480","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Multi-Point Solid-Supported Phosphines for Highly Active Heterogeneous Transition-Metal Catalysts"},{"@language":"ja","@value":"固相多点担持ホスフィンによる高活性不均一系遷移金属触媒の開発"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/chem.201201195"},{"@type":"CROSSREF","@value":"10.1002/anie.201306769_references_DOI_4z6r7OzneOErcZb3kUUhqUo7Yqq"},{"@type":"CROSSREF","@value":"10.1002/cctc.202000651_references_DOI_4z6r7OzneOErcZb3kUUhqUo7Yqq"},{"@type":"CROSSREF","@value":"10.1021/acs.joc.0c01393_references_DOI_4z6r7OzneOErcZb3kUUhqUo7Yqq"},{"@type":"CROSSREF","@value":"10.5059/yukigoseikyokaishi.80.198_references_DOI_4z6r7OzneOErcZb3kUUhqUo7Yqq"},{"@type":"CROSSREF","@value":"10.1021/jo5009178_references_DOI_4z6r7OzneOErcZb3kUUhqUo7Yqq"},{"@type":"CROSSREF","@value":"10.1021/acs.joc.6b01609_references_DOI_4z6r7OzneOErcZb3kUUhqUo7Yqq"}]}