{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319552605952.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/ni945"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/ni945.pdf"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/ni945"}},{"identifier":{"@type":"PMID","@value":"12830145"}},{"identifier":{"@type":"NAID","@value":"80016047817"}}],"dc:title":[{"@value":"An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid"}],"description":[{"notation":[{"@value":"Nucleotide-binding oligomerization domain protein 1 (NOD1) belongs to a family that includes multiple members with NOD and leucine-rich repeats in vertebrates and plants. NOD1 has been suggested to have a role in innate immune responses, but the mechanism involved remains unknown. Here we report that NOD1 mediates the recognition of peptidoglycan derived primarily from Gram-negative bacteria. Biochemical and functional analyses using highly purified and synthetic compounds indicate that the core structure recognized by NOD1 is a dipeptide, gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP). Murine macrophages deficient in NOD1 did not secrete cytokines in response to synthetic iE-DAP and did not prime the lipopolysaccharide response. Thus, NOD1 mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319552605953","@type":"Researcher","foaf:name":[{"@value":"Mathias Chamaillard"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319552606086","@type":"Researcher","foaf:name":[{"@value":"Masahito Hashimoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658483085953","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30282164"},{"@type":"NRID","@value":"1000030282164"},{"@type":"NRID","@value":"9000010518315"},{"@type":"NRID","@value":"9000006833879"},{"@type":"NRID","@value":"9000294357768"},{"@type":"NRID","@value":"9000024334009"},{"@type":"NRID","@value":"9000238863717"},{"@type":"NRID","@value":"9000020337550"},{"@type":"NRID","@value":"9000256341642"},{"@type":"NRID","@value":"9000018198934"},{"@type":"NRID","@value":"9000009985069"},{"@type":"NRID","@value":"9000020255752"},{"@type":"NRID","@value":"9000253436180"},{"@type":"NRID","@value":"9000402799120"},{"@type":"NRID","@value":"9000006198519"},{"@type":"NRID","@value":"9000021317436"},{"@type":"NRID","@value":"9000020256935"},{"@type":"NRID","@value":"9000008154158"},{"@type":"NRID","@value":"9000008198649"},{"@type":"NRID","@value":"9000020320635"},{"@type":"NRID","@value":"9000020336294"},{"@type":"NRID","@value":"9000016965971"},{"@type":"NRID","@value":"9000020120207"},{"@type":"NRID","@value":"9000020296797"},{"@type":"NRID","@value":"9000003166462"},{"@type":"NRID","@value":"9000010593005"},{"@type":"NRID","@value":"9000018519820"},{"@type":"NRID","@value":"9000255798609"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0198039"}],"foaf:name":[{"@value":"Yasuo Horie"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801206047488","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20334914"},{"@type":"NRID","@value":"1000020334914"},{"@type":"NRID","@value":"9000329010024"},{"@type":"NRID","@value":"9000411811736"},{"@type":"NRID","@value":"9000018238529"},{"@type":"NRID","@value":"9000412631382"},{"@type":"NRID","@value":"9000411807674"},{"@type":"NRID","@value":"9000411802082"},{"@type":"NRID","@value":"9000412637888"},{"@type":"NRID","@value":"9000018827664"},{"@type":"NRID","@value":"9000412604118"},{"@type":"NRID","@value":"9000411817404"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0116185"}],"foaf:name":[{"@value":"Junya Masumoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319552605958","@type":"Researcher","foaf:name":[{"@value":"Su Qiu"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319552606085","@type":"Researcher","foaf:name":[{"@value":"Lisa Saab"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276175986560","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60304557"},{"@type":"NRID","@value":"1000060304557"},{"@type":"NRID","@value":"9000022183592"},{"@type":"NRID","@value":"9000004663884"},{"@type":"NRID","@value":"9000347146300"},{"@type":"NRID","@value":"9000397698177"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0156592"}],"foaf:name":[{"@value":"Yasunori Ogura"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319552605952","@type":"Researcher","foaf:name":[{"@value":"Akiko Kawasaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326235681152","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80192722"},{"@type":"NRID","@value":"1000080192722"},{"@type":"NRID","@value":"9000021782546"},{"@type":"NRID","@value":"9000253073817"},{"@type":"NRID","@value":"9000256026962"},{"@type":"NRID","@value":"9000256020200"},{"@type":"NRID","@value":"9000256018585"},{"@type":"NRID","@value":"9000242565785"},{"@type":"NRID","@value":"9000311788303"},{"@type":"NRID","@value":"9000406221776"},{"@type":"NRID","@value":"9000256016071"},{"@type":"NRID","@value":"9000002162633"},{"@type":"NRID","@value":"9000021878200"},{"@type":"NRID","@value":"9000404852052"},{"@type":"NRID","@value":"9000256008892"},{"@type":"NRID","@value":"9000257738182"},{"@type":"NRID","@value":"9000021805970"},{"@type":"NRID","@value":"9000256022462"},{"@type":"NRID","@value":"9000257728237"},{"@