{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319614115968.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1089/ars.2012.4603"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/pdf/10.1089/ars.2012.4603"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/full-xml/10.1089/ars.2012.4603"}}],"dc:title":[{"@value":"Advanced Oxidation Protein Products Activate Intrarenal Renin–Angiotensin System\n                    <i>via</i>\n                    a CD36-Mediated, Redox-Dependent Pathway"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Aims:</jats:italic>\n                    </jats:bold>\n                    Activation of intrarenal renin–angiotensin system (RAS) has a detrimental effect on the progression of chronic kidney diseases (CKDs), although the regulation of intrarenal RAS remains unclear. The aim of the present study was to evaluate the role of advanced oxidation protein products (AOPPs) in intrarenal RAS activation.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:</jats:italic>\n                    </jats:bold>\n                    AOPPs upregulated the expression of almost all components of RAS and increased activity of angiotensin-converting enzyme in cultured proximal tubular epithelial cells. The triggering effect of AOPP-albumin was 100-times stronger than that of unmodified albumin. The effect of AOPP-albumin was mainly mediated by a CD36-dependent, redox-sensitive signaling involving activation of protein kinase Cα, NADPH oxidase, and nuclear factor-κB/activation protein-1. Chronic AOPP–albumin loading in unilateral nephrectomy rats resulted in deposition of AOPPs in renal tubular cells accompanied with local RAS activation and functional perturbations such as increase in urinary albumin excretion. Accumulation of AOPPs was also detected in human renal tubular cells and correlated with expression of angiotensin II in renal biopsies from 19 patients with IgA nephropathy.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Innovation and Conclusion:</jats:italic>\n                    </jats:bold>\n                    This study demonstrated for the first time that AOPPs modified albumin functions as a strong trigger of intrarenal RAS\n                    <jats:italic toggle=\"yes\">via</jats:italic>\n                    a CD36-mediated, redox-dependent pathway. Given the fact that accumulation of AOPPs is prevalent in diabetes and CKD, targeting AOPPs could be a strategy for the therapeutic intervention of CKD.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.</jats:italic>\n                    18, 19–35.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319614115969","@type":"Researcher","foaf:name":[{"@value":"Wei Cao"}],"jpcoar:affiliationName":[{"@value":"Research Institute of Nephrology"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319614115968","@type":"Researcher","foaf:name":[{"@value":"Jie Xu"}],"jpcoar:affiliationName":[{"@value":"Research Institute of Nephrology"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319614115973","@type":"Researcher","foaf:name":[{"@value":"Zhan Mei Zhou"}],"jpcoar:affiliationName":[{"@value":"Research Institute of Nephrology"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319614115970","@type":"Researcher","foaf:name":[{"@value":"Guo Bao Wang"}],"jpcoar:affiliationName":[{"@value":"Research Institute of Nephrology"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319614115971","@type":"Researcher","foaf:name":[{"@value":"Fan Fan Hou"}],"jpcoar:affiliationName":[{"@value":"Research Institute of Nephrology"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319614115972","@type":"Researcher","foaf:name":[{"@value":"Jing Nie"}],"jpcoar:affiliationName":[{"@value":"Research Institute of Nephrology"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"15230864"},{"@type":"EISSN","@value":"15577716"}],"prism:publicationName":[{"@value":"Antioxidants & Redox Signaling"}],"dc:publisher":[{"@value":"SAGE Publications"}],"prism:publicationDate":"2013-01","prism:volume":"18","prism:number":"1","prism:startingPage":"19","prism:endingPage":"35"},"reviewed":"false","dc:rights":["https://journals.sagepub.com/page/policies/text-and-data-mining-license"],"url":[{"@id":"https://journals.sagepub.com/doi/pdf/10.1089/ars.2012.4603"},{"@id":"https://journals.sagepub.com/doi/full-xml/10.1089/ars.2012.4603"}],"createdAt":"2012-06-05","modifiedAt":"2026-03-11","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360294643808481152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Advanced oxidation protein products contribute to chronic kidney disease‐induced muscle atrophy by inducing oxidative stress <i>via</i> CD36/NADPH oxidase pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1390865021801800960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"GWAS Meta-analysis of Kidney Function Traits in Japanese Populations"}]},{"@id":"https://cir.nii.ac.jp/crid/2050588892097690880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Olmesartan protects endothelial cells against oxidative stress-mediated cellular injury"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1089/ars.2012.4603"},{"@type":"CROSSREF","@value":"10.1002/jcsm.12786_references_DOI_BdB9nv9jiqP3dT9CrZI7k6kpjP3"},{"@type":"CROSSREF","@value":"10.2188/jea.je20230281_references_DOI_BdB9nv9jiqP3dT9CrZI7k6kpjP3"},{"@type":"CROSSREF","@value":"10.1007/s10157-015-1111-5_references_DOI_BdB9nv9jiqP3dT9CrZI7k6kpjP3"}]}