{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319950324736.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1113/jp270646"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1113%2FJP270646"}},{"identifier":{"@type":"URI","@value":"https://physoc.onlinelibrary.wiley.com/doi/pdf/10.1113/JP270646"}}],"dc:title":[{"@value":"Exercise‐induced oxidative stress: past, present and future"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec><jats:title>Abstract</jats:title><jats:p>The existence of free radicals in living cells was first reported in 1954 and this important finding helped launch the field of free radical biology. However, the discovery that muscular exercise is associated with increased biomarkers of oxidative stress did not occur until 1978. Following the initial report that exercise promotes oxidative stress in humans, many studies have confirmed that prolonged or short‐duration high intensity exercise results in increased radical production in active skeletal muscles resulting in the formation of oxidized lipids and proteins in the working muscles. Since these early descriptive studies, the investigation of radicals and redox biology related to exercise and skeletal muscle has grown as a discipline and the importance of this research in the biomedical sciences is widely recognized. This review will briefly summarize the history of research in exercise‐induced oxidative stress and will discuss the major paradigm shifts that the field has undergone and continues to experience. We conclude with a discussion of future directions in the hope of stimulating additional research in this important field.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319950324737","@type":"Researcher","foaf:name":[{"@value":"Scott K. Powers"}],"jpcoar:affiliationName":[{"@value":"Department of Applied Physiology and Kinesiology University of Florida  Gainesville FL 32608 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319950324736","@type":"Researcher","foaf:name":[{"@value":"Zsolt Radak"}],"jpcoar:affiliationName":[{"@value":"Research Institute of Sport Science University of Physical Education  Budapest Hungary"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319950324738","@type":"Researcher","foaf:name":[{"@value":"Li Li Ji"}],"jpcoar:affiliationName":[{"@value":"School of Kinesiology University of Minnesota  111 Cooke Hall, 1900 University Avenue Minneapolis MN 55455 USA"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00223751"},{"@type":"EISSN","@value":"14697793"}],"prism:publicationName":[{"@value":"The Journal of Physiology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2016-02-19","prism:volume":"594","prism:number":"18","prism:startingPage":"5081","prism:endingPage":"5092"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1113%2FJP270646"},{"@id":"https://physoc.onlinelibrary.wiley.com/doi/pdf/10.1113/JP270646"}],"createdAt":"2016-02-20","modifiedAt":"2023-09-29","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360294643860343424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Role of Nrf2 in Skeletal Muscle on Exercise Capacity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567687096064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Exercise-induced oxidative stress: Friend or foe?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567848319232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cessation of electrically-induced muscle contraction activates autophagy in cultured myotubes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593786128640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Protein Composition of Circulating Extracellular Vesicles Immediately Changed by Particular Short Time of High-Intensity Interval Training Exercise"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694370380323328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Association between redox state of human serum albumin and exercise capacity in older women: A cross‐sectional study"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679307845888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Changes in oxidative stress severity and antioxidant potential during muscle          atrophy and reloading in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1390587903890803200","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"一過性の運動に伴う骨格筋疲労に対する酸化ストレスの寄与"},{"@language":"en","@value":"Contribution of oxidative stress to skeletal muscle fatigue following acute exercise"},{"@language":"ja-Kana","@value":"イッカセイ ノ ウンドウ ニ トモナウ コッカクキン ヒロウ ニ タイスル サンカ ストレス ノ キヨ"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1113/jp270646"},{"@type":"CROSSREF","@value":"10.3390/antiox10111712_references_DOI_Qv9ezykBWtpMFXlMs8CZhGvjoC0"},{"@type":"CROSSREF","@value":"10.7600/jspfsm.74.283_references_DOI_Qv9ezykBWtpMFXlMs8CZhGvjoC0"},{"@type":"CROSSREF","@value":"10.1016/j.jshs.2020.04.001_references_DOI_Qv9ezykBWtpMFXlMs8CZhGvjoC0"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2020.09.009_references_DOI_Qv9ezykBWtpMFXlMs8CZhGvjoC0"},{"@type":"CROSSREF","@value":"10.3389/fphys.2021.693007_references_DOI_GX4LExJNdTAIXK3PicthzqGDleX"},{"@type":"CROSSREF","@value":"10.1111/ggi.13849_references_DOI_Qv9ezykBWtpMFXlMs8CZhGvjoC0"},{"@type":"CROSSREF","@value":"10.1589/jpts.30.42_references_DOI_Qv9ezykBWtpMFXlMs8CZhGvjoC0"}]}