type":"NRID","@value":"9000409009219"},{"@type":"NRID","@value":"9000404530379"},{"@type":"NRID","@value":"9000256011452"},{"@type":"NRID","@value":"9000006764310"},{"@type":"NRID","@value":"9000020727089"},{"@type":"NRID","@value":"9000021765560"},{"@type":"NRID","@value":"9000411532888"},{"@type":"NRID","@value":"9000283394357"},{"@type":"NRID","@value":"9000019241104"},{"@type":"NRID","@value":"9000403403446"},{"@type":"NRID","@value":"9000255696961"},{"@type":"NRID","@value":"9000002144424"},{"@type":"NRID","@value":"9000406018103"},{"@type":"NRID","@value":"9000001472029"},{"@type":"NRID","@value":"9000021867722"},{"@type":"NRID","@value":"9000353371892"},{"@type":"NRID","@value":"9000397864514"},{"@type":"NRID","@value":"9000403403449"},{"@type":"NRID","@value":"9000256020827"},{"@type":"NRID","@value":"9000260215456"},{"@type":"NRID","@value":"9000021870098"},{"@type":"NRID","@value":"9000410485966"},{"@type":"NRID","@value":"9000258733676"},{"@type":"NRID","@value":"9000408488503"},{"@type":"NRID","@value":"9000256016156"},{"@type":"NRID","@value":"9000256020612"},{"@type":"NRID","@value":"9000257723667"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0076573"}],"foaf:name":[{"@value":"Koichi Fukase"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658329027715","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30028253"},{"@type":"NRID","@value":"1000030028253"},{"@type":"NRID","@value":"9000020354502"},{"@type":"NRID","@value":"9000383082958"},{"@type":"NRID","@value":"9000253176129"},{"@type":"NRID","@value":"9000392757014"},{"@type":"NRID","@value":"9000255704080"},{"@type":"NRID","@value":"9000020133670"},{"@type":"NRID","@value":"9000253012651"},{"@type":"NRID","@value":"9000253103094"},{"@type":"NRID","@value":"9000253103864"},{"@type":"NRID","@value":"9000256020201"},{"@type":"NRID","@value":"9000256018587"},{"@type":"NRID","@value":"9000007997364"},{"@type":"NRID","@value":"9000008588511"},{"@type":"NRID","@value":"9000020408624"},{"@type":"NRID","@value":"9000021804562"},{"@type":"NRID","@value":"9000317133025"},{"@type":"NRID","@value":"9000253104288"},{"@type":"NRID","@value":"9000256372559"},{"@type":"NRID","@value":"9000014797826"},{"@type":"NRID","@value":"9000005268673"},{"@type":"NRID","@value":"9000018340563"},{"@type":"NRID","@value":"9000020087821"},{"@type":"NRID","@value":"9000021900869"},{"@type":"NRID","@value":"9000017936758"},{"@type":"NRID","@value":"9000274377381"},{"@type":"NRID","@value":"9000256011455"},{"@type":"NRID","@value":"9000006702275"},{"@type":"NRID","@value":"9000414839198"},{"@type":"NRID","@value":"9000020727083"},{"@type":"NRID","@value":"9000252819814"},{"@type":"NRID","@value":"9000392756996"},{"@type":"NRID","@value":"9000021847250"},{"@type":"NRID","@value":"9000243750975"},{"@type":"NRID","@value":"9000020686686"},{"@type":"NRID","@value":"9000254704972"},{"@type":"NRID","@value":"9000255696966"},{"@type":"NRID","@value":"9000020371394"},{"@type":"NRID","@value":"9000311788021"},{"@type":"NRID","@value":"9000391634337"},{"@type":"NRID","@value":"9000254234847"},{"@type":"NRID","@value":"9000253247056"},{"@type":"NRID","@value":"9000255700025"},{"@type":"NRID","@value":"9000255783810"},{"@type":"NRID","@value":"9000253246848"},{"@type":"NRID","@value":"9000256020830"},{"@type":"NRID","@value":"9000256033809"},{"@type":"NRID","@value":"9000020996804"},{"@type":"NRID","@value":"9000392760753"},{"@type":"NRID","@value":"9000256033860"},{"@type":"NRID","@value":"9000006708708"},{"@type":"NRID","@value":"9000020151265"},{"@type":"NRID","@value":"9000253015079"},{"@type":"NRID","@value":"9000253012316"},{"@type":"NRID","@value":"9000256016157"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0014420"}],"foaf:name":[{"@value":"Shoichi Kusumoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319552605957","@type":"Researcher","foaf:name":[{"@value":"Miguel A Valvano"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319552606080","@type":"Researcher","foaf:name":[{"@value":"Simon J Foster"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319552605955","@type":"Researcher","foaf:name":[{"@value":"Tak W Mak"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319552606083","@type":"Researcher","foaf:name":[{"@value":"Gabriel Nuñez"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319552605956","@type":"Researcher","foaf:name":[{"@value":"Naohiro Inohara"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"15292908"},{"@type":"EISSN","@value":"15292916"}],"prism:publicationName":[{"@value":"Nature Immunology"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2003-06-06","prism:volume":"4","prism:number":"7","prism:startingPage":"702","prism:endingPage":"707"},"reviewed":"false","dc:rights":["http://www.springer.com/tdm"],"url":[{"@id":"http://www.nature.com/articles/ni945.pdf"},{"@id":"http://www.nature.com/articles/ni945"}],"createdAt":"2003-06-06","modifiedAt":"2023-05-18","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Lipopolysaccharides","dc:title":"Lipopolysaccharides"},{"@id":"https://cir.nii.ac.jp/all?q=Immunology","dc:title":"Immunology"},{"@id":"https://cir.nii.ac.jp/all?q=Intracellular%20Signaling%20Peptides%20and%20Proteins","dc:title":"Intracellular Signaling Peptides and Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Nod2%20Signaling%20Adaptor%20Protein","dc:title":"Nod2 Signaling Adaptor Protein"},{"@id":"https://cir.nii.ac.jp/all?q=Bacterial%20Infections","dc:title":"Bacterial Infections"},{"@id":"https://cir.nii.ac.jp/all?q=Peptidoglycan","dc:title":"Peptidoglycan"},{"@id":"https://cir.nii.ac.jp/all?q=Diaminopimelic%20Acid","dc:title":"Diaminopimelic Acid"},{"@id":"https://cir.nii.ac.jp/all?q=Immunity,%20Innate","dc:title":"Immunity, Innate"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line","dc:title":"Cell Line"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Nod1%20Signaling%20Adaptor%20Protein","dc:title":"Nod1 Signaling Adaptor Protein"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Cytokines","dc:title":"Cytokines"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=/dk/atira/pure/subjectarea/asjc/2400/2403","dc:title":"/dk/atira/pure/subjectarea/asjc/2400/2403"},{"@id":"https://cir.nii.ac.jp/all?q=Carrier%20Proteins","dc:title":"Carrier Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Adaptor%20Proteins,%20Signal%20Transducing","dc:title":"Adaptor Proteins, Signal Transducing"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050287297262969088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"NOD1 and NOD2 mediate sensing of periodontal pathogens."}]},{"@id":"https://cir.nii.ac.jp/crid/1360002218683559552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cdx2 Expression and Intestinal Metaplasia Induced by\n                    <i>H. pylori</i>\n                    Infection of Gastric Cells Is Regulated by NOD1-Mediated Innate Immune Responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002218805854080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232181276160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Genetic susceptibility to Kawasaki disease: Analysis of pattern recognition receptor genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004237553444352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Commensal Bacteria Regulate Thymic Aire Expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142899582336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Recent advances in self-adjuvanting glycoconjugate vaccines"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017282183054976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Innovative Vaccine Strategy: Self-Adjuvanting Conjugate Vaccines"}]},{"@id":"https://cir.nii.ac.jp/crid/1360022306714504960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Microbial ligand-independent regulation of lymphopoiesis by NOD1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693704962432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification of Pathogenic Cardiac CD11c\n            <sup>+</sup>\n            Macrophages in Nod1-Mediated Acute Coronary Arteritis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707032810112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Immune Receptor NOD1 and Kinase RIP2 Interact with Bacterial Peptidoglycan on Early Endosomes to Promote Autophagy and Inflammatory Signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710686984832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Proinflammatory effects of muramyldipeptide on human gingival fibroblasts"}]},{"@id":"https://cir.nii.ac.jp/crid/1360286996355797248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Caffeic Acid Phenethyl Ester (CAPE) Induces VEGF Expression and Production in Rat Odontoblastic Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165924098176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Sensing of Commensal Organisms by the Intracellular Sensor NOD1 Mediates Experimental Pancreatitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166844166016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synthesis of characteristic Mycobacterium peptidoglycan (PGN) fragments utilizing with chemoenzymatic preparation of meso-diaminopimelic acid (DAP), and their modulation of innate immune responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565170866199808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Human SAP Is a Novel Peptidoglycan Recognition Protein That Induces Complement-Independent Phagocytosis of <i>Staphylococcus aureus</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567179895749888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The pattern‐recognition receptor nucleotide‐binding oligomerization domain–containing protein 1 promotes production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183200727296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Structures, Synthesis, and Human Nod1 Stimulation of Immunostimulatory Bacterial Peptidoglycan Fragments in the Environment"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567184285246080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185663791616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Peptidoglycan and lipopolysaccharide synergistically enhance bone resorption and osteoclastogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186811265024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Applications of reconstituted inflammasomes in a cell-free system to drug discovery and