{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319554298240.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.cell.2009.10.014"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0092867409013026?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0092867409013026?httpAccept=text/plain"}}],"dc:title":[{"@value":"An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319554298241","@type":"Researcher","foaf:name":[{"@value":"Dimitrios Iliopoulos"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319554298242","@type":"Researcher","foaf:name":[{"@value":"Heather A. Hirsch"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319554298240","@type":"Researcher","foaf:name":[{"@value":"Kevin Struhl"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00928674"}],"prism:publicationName":[{"@value":"Cell"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2009-11","prism:volume":"139","prism:number":"4","prism:startingPage":"693","prism:endingPage":"706"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://www.elsevier.com/open-access/userlicense/1.0/","https://doi.org/10.15223/policy-017","https://doi.org/10.15223/policy-037","https://doi.org/10.15223/policy-012","https://doi.org/10.15223/policy-029","https://doi.org/10.15223/policy-004"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0092867409013026?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0092867409013026?httpAccept=text/plain"}],"createdAt":"2009-10-30","modifiedAt":"2025-09-25","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001335835586688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Non-autonomous overgrowth by oncogenic niche cells: Cellular cooperation and competition in tumorigenesis"},{"@value":"Non‐autonomous overgrowth by oncogenic niche cells: Cellular cooperation and competition in tumorigenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1050025031480679296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"ATM-Mediated DNA Damage Signals Mediate Immune Escape through Integrin-αvβ3-Dependent Mechanisms"}]},{"@id":"https://cir.nii.ac.jp/crid/1050845760669907200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation."}]},{"@id":"https://cir.nii.ac.jp/crid/1050856995323788544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Roles of microRNAs and RNA-Binding Proteins in the Regulation of Colorectal Cancer Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1050869456403944448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Central Roles of STAT3-Mediated Signals in Onset and Development of Cancers : Tumorigenesis and Immunosurveillance"}]},{"@id":"https://cir.nii.ac.jp/crid/1050870696495916160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Acquisition of Interleukin-6 Production Ability Over Time With Pheochromocytoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002219454825600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Assembly of EDC4 and Dcp1a into Processing Bodies Is Critical for the Translational Regulation of IL-6"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233448876288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"NF-κB, inflammation, immunity and cancer: coming of age"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233528402688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The miR-199a/Brm/EGR1 axis is a determinant of anchorage-independent growth in epithelial tumor cell lines"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004234482017152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Human\n                    <i>RGM249</i>\n                    -Derived Small RNAs Potentially Regulate Tumor Malignancy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235567822848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Purvalanol A, a CDK inhibitor, effectively suppresses Src‐mediated transformation by inhibiting both CDKs and c‐Src"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236326467456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"MiR-196a regulates heme oxygenase-1 by silencing Bach1 in the neonatal mouse lung"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236369075456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Let-7 Expression Is a Significant Determinant of Response to Chemotherapy through the Regulation of IL-6/STAT3 Pathway in Esophageal Squamous Cell Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004237519684352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Interleukin-6 Mediates Epithelial–Stromal Interactions and Promotes Gastric Tumorigenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239443845760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"HTLV-1-Mediated Epigenetic Pathway to Adult T-Cell Leukemia–Lymphoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017280645659136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Adipose-derived exosomes block muscular stem cell proliferation in aged mouse by delivering miRNA Let-7d-3p that targets transcription factor HMGA2"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690759497984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Exosomal tumor-suppressive microRNAs as novel cancer therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691780219520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692108211584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693660352256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706312075648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Immune regulation of therapy-resistant niches: emerging targets for improving anticancer drug responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708457598720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tumor suppression via inhibition of SWI/SNF complex-dependent NF-κB activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710465048960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A role of uridylation pathway for blockade of let‐7 micro<scp>RNA</scp> biogenesis by Lin28B"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710528643840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>let‐7</i> and <i>miR‐17‐92</i>: Small‐sized major players in lung cancer development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360286991914837888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617624176128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Overexpression of miR‐199/214 is a distinctive feature of iron‐induced and asbestos‐induced sarcomatoid mesothelioma in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643697370240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166111385856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A multi-targeted approach to suppress tumor-promoting inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166747119360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"MicroRNAs and liver disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181213960960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The role of microRNAs in hepatocarcinogenesis: current knowledge and future prospects"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183478684800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189941897216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Retinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580230630502400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Roles of RNA-binding proteins in immune diseases and cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640782512768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846642076194560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Down-regulation of Forkhead box protein A1 (FOXA1) leads to cancer stem cell-like properties in tamoxifen-resistant breast cancer cells through induction of interleukin-6"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848661787960192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dissecting cellular senescence and SASP in Drosophila"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848662492855168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inhibitory Mechanism of FAT4 Gene Expression in Response to Actin Dynamics during Src-Induced Carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567554067584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tumor Milieu Controlled by RB Tumor Suppressor"}]},{"@id":"https://cir.nii.ac.jp/crid/1361412894120550528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"RNA binding proteins in the control of autoimmune diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1390576745204684544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Physiological and Pathophysiological Role of IL-6/STAT3-Mediated Signal Transduction and STAT3 Binding Partners in Therapeutic Applications"}]},{"@id":"https://cir.nii.ac.jp/crid/1390845702277218816","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"New ICRP Recommendation―New Radiation Protection Principle and Standards"},{"@language":"ja","@value":"ICRP新勧告―新しい放射線防護の考え方と基準"},{"@value":"ICRP新勧告--新しい放射線防護の考え方と基準(第2回)放射線防護の生物学的側面"},{"@language":"ja-Kana","@value":"ICRP シン カンコク アタラシイ ホウシャセン ボウゴ ノ カンガエカタ ト キジュン ダイ2カイ ホウシャセン ボウゴ ノ セイブツガクテキ ソクメン"}]},{"@id":"https://cir.nii.ac.jp/crid/1390852870559573248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Emerging role of signal transducer and activator of transcription 3 (STAT3) in pituitary adenomas"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.cell.2009.10.014"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0123223_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.3390/cancers9100143_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1038/nri.2017.142_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1038/srep08428_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1111/j.1365-2443.2010.01439.x_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1152/ajplung.00428.2015_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0060914_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.3389/fmicb.2018.01686_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1053/j.gastro.2012.07.009_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.3327/jaesjb.52.5_292_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1016/j.jbc.2022.102098_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1038/ncomms3299_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1073/pnas.1106645108_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1007/s10555-014-9501-9_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1038/s41598-017-11806-9_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1111/cas.12721_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1111/j.1349-7006.2010.01707.x_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1016/j.immuni.2019.03.027_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1089/nat.2013.0424_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1111/cas.14405_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1007/s11418-021-01526-w_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1248/bpb.b22-00887_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1038/jhg.2016.53_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1111/cas.12816_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1007/s00535-013-0909-8_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1038/srep01978_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.4252/wjsc.v8.i4.170_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1016/j.semcancer.2022.03.017_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.3390/cells11162618_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1210/jcemcr/luad106_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1074/jbc.m116.763276_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1186/s41232-016-0031-4_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0118336_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1158/0008-5472.can-11-2028_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1158/0008-5472.can-17-2761_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1158/1078-0432.ccr-12-0701_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1507/endocrj.ej21-0106_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.3390/ijms21072450_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1016/j.semcancer.2015.03.006_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1080/25785826.2019.1655192_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1016/j.cell.2013.09.031_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"},{"@type":"CROSSREF","@value":"10.1016/j.addr.2012.07.011_references_DOI_KZkKCaokiKNHgs3LyPYWJXtmyYq"}]}