{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319597154688.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3727/096368915x686841"}},{"identifier":{"@type":"URI","@value":"http://journals.sagepub.com/doi/pdf/10.3727/096368915X686841"}},{"identifier":{"@type":"URI","@value":"http://journals.sagepub.com/doi/full-xml/10.3727/096368915X686841"}}],"dc:title":[{"@value":"Human Umbilical Cord Mesenchymal Stem Cells: A New Era for Stem Cell Therapy"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p> The human umbilical cord is a promising source of mesenchymal stem cells (HUCMSCs). Unlike bone marrow stem cells, HUCMSCs have a painless collection procedure and faster self-renewal properties. Different derivation protocols may provide different amounts and populations of stem cells. Stem cell populations have also been reported in other compartments of the umbilical cord, such as the cord lining, perivascular tissue, and Wharton's jelly. HUCMSCs are noncontroversial sources compared to embryonic stem cells. They can differentiate into the three germ layers that promote tissue repair and modulate immune responses and anticancer properties. Thus, they are attractive autologous or allogenic agents for the treatment of malignant and nonmalignant solid and soft cancers. HUCMCs also can be the feeder layer for embryonic stem cells or other pluripotent stem cells. Regarding their therapeutic value, storage banking system and protocols should be established immediately. This review critically evaluates their therapeutic value, challenges, and future directions for their clinical applications. </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319597154688","@type":"Researcher","foaf:name":[{"@value":"Dah-Ching Ding"}],"jpcoar:affiliationName":[{"@value":"Department of Obstetrics and Gynecology, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien, Taiwan"},{"@value":"Graduate Institute of Medical Science, Tzu Chi University, Hualien, Taiwan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319597154689","@type":"Researcher","foaf:name":[{"@value":"Yu-Hsun Chang"}],"jpcoar:affiliationName":[{"@value":"Graduate Institute of Medical Science, Tzu Chi University, Hualien, Taiwan"},{"@value":"Department of Pediatrics, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien, Taiwan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319597154690","@type":"Researcher","foaf:name":[{"@value":"Woei-Cherng Shyu"}],"jpcoar:affiliationName":[{"@value":"Center for Neuropsychiatry, China Medical University and Hospital, Taichung, Taiwan"},{"@value":"Graduate Institute of Immunology, China Medical University, Taichung, Taiwan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319597154691","@type":"Researcher","foaf:name":[{"@value":"Shinn-Zong Lin"}],"jpcoar:affiliationName":[{"@value":"Center for Neuropsychiatry, China Medical University and Hospital, Taichung, Taiwan"},{"@value":"Graduate Institute of Immunology, China Medical University, Taichung, Taiwan"},{"@value":"China Medical University Beigang Hospital, Yunlin, Taiwan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09636897"},{"@type":"EISSN","@value":"15553892"}],"prism:publicationName":[{"@value":"Cell Transplantation"}],"dc:publisher":[{"@value":"SAGE Publications"}],"prism:publicationDate":"2015-03","prism:volume":"24","prism:number":"3","prism:startingPage":"339","prism:endingPage":"347"},"reviewed":"false","dc:rights":["http://journals.sagepub.com/page/policies/text-and-data-mining-license"],"url":[{"@id":"http://journals.sagepub.com/doi/pdf/10.3727/096368915X686841"},{"@id":"http://journals.sagepub.com/doi/full-xml/10.3727/096368915X686841"}],"createdAt":"2015-04-08","modifiedAt":"2025-03-11","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050294045370220800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Involvement of WNT Signaling in the Regulation of Gestational Age-Dependent Umbilical Cord-Derived Mesenchymal Stem Cell Proliferation"}]},{"@id":"https://cir.nii.ac.jp/crid/1050294045370478080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Gestational Age-Dependent Increase of Survival Motor Neuron Protein in Umbilical Cord-Derived Mesenchymal Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017282468589184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Optimal Intravenous Administration Procedure for Efficient Delivery of Canine Adipose-Derived Mesenchymal Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186306119296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mesenchymal Stem Cells and Metabolic Syndrome: Current Understanding and Potential Clinical Implications"}]},{"@id":"https://cir.nii.ac.jp/crid/1390576689850491008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Regenerative Effect of Umbilical Cord-Derived Mesenchymal Stromal Cells in a Rat Model of Established Limb Ischemia"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.3727/096368915x686841"},{"@type":"CROSSREF","@value":"10.1155/2017/8749751_references_DOI_MHy4BZSKPsGAcbHKYz5BJxrosHK"},{"@type":"CROSSREF","@value":"10.3389/fped.2017.00194_references_DOI_MHy4BZSKPsGAcbHKYz5BJxrosHK"},{"@type":"CROSSREF","@value":"10.3390/ijms232314681_references_DOI_MHy4BZSKPsGAcbHKYz5BJxrosHK"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-22-0257_references_DOI_MHy4BZSKPsGAcbHKYz5BJxrosHK"},{"@type":"CROSSREF","@value":"10.1155/2016/2892840_references_DOI_5aKnP9zYsCk5HHWhZkMs9ySzrg1"}]}