elucidation of the pathogenesis of autoinflammatory diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232425928448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Roles of human trophoblasts’ pattern recognition receptors in host defense and pregnancy complications"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584340532066688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Macrolides Decrease the Proinflammatory Activity of Macrolide-Resistant Streptococcus pneumoniae"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588381081584256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The MraY Inhibitor Muraymycin D2 and Its Derivatives Induce Enlarged Cells in Obligate Intracellular Chlamydia and Wolbachia and Break the Persistence Phenotype in Chlamydia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640863473920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Transcriptome analysis of immune response against Vibrio harveyi infection in orange-spotted grouper (Epinephelus coioides)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641110876672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Peptidoglycan inhibits progesterone and androstenedione production in bovine ovarian theca cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641807491200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Peptidoglycan as Nod1 ligand; fragment structures in the environment, chemical synthesis, and their innate immunostimulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643152425600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A <i>NOD2</i> gene polymorphism is associated with the prevalence and severity of chronic obstructive pulmonary disease in a Japanese population"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643605578880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Functional Roles of NOD1 in Odontoblasts on Dental Pulp Innate Immunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643918020224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The different roles of innate immune receptors in inflammation and carcinogenesis between races"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848654890931584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Peptidoglycan microarray as a novel tool to explore protein–ligand recognition"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848654909160704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Glycan Sequence‐Dependent Nod2 Activation Investigated by Using a Chemically Synthesized Bacterial Peptidoglycan Fragment Library"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656932259456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The crystal structure and oligomeric form of Escherichia coli l , d -carboxypeptidase A"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848661288420480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Role of Muramyl Dipeptide in Lipopolysaccharide-Mediated Biological Activity and Osteoclast Activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848661873267712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Innate Immune Activation and Thyroid Autoimmunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567728810496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Host-microbe cross-talk governs amino acid chirality to regulate survival and differentiation of B cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975841938157824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Role of peptide transporter 2 and MAPK signaling pathways in the innate immune response induced by bacterial peptides in alveolar epithelial cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846259560960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"PYNOD, a novel Apaf‐1/CED4‐like protein is an inhibitor of ASC and caspase‐1"},{"@language":"en","@value":"PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204412743552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"自然免疫系による歯周病原性細菌の認識機構についての解析"},{"@language":"en","@value":"Recognition of Periodontopathic Bacteria by Innate Immune System"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204648334848","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Epithelial cells as sentinels in mucosal immune barrier"},{"@language":"ja","@value":"粘膜免疫系の最前線における上皮細胞の生体防御機構"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205078174976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"1. ウイルス感染に応答したI型インターフェロン遺伝子の発現誘導メカニズム"},{"@language":"en","@value":"Virus-induced expression of type I Interferon genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679123999872","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Key structures of bacterial peptidoglycan and lipopolysaccharide triggering the innate immune system of higher animals: Chemical synthesis and functional studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679627654016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"NOD蛋白質の機能から考える『自己炎症疾患』発症の分子メカニズム"},{"@language":"en","@value":"The molecular mechanism of autoinflammatory disease</br>—Lessons from the function of NOD protein families—"},{"@value":"The molecular mechanism of autoinflammatory disease</br>&mdash;Lessons from the