{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319627607680.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1155/2019/2419096"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/journals/omcl/2019/2419096.pdf"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/journals/omcl/2019/2419096.xml"}}],"dc:title":[{"@value":"Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Chronic UVB exposure promotes oxidative stress, directly causes molecular damage, and induces aging-related signal transduction, leading to skin photoaging. Dihydrocaffeic acid (DHCA) is a phenolic compound with potential antioxidant capacity and is thus a promising compound for the prevention of UVB-induced skin photodamage. The aim of this study was to evaluate the antioxidant and protective effect of DHCA against oxidative stress, apoptosis, and matrix metalloproteinase (MMP) expression via the mitogen-activated protein kinase (MAPK) signaling pathway on L929 fibroblasts irradiated with UVB. DHCA exhibited high antioxidant capacity on 2,2-diphenyl-1-picrylhydrazyl (DPPH<jats:sup>•</jats:sup>), 2,2-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS<jats:sup>•+</jats:sup>), and xanthine/luminol/xanthine oxidase (XOD) assays and reduced UVB-induced cell death in the neutral red assay. DHCA also modulated oxidative stress by decreasing intracellular reactive oxygen species (ROS) and extracellular hydrogen peroxide (H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>) production, enhancing catalase (CAT) and superoxide dismutase (SOD) activities and reduced glutathione (GSH) levels. Hence, cellular damage was attenuated by DHCA, including lipid peroxidation, apoptosis/necrosis and its markers (loss of mitochondria membrane potential, DNA condensation, and cleaved caspase 9 expression), and MMP-1 expression. Furthermore, DHCA reduced the phosphorylation of MAPK p38. These findings suggest that DHCA can be used in the development of skin care products to prevent UVB-induced skin damage.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319627607813","@type":"Researcher","foaf:name":[{"@value":"Mariana M. Oliveira"}],"jpcoar:affiliationName":[{"@value":"Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá 87020-900, Brazil"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319627607808","@type":"Researcher","foaf:name":[{"@value":"Bianca A. Ratti"}],"jpcoar:affiliationName":[{"@value":"Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá 87020-900, Brazil"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319627607809","@type":"Researcher","foaf:name":[{"@value":"Regina G. Daré"}],"jpcoar:affiliationName":[{"@value":"Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá 87020-900, Brazil"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319627607810","@type":"Researcher","foaf:name":[{"@value":"Sueli O. Silva"}],"jpcoar:affiliationName":[{"@value":"Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá 87020-900, Brazil"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319627607811","@type":"Researcher","foaf:name":[{"@value":"Maria da Conceição T. Truiti"}],"jpcoar:affiliationName":[{"@value":"Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá 87020-900, Brazil"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319627607814","@type":"Researcher","foaf:name":[{"@value":"Tânia Ueda-Nakamura"}],"jpcoar:affiliationName":[{"@value":"Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá 87020-900, Brazil"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319627607812","@type":"Researcher","foaf:name":[{"@value":"Rachel Auzély-Velty"}],"jpcoar:affiliationName":[{"@value":"Centre de Recherches sur les Macromolécules Végétales, Université Grenoble Alpes, Grenoble 38041, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319627607680","@type":"Researcher","foaf:name":[{"@value":"Celso V. Nakamura"}],"jpcoar:affiliationName":[{"@value":"Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá 87020-900, Brazil"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"19420900"},{"@type":"EISSN","@value":"19420994"}],"prism:publicationName":[{"@value":"Oxidative Medicine and Cellular Longevity"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2019-01-17","prism:volume":"2019","prism:startingPage":"1","prism:endingPage":"14"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://downloads.hindawi.com/journals/omcl/2019/2419096.pdf"},{"@id":"http://downloads.hindawi.com/journals/omcl/2019/2419096.xml"}],"createdAt":"2019-01-17","modifiedAt":"2019-01-17","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360853567585324544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Citrulluside H and citrulluside T from young watermelon fruit attenuate ultraviolet B radiation‐induced matrix metalloproteinase expression through the scavenging of generated reactive oxygen species in human dermal fibroblasts"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1155/2019/2419096"},{"@type":"CROSSREF","@value":"10.1111/phpp.12669_references_DOI_I0XSdO420F2Wk0y6qD24Ck5iX95"}]}