{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319735196800.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/j.1468-3083.2009.03419.x"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1468-3083.2009.03419.x"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1468-3083.2009.03419.x"}}],"dc:title":[{"@value":"Soluble immune receptor serum levels are associated with age, but not with clinical phenotype or disease severity in childhood atopic dermatitis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p><jats:bold>Background </jats:bold> Soluble immune receptors (SIRs) have been proposed as biomarkers in patients with atopic dermatitis (AD). However, their clinical applicability in affected children has rarely been studied.</jats:p><jats:p><jats:bold>Objective </jats:bold> To assess the diagnostic usefulness of serum SIRs in childhood AD by correlating the obtained receptor profiles with serological parameters and clinical features such as age, AD phenotype and disease severity.</jats:p><jats:p><jats:bold>Methods </jats:bold> We investigated 100 children with AD. The sCD14, sCD23, sCD25, sCD30, total IgE (tIgE) and eosinophilic cationic protein (ECP) were determined using sera of all children. The clinical phenotype was classified as extrinsic AD (ADe) or intrinsic AD (ADi) by the presence of allergen‐specific IgE antibodies.</jats:p><jats:p><jats:bold>Results </jats:bold> A total of 55 male and 45 female children were recruited. The sCD23, sCD25 and sCD30 serum levels revealed significant age‐dependency. At a mean SCORAD of 40 (range 8–98), none of the evaluated SIRs was correlated to disease severity. In all, 73% of patients suffered from ADe while 27% showed the ADi phenotype. None of the analysed SIRs differed significantly between ADe and ADi patients, while tIgE and ECP levels were elevated in the ADe subgroup.</jats:p><jats:p><jats:bold>Conclusion </jats:bold> The current study provides evidence that sCD23, sCD25 and sCD30 serum levels are highly age‐dependent. Serum concentrations of all investigated SIRs did not significantly correlate with disease severity in children with AD and were not differentially expressed in patients of different AD phenotypes. Therefore, we believe that the studied SIRs cannot be regarded as clinically useful biomarkers for the assessment of childhood AD.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319735196802","@type":"Researcher","foaf:name":[{"@value":"H Ott"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319735196803","@type":"Researcher","foaf:name":[{"@value":"J Wilke"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319735196801","@type":"Researcher","foaf:name":[{"@value":"J M Baron"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319735196804","@type":"Researcher","foaf:name":[{"@value":"PH Höger"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016975530824576","@type":"Researcher","foaf:name":[{"@value":"R Fölster‐Holst"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09269959"},{"@type":"EISSN","@value":"14683083"}],"prism:publicationName":[{"@value":"Journal of the European Academy of Dermatology and Venereology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2010-03-05","prism:volume":"24","prism:number":"4","prism:startingPage":"395","prism:endingPage":"402"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1468-3083.2009.03419.x"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1468-3083.2009.03419.x"}],"createdAt":"2009-09-09","modifiedAt":"2023-11-02","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004232266146816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"High frequencies of positive nickel/cobalt patch tests and high sweat nickel concentration in patients with intrinsic atopic dermatitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165959046016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: Possible immunological state of the intrinsic type"}]},{"@id":"https://cir.nii.ac.jp/crid/1390290868754908800","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Subtypes of atopic dermatitis: From phenotype to endotype"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/j.1468-3083.2009.03419.x"},{"@type":"CROSSREF","@value":"10.1016/j.jdermsci.2013.07.009_references_DOI_RRjEc2ytBHCbH10YduQTJdcoC7Y"},{"@type":"CROSSREF","@value":"10.1016/j.jdermsci.2012.04.004_references_DOI_RRjEc2ytBHCbH10YduQTJdcoC7Y"},{"@type":"CROSSREF","@value":"10.1016/j.alit.2021.07.003_references_DOI_RRjEc2ytBHCbH10YduQTJdcoC7Y"}]}