{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319977159040.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1523/jneurosci.1002-05.2005"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1523/JNEUROSCI.1002-05.2005"}}],"dc:title":[{"@value":"Imaging Experimental Cerebral Malaria<i>In Vivo</i>: Significant Role of Ischemic Brain Edema"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The first<jats:italic>in vivo</jats:italic>magnetic resonance study of experimental cerebral malaria is presented. Cerebral involvement is a lethal complication of malaria. To explore the brain of susceptible mice infected with<jats:italic>Plasmodium berghei</jats:italic>ANKA, multimodal magnetic resonance techniques were applied (imaging, diffusion, perfusion, angiography, spectroscopy). They reveal vascular damage including blood-brain barrier disruption and hemorrhages attributable to inflammatory processes. We provide the first<jats:italic>in vivo</jats:italic>demonstration for blood-brain barrier breakdown in cerebral malaria. Major edema formation as well as reduced brain perfusion was detected and is accompanied by an ischemic metabolic profile with reduction of high-energy phosphates and elevated brain lactate. In addition, angiography supplies compelling evidence for major hemodynamics dysfunction. Actually, edema further worsens ischemia by compressing cerebral arteries, which subsequently leads to a collapse of the blood flow that ultimately represents the cause of death. These findings demonstrate the coexistence of inflammatory and ischemic lesions and prove the preponderant role of edema in the fatal outcome of experimental cerebral malaria. They improve our understanding of the pathogenesis of cerebral malaria and may provide the necessary noninvasive surrogate markers for quantitative monitoring of treatment.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380298344572632456","@type":"Researcher","foaf:name":[{"@value":"Marie-France Penet"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298344572632453","@type":"Researcher","foaf:name":[{"@value":"Angèle Viola"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298344572632451","@type":"Researcher","foaf:name":[{"@value":"Sylviane Confort-Gouny"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298344572632321","@type":"Researcher","foaf:name":[{"@value":"Yann Le Fur"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298344572632449","@type":"Researcher","foaf:name":[{"@value":"Guillaume Duhamel"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298344572632457","@type":"Researcher","foaf:name":[{"@value":"Frank Kober"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298344572632454","@type":"Researcher","foaf:name":[{"@value":"Danielle Ibarrola"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298344572632455","@type":"Researcher","foaf:name":[{"@value":"Marguerite Izquierdo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298344572632320","@type":"Researcher","foaf:name":[{"@value":"Nicolas Coltel"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298344572632450","@type":"Researcher","foaf:name":[{"@value":"Bouchra Gharib"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298344572632448","@type":"Researcher","foaf:name":[{"@value":"Georges E. Grau"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298344572632452","@type":"Researcher","foaf:name":[{"@value":"Patrick J. Cozzone"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02706474"},{"@type":"EISSN","@value":"15292401"}],"prism:publicationName":[{"@value":"The Journal of Neuroscience"}],"dc:publisher":[{"@value":"Society for Neuroscience"}],"prism:publicationDate":"2005-08-10","prism:volume":"25","prism:number":"32","prism:startingPage":"7352","prism:endingPage":"7358"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by-nc-sa/4.0/"],"url":[{"@id":"https://syndication.highwire.org/content/doi/10.1523/JNEUROSCI.1002-05.2005"}],"createdAt":"2005-08-10","modifiedAt":"2023-04-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360290617445203456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Blood–cerebrospinal fluid barrier: another site disrupted during experimental cerebral malaria caused by Plasmodium berghei ANKA"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658378982784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tissue-specific immunopathology during malaria infection"}]},{"@id":"https://cir.nii.ac.jp/crid/2050870367067416832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Upper gastrointestinal pathophysiology due to mouse malaria Plasmodium berghei ANKA infection"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1523/jneurosci.1002-05.2005"},{"@type":"CROSSREF","@value":"10.1016/j.ijpara.2020.07.007_references_DOI_8b41K5u4oFt2jhlwupdGhDYYr8I"},{"@type":"CROSSREF","@value":"10.1038/nri.2017.138_references_DOI_8b41K5u4oFt2jhlwupdGhDYYr8I"},{"@type":"CROSSREF","@value":"10.1186/s41182-019-0146-9_references_DOI_8b41K5u4oFt2jhlwupdGhDYYr8I"}]}