{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319789615744.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.cmet.2008.04.001"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1550413108001113?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1550413108001113?httpAccept=text/plain"}}],"dc:title":[{"@value":"The Cholesterol Absorption Inhibitor Ezetimibe Acts by Blocking the Sterol-Induced Internalization of NPC1L1"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319789615750","@type":"Researcher","foaf:name":[{"@value":"Liang Ge"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319789615744","@type":"Researcher","foaf:name":[{"@value":"Jing Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319789615751","@type":"Researcher","foaf:name":[{"@value":"Wei Qi"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319789615748","@type":"Researcher","foaf:name":[{"@value":"Hong-Hua Miao"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319789615745","@type":"Researcher","foaf:name":[{"@value":"Jian Cao"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319789615746","@type":"Researcher","foaf:name":[{"@value":"Yu-Xiu Qu"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319789615747","@type":"Researcher","foaf:name":[{"@value":"Bo-Liang Li"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319789615749","@type":"Researcher","foaf:name":[{"@value":"Bao-Liang Song"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"15504131"}],"prism:publicationName":[{"@value":"Cell Metabolism"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2008-06","prism:volume":"7","prism:number":"6","prism:startingPage":"508","prism:endingPage":"519"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/open-access/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S1550413108001113?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S1550413108001113?httpAccept=text/plain"}],"createdAt":"2008-06-04","modifiedAt":"2021-09-11","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050025031474384128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A new system to evaluate characteristics of Niemann-Pick C1 Like 1-mediated cholesterol transport using Xenopus laevis oocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1050869456404546944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Transport via Niemann-Pick C1 Like 1 contributes to the intestinal absorption of ubiquinone"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004237547742080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Luteolin and Quercetin Affect the Cholesterol Absorption Mediated by Epithelial Cholesterol Transporter Niemann–Pick C1-Like 1 in Caco-2 Cells and Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004237561028480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Fomiroid A, a Novel Compound from the Mushroom Fomitopsis nigra, Inhibits NPC1L1-Mediated Cholesterol Uptake via a Mode of Action Distinct from That of Ezetimibe"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005521886124032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pathophysiological importance of bile cholesterol reabsorption: hepatic NPC1L1-exacerbated steatosis and decreasing VLDL-TG secretion in mice fed a high-fat diet"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283694446568192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Ezetimibe Promotes Brush Border Membrane-to-Lumen Cholesterol Efflux in the Small Intestine"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169642425600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Remodeling of\n                    <scp>ER</scp>\n                    ‐exit sites initiates a membrane supply pathway for autophagosome biogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181289217536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Ezetimibe Inhibits Lymphatic Transport of Esterified Cholesterol but Not Free Cholesterol in Thoracic Lymph Duct-Cannulated Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181968769280","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Structure–activity relationship study of non-steroidal NPC1L1 ligands identified through cell-based assay using pharmacological chaperone effect as a readout"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186825054336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Modulation of lipid metabolism with the overexpression of NPC1L1 in mouse liver"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640707780480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"An ultra performance liquid chromatographic method for determining phytosterol uptake by Caco-2 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641738337792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification of the Niemann-Pick C1–like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848661802043264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848664440875648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A Newly Integrated Model for Intestinal Cholesterol Absorption and Efflux Reappraises How Plant Sterol Intake Reduces Circulating Cholesterol Levels"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869855583878528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Importance of Considering Fed-State Gastrointestinal Physiology in Predicting the Reabsorption of Enterohepatic Circulation of Drugs"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204433357568","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Molecular Mechanisms of Ezetimibe-Induced Attenuation of Postprandial Hypertriglyceridemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679609576320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"An Approach to Improve Intestinal Absorption of Poorly Absorbed Water-Insoluble Components <i>via</i> Niemann–Pick C1-Like 1"},{"@value":"An Approach to Improve Intestinal Absorption of Poorly Absorbed Water-Insoluble Components via Niemann-Pick C1-Like 1"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282763111633024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Efficacy and Safety of Ezetimibe in Combination with Atorvastatin for Acute Coronary Syndrome Patients Accompanied with Type 2 Diabetes: A Single-Center, Non-randomized Cohort Study"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.cmet.2008.04.001"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0097901_references_DOI_7BB5vKs8vcb1pBKCiBFeCAwzFM8"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0116162_references_DOI_7BB5vKs8vcb1pBKCiBFeCAwzFM8"},{"@type":"CROSSREF","@value":"10.1186/s12944-019-1179-0_references_DOI_7BB5vKs8vcb1pBKCiBFeCAwzFM8"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0152207_references_DOI_7BB5vKs8vcb1pBKCiBFeCAwzFM8"},{"@type":"CROSSREF","@value":"10.5551/jat.4929_references_DOI_7BB5vKs8vcb1pBKCiBFeCAwzFM8"},{"@type":"CROSSREF","@value":"10.1016/j.dmpk.2020.08.002_references_DOI_7BB5vKs8vcb1pBKCiBFeCAwzFM8"},{"@type":"CROSSREF","@value":"10.15252/embr.201744559_references_DOI_7BB5vKs8vcb1pBKCiBFeCAwzFM8"},{"@type":"CROSSREF","@value":"10.1007/s10557-012-6403-3_references_DOI_7BB5vKs8vcb1pBKCiBFeCAwzFM8"},{"@type":"CROSSREF","@value":"10.1194/jlr.m026575_references_DOI_7BB5vKs8vcb1pBKCiBFeCAwzFM8"},{"@type":"CROSSREF","@value":"10.1016/j.ab.2011.10.051_references_DOI_7BB5vKs8vcb1pBKCiBFeCAwzFM8"},{"@type":"CROSSREF","@value":"10.1101/168518_references_DOI_7BB5vKs8vcb1pBKCiBFeCAwzFM8"},{"@type":"CROSSREF","@value":"10.1038/nm.2581_references_DOI_7BB5vKs8vcb1pBKCiBFeCAwzFM8"},{"@type":"CROSSREF","@value":"10.1194/jlr.m089201_references_DOI_7BB5vKs8vcb1pBKCiBFeCAwzFM8"},{"@type":"CROSSREF","@value":"10.1248/bpb.b15-00359_references_DOI_7BB5vKs8vcb1pBKCiBFeCAwzFM8"},{"@type":"CROSSREF","@value":"10.3390/nu11020310_references_DOI_7BB5vKs8vcb1pBKCiBFeCAwzFM8"},{"@type":"CROSSREF","@value":"10.1016/j.bbamem.2020.183508_references_DOI_7BB5vKs8vcb1pBKCiBFeCAwzFM8"},{"@type":"CROSSREF","@value":"10.1248/cpb.c18-00685_references_DOI_7BB5vKs8vcb1pBKCiBFeCAwzFM8"},{"@type":"CROSSREF","@value":"10.1007/s11095-024-03669-3_references_DOI_7BB5vKs8vcb1pBKCiBFeCAwzFM8"},{"@type":"CROSSREF","@value":"10.1016/j.bmc.2014.05.022_references_DOI_7BB5vKs8vcb1pBKCiBFeCAwzFM8"}]}