{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319964852352.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/jcm8070924"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/2077-0383/8/7/924/pdf"}}],"dc:title":[{"@value":"New Cardiovascular Biomarkers in Ischemic Heart Disease—GDF-15, A Probable Predictor for Ejection Fraction"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Background: Various biomarkers have been associated with coronary artery disease (CAD) and ischemic heart failure. The aim of this study was to investigate the correlation of serum levels of soluble urokinase-type plasminogen activator receptor (suPAR), growth differentiation factor 15 (GDF-15), heart-type fatty acid-binding protein (H-FABP), and soluble suppression of tumorigenicity 2 (sST2) with left ventricular ejection fraction (EF) in CAD patients and controls. Methods and Results: CAD patients were divided into three groups according to their EF as measured by the biplane Simpson method (53–84%, 31–52%, ≤30%). Overall, 361 subjects were analyzed. In total, 155 CAD patients had an EF of 53–84%, 71 patients had an EF of 31–52%, and 23 patients had an EF of ≤30% as compared to 112 healthy controls (age 51.3 ± 9.0 years, 44.6% female). Mean ages according to EF were 62.1 ± 10.9, 65.2 ± 10.1, and 66.6 ± 8.2 years, respectively, with females representing 29.0, 29.6, and 13.0%. suPAR, GDF-15, H-FABP, and sST2 values were significantly higher in CAD patients and showed an exponential increase with decreasing EF. In a multiple logistic regression model, GDF-15 (p = 0.009), and NT-brain natriuretic peptide (p = 0.003) were independently associated with EF. Conclusion: Biomarkers such as suPAR, GDF-15, H-FABP, and sST2 are increased in CAD patients, especially in highly impaired EF. Besides NT-proBNP as a well-known marker for risk prediction, GDF-15 may be an additional tool for diagnosis and clinical follow-up.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319964852358","@type":"Researcher","foaf:name":[{"@value":"Daniel Dalos"}],"jpcoar:affiliationName":[{"@value":"Division of Cardiology, Medical University of Vienna, 1090 Vienna, Austria"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319964852356","@type":"Researcher","foaf:name":[{"@value":"Georg Spinka"}],"jpcoar:affiliationName":[{"@value":"Division of Cardiology, Medical University of Vienna, 1090 Vienna, Austria"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319964852359","@type":"Researcher","foaf:name":[{"@value":"Matthias Schneider"}],"jpcoar:affiliationName":[{"@value":"Division of Cardiology, Medical University of Vienna, 1090 Vienna, Austria"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319964852360","@type":"Researcher","foaf:name":[{"@value":"Bernhard Wernly"}],"jpcoar:affiliationName":[{"@value":"Division of Cardiology, Paracelsus Medical University of Salzburg, 5020 Salzburg, Austria"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319964852352","@type":"Researcher","foaf:name":[{"@value":"Vera Paar"}],"jpcoar:affiliationName":[{"@value":"Division of Cardiology, Paracelsus Medical University of Salzburg, 5020 Salzburg, Austria"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319964852355","@type":"Researcher","foaf:name":[{"@value":"Uta Hoppe"}],"jpcoar:affiliationName":[{"@value":"Division of Cardiology, Paracelsus Medical University of Salzburg, 5020 Salzburg, Austria"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319964852357","@type":"Researcher","foaf:name":[{"@value":"Brigitte Litschauer"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacology, Medical University of Vienna, 1090 Vienna, Austria"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319964852354","@type":"Researcher","foaf:name":[{"@value":"Jeanette Strametz-Juranek"}],"jpcoar:affiliationName":[{"@value":"Division of Cardiology, Medical University of Vienna, 1090 Vienna, Austria"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319964852353","@type":"Researcher","foaf:name":[{"@value":"Michael Sponder"}],"jpcoar:affiliationName":[{"@value":"Division of Cardiology, Medical University of Vienna, 1090 Vienna, Austria"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20770383"}],"prism:publicationName":[{"@value":"Journal of Clinical Medicine"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2019-06-27","prism:volume":"8","prism:number":"7","prism:startingPage":"924"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.mdpi.com/2077-0383/8/7/924/pdf"}],"createdAt":"2019-06-27","modifiedAt":"2025-10-11","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050866901652784768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Soluble urokinase-type plasminogen activator receptor represents exercise tolerance and predicts adverse cardiac events in patients with heart failure"},{"@language":"ja-Kana","@value":"カヨウセイ ウロキナーゼ ガタ プラスミノーゲン カッセイカ インシ ジュヨウタイ ワ シンフゼン カンジャ ニオケル ウンドウタイヨウノウ オ シメシ テオリ ユウガイ シン イベント オ ヨソク スル"},{"@language":"ja","@value":"可溶性ウロキナーゼ型プラスミノーゲン活性化因子受容体は心不全患者における運動耐容能を示しており有害心イベントを予測する"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.3390/jcm8070924"},{"@type":"CROSSREF","@value":"10.1007/s00380-019-01538-3_references_DOI_EsHrQiOvmD43SBL3IblEQFkVEl0"}]}