{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319726192640.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/jmv.20411"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjmv.20411"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.20411"}},{"identifier":{"@type":"PMID","@value":"16032734"}}],"dc:title":[{"@value":"Distinct geographic distributions of hepatitis B virus genotypes in patients with acute infection in Japan"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Genotypes of hepatitis B virus (HBV) were determined in 145 patients with acute hepatitis B from various districts in Japan to establish their geographic distribution and evaluating the influence on the clinical illness and outcome. Genotypes were A in 27 (19%) patients, B in 8 (5%), C in 109 (75%) and mixed with B and C in the remaining one (1%). Genotype A was more frequent in metropolitan than the other areas (21/69 (30%) vs. 6/76 (8%), <jats:italic>P</jats:italic> < 0.001). On phylogenetic analysis, seven of the nine (78%) HBV/A isolates selected at random clustered with those from Europe and the United States, while the remaining two with those of subgroup A' prevalent in Asia and Africa. Maximum ALT levels were lower (2069 ± 1075 vs. 2889 ± 1867 IU/L, <jats:italic>P</jats:italic> = 0.03) and baseline HBV DNA titers were higher (5.90 ± 1.45 vs. 5.13 ± 1.36 log genome equivalents (LGE)/ml, <jats:italic>P</jats:italic> = 0.002) in patients infected with genotype A than C. Hepatitis B surface antigen persisted longer in patients infected with genotype A than C (1.95 ± 1.09 vs. 1.28 ± 1.42 months, <jats:italic>P</jats:italic> = 0.02). HBV infection became chronic in one (4%) patient with genotype A and one (1%) with genotype C infection. Fulminant hepatic failure developed in none of the patients with genotype A, one (13%) with genotype B and five (5%) with genotype C. The point mutation in the precore region (A1896) or the double mutations in the basic core promoter (BCP) region (T1762/A1764) were detected in none of the patients with genotype A, two (25%) with genotype B and 27 (26%) with genotype C. In conclusion, genotype A is frequent in patients with acute hepatitis B in metropolitan areas of Japan, probably reflecting particular transmission routes, and associated with longer and milder clinical course than genotype C. J. Med. Virol. 77:39–46, 2005. © 2005 Wiley‐Liss, Inc.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319726192513","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Yotsuyanagi"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319726192644","@type":"Researcher","foaf:name":[{"@value":"Chiaki Okuse"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319726192642","@type":"Researcher","foaf:name":[{"@value":"Kiyomi Yasuda"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319726192651","@type":"Researcher","foaf:name":[{"@value":"Etsuro Orito"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319726192646","@type":"Researcher","foaf:name":[{"@value":"Shuhei Nishiguchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319726192648","@type":"Researcher","foaf:name":[{"@value":"Joji Toyoda"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319726192641","@type":"Researcher","foaf:name":[{"@value":"Eiichi Tomita"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319726192647","@type":"Researcher","foaf:name":[{"@value":"Keisuke Hino"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319726192512","@type":"Researcher","foaf:name":[{"@value":"Kiwamu Okita"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319726192649","@type":"Researcher","foaf:name":[{"@value":"Shiro Murashima"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319726192643","@type":"Researcher","foaf:name":[{"@value":"Michio Sata"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319726192640","@type":"Researcher","foaf:name":[{"@value":"Hiromi Hoshino"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319726192650","@type":"Researcher","foaf:name":[{"@value":"Yuzo Miyakawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319726192645","@type":"Researcher","foaf:name":[{"@value":"Shiro Iino"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01466615"},{"@type":"EISSN","@value":"10969071"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/01466615"}],"prism:publicationName":[{"@value":"Journal of Medical Virology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2005-07-19","prism:volume":"77","prism:number":"1","prism:startingPage":"39","prism:endingPage":"46"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjmv.20411"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.20411"}],"createdAt":"2005-07-19","modifiedAt":"2023-10-08","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Hepatitis%20B%20virus","dc:title":"Hepatitis B virus"},{"@id":"https://cir.nii.ac.jp/all?q=Genotype","dc:title":"Genotype"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Hepatitis%20B%20Core%20Antigens","dc:title":"Hepatitis B Core Antigens"},{"@id":"https://cir.nii.ac.jp/all?q=Japan","dc:title":"Japan"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Multicenter%20Studies%20as%20Topic","dc:title":"Multicenter Studies as Topic"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Phylogeny","dc:title":"Phylogeny"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004231533994112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A pediatric case of hepatitis B virus subgenotype A2 in 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HBV起因B型慢性肝炎の1例"},{"@value":"症例報告 肝細胞癌を合併した非線維化NASH及び遺伝子型AeHBV起因B型慢性肝炎の1例"},{"@language":"ja-Kana","@value":"ショウレイ ホウコク キモ サイボウガン オ ガッペイ シタ ヒセンイカ NASH オヨビ イデンシガタ AeHBV キイン Bガタ マンセイ カンエン ノ 1レイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204795693056","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Distribution of hepatitis B viral genotypes in Japan"},{"@language":"ja","@value":"わが国におけるB型肝炎ウイルス遺伝子型の分布"},{"@value":"Editorial わが国におけるB型肝炎ウイルス遺伝子型の分布"},{"@language":"ja-Kana","@value":"Editorial ワガクニ ニ オケル Bガタ カンエン ウイルス イデンシガタ ノ ブンプ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204870288512","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"An Adult Patient with Acute Infection with Hepatitis B Virus Genotype C that Progressed to Chronic 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我国に於ける急性B型肝炎の最近の動向"},{"@language":"ja-Kana","@value":"Editorial ワガクニ ニ オケル キュウセイ Bガタ カンエン ノ サイキン ノ ドウコウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679771053440","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A case of acute hepatitis B associated with secondary syphilis"},{"@language":"ja","@value":"皮膚梅毒を合併したＧｅｎｏｔｙｐｅ　Ａ，Ｂ型急性肝炎の１例"},{"@value":"症例報告 皮膚梅毒を合併したGenotype A,B型急性肝炎の1例"},{"@language":"ja-Kana","@value":"ショウレイ ホウコク ヒフ バイドク オ ガッペイ シタ Genotype A Bガタ キュウセイ カンエン ノ 1レイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679771190016","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Usefulness of quantitative HBsAg in outcome prediction of acute hepatitis B"},{"@language":"ja","@value":"Ｂ型急性肝炎の経過予測におけるＨＢｓ抗原定量の有用性"},{"@language":"ja-Kana","@value":"Bガタ キュウセイ カンエン ノ ケイカ ヨソク ニ オケル HBs コウゲン テイリョウ ノ 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