{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319834935552.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.archoralbio.2008.02.008"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0003996908000447?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0003996908000447?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"18371934"}}],"dc:title":[{"@value":"Effect of experimental diabetes on craniofacial growth in rats"}],"description":[{"notation":[{"@value":"The goal of this study was to assess the effect of type 1 diabetes mellitus (T1DM) on the craniofacial growth and skeletal maturation using the STZ-DM rat model.Experimental T1DM was induced in 3-week-old male Wistar rats by a single dose of 60 mg/kg body weight of streptozotocin (STZ). Lateral and dorsoventral X-rays of the head were taken at the age of 7 weeks. The X-rays were scanned, digitised and selected linear distances were measured and analysed statistically.In STZ-DM statistical analysis of results revealed a reduction in growth of most of the linear measurements in the neurocranium and mandible by X-ray analysis, and all measurements were significantly lower in viscerocranium.Uncontrolled T1DM reduces craniofacial growth, resulting in retardation of skeletal development."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319834935554","@type":"Researcher","foaf:name":[{"@value":"Mona Aly Abbassy"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319834935552","@type":"Researcher","foaf:name":[{"@value":"Ippei Watari"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319834935553","@type":"Researcher","foaf:name":[{"@value":"Kunimichi Soma"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00039969"}],"prism:publicationName":[{"@value":"Archives of Oral Biology"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2008-09","prism:volume":"53","prism:number":"9","prism:startingPage":"819","prism:endingPage":"825"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","https://doi.org/10.15223/policy-017","https://doi.org/10.15223/policy-037","https://doi.org/10.15223/policy-012","https://doi.org/10.15223/policy-029","https://doi.org/10.15223/policy-004"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0003996908000447?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0003996908000447?httpAccept=text/plain"}],"createdAt":"2008-03-27","modifiedAt":"2025-09-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Blood%20Glucose","dc:title":"Blood Glucose"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Cephalometry","dc:title":"Cephalometry"},{"@id":"https://cir.nii.ac.jp/all?q=Body%20Weight","dc:title":"Body Weight"},{"@id":"https://cir.nii.ac.jp/all?q=Skull","dc:title":"Skull"},{"@id":"https://cir.nii.ac.jp/all?q=Diabetes%20Mellitus,%20Experimental","dc:title":"Diabetes Mellitus, Experimental"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Radiography","dc:title":"Radiography"},{"@id":"https://cir.nii.ac.jp/all?q=Random%20Allocation","dc:title":"Random Allocation"},{"@id":"https://cir.nii.ac.jp/all?q=Diabetes%20Mellitus,%20Type%201","dc:title":"Diabetes Mellitus, Type 1"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Wistar","dc:title":"Rats, Wistar"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004231982442240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Intermittent hypoxia induces disturbances in craniofacial growth and defects in craniofacial morphology"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283695281127424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Influence of differences in the hardness and calcium content of diets on the growth of craniofacial bone in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092564302976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Intermittent hypoxia inhibits mandibular cartilage growth with reduced TGF-β and SOX9 expressions in neonatal rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640740643584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effect of dietary calcium deficiency and altered diet hardness on the jawbone growth: A micro-CT and bone histomorphometric study in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656912550144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impairment of nasal airway under intermittent hypoxia during growth period in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657196016256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Diabetes detrimental effects on enamel and dentine formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657339955712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Unilateral nasal obstruction induces morphological changes of the mandibular condyle in growing rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658338026496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Calcitonin and vitamin D3 have high therapeutic potential for improving diabetic mandibular growth"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707382372608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Effect of Two-Generation Exposure to a High-Fat Diet on Craniofacial Morphology in Rats"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.archoralbio.2008.02.008"},{"@type":"OPENAIRE","@value":"doi_dedup___::96ecfc9d4bdd304a185150162c0c0eea"},{"@type":"CROSSREF","@value":"10.1016/j.archoralbio.2015.10.017_references_DOI_UOpHrke6FpFxOeQ0XXcowtdUiY4"},{"@type":"CROSSREF","@value":"10.1016/j.jdent.2015.01.005_references_DOI_UOpHrke6FpFxOeQ0XXcowtdUiY4"},{"@type":"CROSSREF","@value":"10.1016/j.archoralbio.2014.06.005_references_DOI_UOpHrke6FpFxOeQ0XXcowtdUiY4"},{"@type":"CROSSREF","@value":"10.1016/j.archoralbio.2016.08.036_references_DOI_UOpHrke6FpFxOeQ0XXcowtdUiY4"},{"@type":"CROSSREF","@value":"10.1038/s41598-020-80303-3_references_DOI_UOpHrke6FpFxOeQ0XXcowtdUiY4"},{"@type":"CROSSREF","@value":"10.1016/j.odw.2018.05.001_references_DOI_UOpHrke6FpFxOeQ0XXcowtdUiY4"},{"@type":"CROSSREF","@value":"10.1038/ijos.2015.47_references_DOI_UOpHrke6FpFxOeQ0XXcowtdUiY4"},{"@type":"CROSSREF","@value":"10.3390/jcm12051903_references_DOI_UOpHrke6FpFxOeQ0XXcowtdUiY4"},{"@type":"CROSSREF","@value":"10.2319/102214-765.1_references_DOI_UOpHrke6FpFxOeQ0XXcowtdUiY4"}]}