function of NOD protein families&mdash;"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680084621696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Transcriptional Analysis of Intravenous Immunoglobulin Resistance in Kawasaki Disease Using an Induced Pluripotent Stem Cell Disease Model"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680235020928","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The roles of NOD like receptors in inflammation are different between Japanese and Caucasian"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680289579520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthesis and Functional Analysis of the Key Compounds Responsible for Signal Transduction"},{"@value":"生体内の情報伝達に関わる鍵化合物の合成と機能解析"},{"@language":"ja-Kana","@value":"セイタイナイ ノ ジョウホウ デンタツ ニ カカワル カギ カゴウブツ ノ ゴウセイ ト キノウ カイセキ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680316829056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthesis of Bacterial Glycoconjugates and Their Bio-functional Studies in Innate Immunity"},{"@language":"ja","@value":"細菌由来複合糖質の合成と自然免疫研究"},{"@language":"ja-Kana","@value":"サイキン ユライ フクゴウ トウシツ ノ ゴウセイ ト シゼン メンエキ ケンキュウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681401027200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Up-Regulation of NOD1 and NOD2 through TLR4 and TNF-.ALPHA. in LPS-treated Murine Macrophages"},{"@language":"ja","@value":"LPS処理されたマウスのマクロファージにおけるTLR4とTNF-αを介したNOD1とNOD2の発現亢進"},{"@value":"Up-regulation of NOD1 and NOD2 through TLR4 and TNF-α in LPS-treated Murine Macrophages"},{"@language":"ja-Kana","@value":"Up regulation of NOD1 and NOD2 through TLR4 and TNF アルファ in LPS treated Murine Macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681425451520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"Ｎｏｄタンパク質を介する細菌と宿主の相互作用"},{"@language":"en","@value":"Bacteria/host interaction mediated by Nod proteins"},{"@language":"ja-Kana","@value":"Nod タンパクシツ オ カイスル サイキン ト ヤドヌシ ノ ソウゴ サヨウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1520009408589440512","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"ASCとPYRINファミリー:自然免疫とアポトーシスの新たな制御機構"},{"@language":"ja-Kana","@value":"ASC ト PYRIN ファミリー シゼン メンエキ ト アポトーシス ノ アラタ ナ セイギョ キコウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1520010379904816768","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"The innate immune system in the intestine"},{"@language":"ja-Kana","@value":"The innate immune system in the intestine"}]},{"@id":"https://cir.nii.ac.jp/crid/1520010381075149184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Separation and characterization of the immunostimulatory components in unpolished rice black vinegar (kurozu)"}]},{"@id":"https://cir.nii.ac.jp/crid/1520290882228109696","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"細胞質内パターン認識受容体NLRの構造と機能"},{"@language":"ja-Kana","@value":"サイボウシツ ナイ パターン ニンシキ ジュヨウタイ NLR ノ コウゾウ ト キノウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1520573331166672512","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"NLRの介する免疫応答と自己炎症性疾患"},{"@language":"ja-Kana","@value":"NLR ノ カイスル メンエキ オウトウ ト ジコ エンショウセイ シッカン"}]},{"@id":"https://cir.nii.ac.jp/crid/1520854805703013376","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"Mycobacterial Mammalian Cell Entry Protein 1A (Mce1A)-Mediated Adherence Enhances the Chemokine Production by A549 Alveolar Epithelial Cells"},{"@language":"ja-Kana","@value":"Mycobacterial Mammalian Cell Entry Protein 1A Mce1A Mediated Adherence Enhances the Chemokine Production by A549 Alveolar Epithelial Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009749983608192","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Toll-like receptors in innate immunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009749997761408","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mechanism of Immunostimulating Action of Peptidoglycan, Investigation with Synthetic Partial Structures"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009750944366080","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The roles of TLRs, RLRs and NLRs in pathogen recognition"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854175366080384","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The cytosolic pattern-recognition receptor Nod2 and inflammatory granulomatous disorders"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854175394009216","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"細胞内菌体受容体NODと炎症性疾患の解析"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135650535835264","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Lipoprotein is a predominant Toll-like receptor 2 ligand in Staphylococcus aureus cell wall components"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417125571995648","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pathogen recognition by innate receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698600554995840","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthesis of meso-Diaminopimelic Acid for Construction of Gram-negative Bacterial Peptidoglycan Partial Structures"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698600586704768","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Relationship between the