{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319952216320.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.1094359"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.1094359"}},{"identifier":{"@type":"PMID","@value":"15155940"}},{"identifier":{"@type":"NAID","@value":"80016674563"}}],"dc:title":[{"@value":"Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n                    Apoptotic cells expose phosphatidylserine and are swiftly engulfed by macrophages. Milk fat globule epidermal growth factor (EGF) factor 8 (MFG-E8) is a protein that binds to apoptotic cells by recognizing phosphatidylserine and that enhances the engulfment of apoptotic cells by macrophages. We report that tingible body macrophages in the germinal centers of the spleen and lymph nodes strongly express MFG-E8. Many apoptotic lymphocytes were found on the\n                    <jats:italic>MFG-E8</jats:italic>\n                    <jats:sup>–/–</jats:sup>\n                    tingible body macrophages, but they were not efficiently engulfed. The\n                    <jats:italic>MFG-E8</jats:italic>\n                    <jats:sup>–/–</jats:sup>\n                    mice developed splenomegaly, with the formation of numerous germinal centers, and suffered from glomerulonephritis as a result of autoantibody production. These data demonstrate that MFG-E8 has a critical role in removing apoptotic B cells in the germinal centers and that its failure can lead to autoimmune diseases.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326209494656","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40403191"},{"@type":"NRID","@value":"1000040403191"},{"@type":"NRID","@value":"9000415085101"},{"@type":"NRID","@value":"9000238458577"},{"@type":"NRID","@value":"9000356480902"},{"@type":"NRID","@value":"9000342441315"},{"@type":"NRID","@value":"9000412284630"},{"@type":"NRID","@value":"9000402791750"},{"@type":"NRID","@value":"9000336379005"},{"@type":"NRID","@value":"9000403438836"},{"@type":"NRID","@value":"9000399181109"},{"@type":"NRID","@value":"9000397687061"},{"@type":"NRID","@value":"9000010203365"},{"@type":"NRID","@value":"9000406211305"},{"@type":"NRID","@value":"9000375852337"},{"@type":"NRID","@value":"9000301749832"},{"@type":"NRID","@value":"9000411989384"},{"@type":"NRID","@value":"9000264271627"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0121168"}],"foaf:name":[{"@value":"Rikinari Hanayama"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Department of Pathology, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Department of Cell Biology and Neuroscience, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Laboratory for Innate Cellular Immunity, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan."},{"@value":"Laboratory of Genetics, Integrated Biology Laboratories, Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276180467584","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00294059"},{"@type":"NRID","@value":"1000000294059"},{"@type":"NRID","@value":"9000240165423"},{"@type":"NRID","@value":"9000356533073"},{"@type":"NRID","@value":"9000018390174"},{"@type":"NRID","@value":"9000018282383"},{"@type":"NRID","@value":"9000404514532"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0208997"}],"foaf:name":[{"@value":"Masato Tanaka"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Department of Pathology, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Department of Cell Biology and Neuroscience, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Laboratory for Innate Cellular Immunity, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan."},{"@value":"Laboratory of Genetics, Integrated Biology Laboratories, Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319952216320","@type":"Researcher","foaf:name":[{"@value":"Kay Miyasaka"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Department of Pathology, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Department of Cell Biology and Neuroscience, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Laboratory for Innate Cellular Immunity, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan."},{"@value":"Laboratory of Genetics, Integrated Biology Laboratories, Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319952216449","@type":"Researcher","foaf:name":[{"@value":"Katsuyuki Aozasa"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Department of Pathology, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Department of Cell Biology and Neuroscience, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Laboratory for Innate Cellular Immunity, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan."},{"@value":"Laboratory of Genetics, Integrated Biology Laboratories, Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319952216322","@type":"Researcher","foaf:name":[{"@value":"Masato Koike"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Department of Pathology, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Department of Cell Biology and Neuroscience, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Laboratory for Innate Cellular Immunity, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan."},{"@value":"Laboratory of Genetics, Integrated Biology Laboratories, Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319952216321","@type":"Researcher","foaf:name":[{"@value":"Yasuo Uchiyama"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Department of Pathology, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Department of Cell Biology and Neuroscience, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Laboratory for Innate Cellular Immunity, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan."},{"@value":"Laboratory of Genetics, Integrated Biology Laboratories, Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319952216323","@type":"Researcher","foaf:name":[{"@value":"Shigekazu Nagata"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Department of Pathology, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Department of Cell Biology and Neuroscience, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan."},{"@value":"Laboratory for Innate Cellular Immunity, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan."},{"@value":"Laboratory of Genetics, Integrated Biology Laboratories, Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/00368075"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00368075"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"2004-05-21","prism:volume":"304","prism:number":"5674","prism:startingPage":"1147","prism:endingPage":"1150"},"reviewed":"false","url":[{"@id":"https://www.science.org/doi/pdf/10.1126/science.1094359"}],"createdAt":"2004-05-20","modifiedAt":"2024-01-09","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=T-Lymphocytes","dc:title":"T-Lymphocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Antigens,%20Differentiation,%20Myelomonocytic","dc:title":"Antigens, Differentiation, Myelomonocytic"},{"@id":"https://cir.nii.ac.jp/all?q=Apoptosis","dc:title":"Apoptosis"},{"@id":"https://cir.nii.ac.jp/all?q=Phosphatidylserines","dc:title":"Phosphatidylserines"},{"@id":"https://cir.nii.ac.jp/all?q=Autoimmune%20Diseases","dc:title":"Autoimmune Diseases"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Glomerulonephritis","dc:title":"Glomerulonephritis"},{"@id":"https://cir.nii.ac.jp/all?q=Phagocytosis","dc:title":"Phagocytosis"},{"@id":"https://cir.nii.ac.jp/all?q=Antigens,%20CD","dc:title":"Antigens, CD"},{"@id":"https://cir.nii.ac.jp/all?q=In%20Situ%20Nick-End%20Labeling","dc:title":"In Situ Nick-End Labeling"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Autoantibodies","dc:title":"Autoantibodies"},{"@id":"https://cir.nii.ac.jp/all?q=B-Lymphocytes","dc:title":"B-Lymphocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Membrane%20Glycoproteins","dc:title":"Membrane Glycoproteins"},{"@id":"https://cir.nii.ac.jp/all?q=Macrophages","dc:title":"Macrophages"},{"@id":"https://cir.nii.ac.jp/all?q=Macrophage%20Activation","dc:title":"Macrophage 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