{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319654868096.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/s0304-3835(99)00351-1"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0304383599003511?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0304383599003511?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"10737715"}},{"identifier":{"@type":"NAID","@value":"30003130402"}}],"dc:title":[{"@value":"Modifying effects of carotenoids on superoxide and nitric oxide generation from stimulated leukocytes"}],"description":[{"notation":[{"@value":"Excessive and prolonged generation of superoxide (O2-) and nitric oxide (NO) from inflammatory leukocytes is associated with several lifestyle-related diseases, including cancer. In the present study, we screened 19 natural carotenoids for their modifying effects on O2- and NO generation from differentiated human promyelocytic HL-60 cells and mouse macrophage RAW 264.7 cells, respectively. Of the carotenoids tested, halocynthiaxanthin, isolated from oysters, showed the highest suppressive effect on the generation of both free radicals. The inhibitory potencies of certain carotenoids on radical generation markedly exceeded that of beta-carotene. In addition, some important structural moieties regulating radical generation suppression are discussed."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319654868098","@type":"Researcher","foaf:name":[{"@value":"Akira Murakami"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319654868103","@type":"Researcher","foaf:name":[{"@value":"Mamiko Nakashima"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319654868097","@type":"Researcher","foaf:name":[{"@value":"Teruaki Koshiba"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319654868100","@type":"Researcher","foaf:name":[{"@value":"Takashi Maoka"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319654868096","@type":"Researcher","foaf:name":[{"@value":"Hoyoku Nishino"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319654868101","@type":"Researcher","foaf:name":[{"@value":"Masamichi Yano"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319654868099","@type":"Researcher","foaf:name":[{"@value":"Takashi Sumida"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319654868104","@type":"Researcher","foaf:name":[{"@value":"Oe Kyung Kim"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319654868102","@type":"Researcher","foaf:name":[{"@value":"Koichi Koshimizu"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319654867968","@type":"Researcher","foaf:name":[{"@value":"Hajime Ohigashi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03043835"},{"@type":"NCID","@value":"AA00598513"}],"prism:publicationName":[{"@value":"Cancer Letters"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2000-02","prism:volume":"149","prism:number":"1-2","prism:startingPage":"115","prism:endingPage":"123"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0304383599003511?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0304383599003511?httpAccept=text/plain"}],"createdAt":"2002-07-25","modifiedAt":"2020-01-29","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Inflammation","dc:title":"Inflammation"},{"@id":"https://cir.nii.ac.jp/all?q=Macrophages","dc:title":"Macrophages"},{"@id":"https://cir.nii.ac.jp/all?q=HL-60%20Cells","dc:title":"HL-60 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Macrophage%20Activation","dc:title":"Macrophage Activation"},{"@id":"https://cir.nii.ac.jp/all?q=Nitric%20Oxide","dc:title":"Nitric Oxide"},{"@id":"https://cir.nii.ac.jp/all?q=Carotenoids","dc:title":"Carotenoids"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Superoxides","dc:title":"Superoxides"},{"@id":"https://cir.nii.ac.jp/all?q=Leukocytes","dc:title":"Leukocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050025031474688512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Nutraceutical characteristics of the brown seaweed carotenoid fucoxanthin"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004230200511744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The allenic carotenoid fucoxanthin, a novel marine nutraceutical from brown 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