in vitro response of dendritic cells to Lactobacillus and prevention of tumorigenesis in the mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261549808471680","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ウイルス感染に応答したI型インタｰフェロン遺伝子の発現誘導メカニズム"},{"@language":"en","@value":"Virus-induced expression of type I Interferon genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261550414425216","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthesis of Potent Immunostimulating Nod1 Ligands : Acylated Diaminopimelic Acid Containing Peptides"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543025592277888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synergism between TLRs and NOD1/2 in Oral Epithelial Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824501057232896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Roles of TLR2, TLR4, NOD2, and NOD1 in Pulp Fibroblasts"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668925003141248","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Protective and Destructive Immunity in the Periodontium : Part 1-Innate and Humoral Immunity and the Periodontium"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950400274688384","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthesis of Fluorescent Probe for Intracellular Innate Immune Receptor Nod1"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950400306782464","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Toll-like Receptors, NOD1, and NOD2 in Oral Epithelial Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231875218641792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Functional TLRs and NODs in Human Gingival Fibroblasts"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/ni945"},{"@type":"CIA","@value":"80016047817"},{"@type":"OPENAIRE","@value":"doi_dedup___::a5079349d9374d0321b8a70ee71abb4a"},{"@type":"CROSSREF","@value":"10.1172/jci39481_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0105904_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1016/j.immuni.2012.05.024_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2018.03.195_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.2492/inflammregen.31.196_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1016/j.tiv.2014.04.005_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1016/j.humimm.2012.03.011_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.2177/jsci.30.68_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1021/np100795d_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1016/j.ddtec.2020.11.006_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1007/978-1-0716-2910-9_5_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1038/s41590-023-01668-x_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1161/atvbaha.114.304846_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1111/j.1600-0765.2009.01217.x_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1155/2019/5390720_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1039/c5ob02145f_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.4049/jimmunol.1300940_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1002/art.34318_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1084/jem.20170497_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1111/j.1600-0765.2011.01452.x_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1186/s41232-017-0040-y_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-16-0541_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1292/jvms.68.471_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.2329/perio.46.94_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1016/j.jri.2023.103811_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1128/spectrum.00148-23_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.3390/antibiotics13050421_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1039/c2np00091a_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1111/j.1440-1843.2011.02069.x_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1155/2016/9325436_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1186/s12199-017-0678-8_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1002/bip.22807_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1002/cbic.201200655_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1155/2018/8047610_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1210/jc.2011-1568_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.5059/yukigoseikyokaishi.70.113_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1016/j.fsi.2017.09.052_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1158/0008-5472.can-15-2272_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.2177/jsci.29.16_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1126/sciadv.abd6480_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.2183/pjab.86.322_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1016/j.chom.2014.04.001_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1016/j.lfs.2019.05.042_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.1016/j.jbiosc.2013.05.029_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"},{"@type":"CROSSREF","@value":"10.2222/jsv.54.161_references_DOI_CFPtC79gTTQ3YHPidhdrFeAVPZj"}]}