{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319666709376.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1007/s00262-007-0351-y"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1007/s00262-007-0351-y.pdf"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/article/10.1007/s00262-007-0351-y/fulltext.html"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s00262-007-0351-y"}},{"identifier":{"@type":"PMID","@value":"17602226"}}],"dc:title":[{"@value":"Intratumoral injection of inactivated Sendai virus particles elicits strong antitumor activity by enhancing local CXCL10 expression and systemic NK cell activation"}],"description":[{"notation":[{"@value":"We have already demonstrated that inactivated, replication-defective Sendai virus particles (HVJ-E) have a powerful antitumor effect by both the generation of tumor-specific cytotoxic T cells and inhibition of regulatory T cell activity. Here, we report that HVJ-E also has an antitumor effect through non-T cell immunity. Microarray analysis revealed that direct injection of HVJ-E induced the expression of CXCL10 in established Renca tumors. CXCL10 was secreted by dendritic cells in the tumors after HVJ-E injection. Quantitative real-time RT-PCR and immunohistochemistry revealed that CXCR3+ cells (predominantly NK cells) infiltrated the HVJ-E-injected tumors. Moreover, HVJ-E injection caused systemic activation of NK cells and enhanced their cytotoxity against tumor cells. In an in vivo experiment, approximately 50% of tumors were eradicated by HVJ-E injection, and this activity of HVJ-E against Renca tumors was largely abolished by NK cell depletion using anti-asialo GM1 antibody. Since HVJ-E injection induced systemic antitumor immunity by enhancing or correcting the chemokine-chemokine receptor axis, it might be a potential new therapy for cancer."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319666709377","@type":"Researcher","foaf:name":[{"@value":"Atsuko Fujihara"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319666709376","@type":"Researcher","foaf:name":[{"@value":"Masayuki Kurooka"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319666709379","@type":"Researcher","foaf:name":[{"@value":"Tsuneharu Miki"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319666709378","@type":"Researcher","foaf:name":[{"@value":"Yasufumi Kaneda"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03407004"},{"@type":"EISSN","@value":"14320851"}],"prism:publicationName":[{"@value":"Cancer Immunology, Immunotherapy"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2007-06-30","prism:volume":"57","prism:number":"1","prism:startingPage":"73","prism:endingPage":"84"},"reviewed":"false","dc:rights":["https://www.springernature.com/gp/researchers/text-and-data-mining","https://www.springernature.com/gp/researchers/text-and-data-mining"],"url":[{"@id":"https://link.springer.com/content/pdf/10.1007/s00262-007-0351-y.pdf"},{"@id":"https://link.springer.com/article/10.1007/s00262-007-0351-y/fulltext.html"},{"@id":"http://link.springer.com/content/pdf/10.1007/s00262-007-0351-y"}],"createdAt":"2007-06-29","modifiedAt":"2023-05-23","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20BALB%20C","dc:title":"Mice, Inbred BALB C"},{"@id":"https://cir.nii.ac.jp/all?q=Genes,%20Viral","dc:title":"Genes, Viral"},{"@id":"https://cir.nii.ac.jp/all?q=Reverse%20Transcriptase%20Polymerase%20Chain%20Reaction","dc:title":"Reverse Transcriptase Polymerase Chain Reaction"},{"@id":"https://cir.nii.ac.jp/all?q=Virion","dc:title":"Virion"},{"@id":"https://cir.nii.ac.jp/all?q=Fluorescent%20Antibody%20Technique","dc:title":"Fluorescent Antibody Technique"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasms,%20Experimental","dc:title":"Neoplasms, Experimental"},{"@id":"https://cir.nii.ac.jp/all?q=Lymphocyte%20Activation","dc:title":"Lymphocyte Activation"},{"@id":"https://cir.nii.ac.jp/all?q=Immunohistochemistry","dc:title":"Immunohistochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Sendai%20virus","dc:title":"Sendai virus"},{"@id":"https://cir.nii.ac.jp/all?q=Chemokine%20CXCL10","dc:title":"Chemokine CXCL10"},{"@id":"https://cir.nii.ac.jp/all?q=Killer%20Cells,%20Natural","dc:title":"Killer Cells, Natural"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Immunotherapy","dc:title":"Immunotherapy"},{"@id":"https://cir.nii.ac.jp/all?q=RNA,%20Messenger","dc:title":"RNA, Messenger"},{"@id":"https://cir.nii.ac.jp/all?q=Oligonucleotide%20Array%20Sequence%20Analysis","dc:title":"Oligonucleotide Array Sequence Analysis"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050853365585553152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Hemagglutinating virus of Japan‐envelope containing programmed cell death‐ligand 1 siRNA inhibits immunosuppressive activities and elicits antitumor immune responses in 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