{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319680610176.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1530/rep-10-0113"}},{"identifier":{"@type":"URI","@value":"https://rep.bioscientifica.com/view/journals/rep/140/1/143.xml"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/reproduction/article-pdf/140/1/143/64532075/143.pdf"}}],"dc:title":[{"@value":"The effect of elevated progesterone and pregnancy status on mRNA expression and localisation of progesterone and oestrogen receptors in the bovine uterus"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>To investigate the effects of pregnancy or post-ovulatory progesterone (P4) supplementation on the expression of oestrogen and P4 receptors (ESRs and PGRs) in the bovine uterus, heifers (n=263) were randomly assigned to the following treatments: i) cyclic, normal P4; ii) cyclic, high P4; iii) pregnant, normal P4; and iv) pregnant, high P4 on days 5, 7, 13 and 16 of pregnancy/oestrous cycle. Elevated P4 was achieved through P4-releasing intravaginal device insertion on day 3 after oestrus, resulting in increased concentrations from day 3.5 to 8 (P&lt;0.05) in the high groups than in the normal groups. Irrespective of treatment, PGR and ESR1 mRNA expressions were highest on days 5 and 7 and decreased on day 13 (P&lt;0.05), while ESR2 mRNA expression increased on day 7 (P&lt;0.05) and similar levels were maintained within the normal P4 groups subsequently. Expression in the high P4 groups decreased on day 13 (P&lt;0.05). PGR-AB and PGR-B protein expressions were high in the luminal and superficial glands on days 5 and 7, but by day 13, expression had declined to very low or undetectable levels and high P4 concentration tended to decrease or decreased significantly (P&lt;0.05) the expression in these regions on days 5 and 7. ESR1 protein expression was high, with no treatment effect. ESR2 protein was also highly expressed, with no clear effect of treatment. In conclusion, early post-ovulatory P4 supplementation advances the disappearance of PGR protein from the luminal epithelium on days 5 and 7, and decreases ESR2 mRNA expression during the mid-luteal phase, but has no effect on PGR or ESR1 mRNA expression.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380007827208889478","@type":"Researcher","foaf:name":[{"@value":"L A Okumu"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319680610176","@type":"Researcher","foaf:name":[{"@value":"N Forde"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319680610177","@type":"Researcher","foaf:name":[{"@value":"A G Fahey"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319680610181","@type":"Researcher","foaf:name":[{"@value":"E Fitzpatrick"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319680610178","@type":"Researcher","foaf:name":[{"@value":"J F Roche"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319680610182","@type":"Researcher","foaf:name":[{"@value":"M A Crowe"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319680610179","@type":"Researcher","foaf:name":[{"@value":"P Lonergan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"14701626"},{"@type":"EISSN","@value":"17417899"}],"prism:publicationName":[{"@value":"Reproduction"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2010-07-01","prism:volume":"140","prism:number":"1","prism:startingPage":"143","prism:endingPage":"153"},"reviewed":"false","dc:rights":["https://academic.oup.com/pages/standard-publication-reuse-rights"],"url":[{"@id":"https://rep.bioscientifica.com/view/journals/rep/140/1/143.xml"},{"@id":"https://academic.oup.com/reproduction/article-pdf/140/1/143/64532075/143.pdf"}],"createdAt":"2010-04-19","modifiedAt":"2026-01-07","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285711766537472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Differential neutrophil gene expression in early bovine pregnancy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567187890809088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Activation of lysosomal cathepsins in pregnant bovine leukocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206336685568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Transcriptomic Analysis of the Bovine Endometrium: What is Required to Establish Uterine Receptivity to Implantation in Cattle ?"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206431193216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Differences in progesterone concentrations and mRNA expressions of progesterone receptors in bovine endometrial tissue between the uterine horns ipsilateral and contralateral to the corpus luteum"}]},{"@id":"https://cir.nii.ac.jp/crid/1390587284580390400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of luteal blood flow on endometrial progesterone concentrations and gene expression in Japanese Black cows"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1530/rep-10-0113"},{"@type":"CROSSREF","@value":"10.1186/1477-7827-11-6_references_DOI_CORAZedxPnQBeM6VgZ24FHy6H4H"},{"@type":"CROSSREF","@value":"10.1262/jrd.2011-021_references_DOI_CORAZedxPnQBeM6VgZ24FHy6H4H"},{"@type":"CROSSREF","@value":"10.1530/rep-18-0078_references_DOI_CORAZedxPnQBeM6VgZ24FHy6H4H"},{"@type":"CROSSREF","@value":"10.1262/jrd.2025-032_references_DOI_CORAZedxPnQBeM6VgZ24FHy6H4H"},{"@type":"CROSSREF","@value":"10.1292/jvms.15-0366_references_DOI_CORAZedxPnQBeM6VgZ24FHy6H4H"}]}