{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319705953536.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1523/jneurosci.17-15-05820.1997"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1523/JNEUROSCI.17-15-05820.1997"}}],"dc:title":[{"@value":"Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Neurons and glia are generated throughout adulthood from proliferating cells in two regions of the rat brain, the subventricular zone (SVZ) and the hippocampus. This study shows that exogenous basic fibroblast growth factor (FGF-2) and epidermal growth factor (EGF) have differential and site-specific effects on progenitor cells<jats:italic>in vivo</jats:italic>. Both growth factors expanded the SVZ progenitor population after 2 weeks of intracerebroventricular administration, but only FGF-2 induced an increase in the number of newborn cells, most prominently neurons, in the olfactory bulb, the normal destination for neuronal progenitors migrating from the SVZ. EGF, on the other hand, reduced the total number of newborn neurons reaching the olfactory bulb and substantially enhanced the generation of astrocytes in the olfactory bulb. Moreover, EGF increased the number of newborn cells in the striatum either by migration of SVZ cells or by stimulation of local progenitor cells. No evidence of neuronal differentiation of newborn striatal cells was found by three-dimensional confocal analysis, although many of these newborn cells were associated closely with striatal neurons. The proliferation of hippocampal progenitors was not affected by either growth factor. However, EGF increased the number of newborn glia and reduced the number of newborn neurons, similar to the effects seen in the olfactory bulb. These findings may be useful for elucidating the<jats:italic>in vivo</jats:italic>role of growth factors in neurogenesis in the adult CNS and may aid development of neuronal replacement strategies after brain damage.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319705953539","@type":"Researcher","foaf:name":[{"@value":"H. Georg Kuhn"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319705953536","@type":"Researcher","foaf:name":[{"@value":"Jürgen Winkler"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319705953538","@type":"Researcher","foaf:name":[{"@value":"Gerd Kempermann"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319705953540","@type":"Researcher","foaf:name":[{"@value":"Leon J. Thal"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319705953537","@type":"Researcher","foaf:name":[{"@value":"Fred H. Gage"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02706474"},{"@type":"EISSN","@value":"15292401"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/02706474"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/02706474"}],"prism:publicationName":[{"@value":"The Journal of Neuroscience"}],"dc:publisher":[{"@value":"Society for Neuroscience"}],"prism:publicationDate":"1997-08-01","prism:volume":"17","prism:number":"15","prism:startingPage":"5820","prism:endingPage":"5829"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by-nc-sa/4.0/"],"url":[{"@id":"https://syndication.highwire.org/content/doi/10.1523/JNEUROSCI.17-15-05820.1997"}],"createdAt":"2018-04-05","modifiedAt":"2023-04-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002215839065600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Temporal changes in the response of SVZ neural stem cells to intraventricular administration of growth factors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002216095170176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Attenuation of Notch signaling promotes the differentiation of neural progenitors into neurons in the hippocampal CA1 region after ischemic injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235622738688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Differential responses of endogenous adult mouse neural precursors to excess neuronal excitation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236979330560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Macrophage migration inhibitory factor (MIF) promotes cell survival and proliferation of neural stem/progenitor cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005518378563456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neural stem cell phenotype of tanycyte-like ependymal cells in the circumventricular organs and central canal of adult mouse brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181951838208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The hydrophobic dipeptide Leu–Ile inhibits immobility induced by repeated forced swimming via the induction of BDNF"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185452318464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Fractone‐heparan sulphates mediate FGF‐2 stimulation of cell proliferation in the adult subventricular zone"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204868850048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"5. 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