{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319980353408.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1161/01.atv.0000129537.72553.73"}},{"identifier":{"@type":"URI","@value":"https://www.ahajournals.org/doi/full/10.1161/01.ATV.0000129537.72553.73"}}],"dc:title":[{"@value":"Deep Vein Thrombosis Resolution Is Modulated by Monocyte CXCR2-Mediated Activity in a Mouse Model"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p><jats:bold><jats:italic>Objective—</jats:italic></jats:bold>To determine the role of CXCR2, the receptor for cysteine-X-cysteine (CXC) chemokines, and its primary effector cell, the neutrophil (PMN), on deep venous thrombosis (DVT) resolution.</jats:p><jats:p><jats:bold><jats:italic>Methods and Results—</jats:italic></jats:bold>DVT in BALB/c, anti-CXCR2 antibody-treated, and BALB/c CXCR2<jats:sup>−/−</jats:sup>mice were created by infrarenal inferior vena cava (IVC) ligation and the thrombus harvested at various time points over 21 days. The CXCR2<jats:sup>−/−</jats:sup>mice had significantly larger thrombi at early time points (days 2 to 8), and significantly decreased intrathrombus PMNs, monocytes, and neovascularization as compared with controls. Thrombus KC/CXCL1 was significantly higher at 2 days in CXCR2<jats:sup>−/−</jats:sup>thrombi as measured by enzyme-linked immunosorbent assay. Fibrin content was significantly higher, with less uPA gene expression at 4 days in CXCR2<jats:sup>−/−</jats:sup>thrombi. Late fibrotic maturation of the thrombus was delayed in the CXCR2<jats:sup>−/−</jats:sup>mice, with significantly decreased 8 day MMP-2 activity, whereas MMP-9 activity was elevated as compared with controls. Similar impairment in DVT resolution was found at 8 days with anti-CXCR2 inhibition. However, systemic neutropenia, unlike CXCR2 deletion, did not increase the thrombus size as compared with controls.</jats:p><jats:p><jats:bold><jats:italic>Conclusions—</jats:italic></jats:bold>Normal DVT resolution involves CXCR2-mediated neovascularization, collagen turnover, and fibrinolysis, and it is probably primarily monocyte-dependent.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319980353412","@type":"Researcher","foaf:name":[{"@value":"Peter K. Henke"}],"jpcoar:affiliationName":[{"@value":"From the Section of Vascular Surgery, Jobst Vascular Research Laboratory, Department of Surgery (P.K.H., A.V., S.D., C.B.D., J.E., P.S., P.T., G.R.U., T.W.W.), the Division of Pulmonary Medicine, Department of Medicine (D.A.A.), and the Department of Pathology (S.L.K.), University of Michigan Medical School, Ann Arbor, Mich."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319980353411","@type":"Researcher","foaf:name":[{"@value":"Andrea Varga"}],"jpcoar:affiliationName":[{"@value":"From the Section of Vascular Surgery, Jobst Vascular Research Laboratory, Department of Surgery (P.K.H., A.V., S.D., C.B.D., J.E., P.S., P.T., G.R.U., T.W.W.), the Division of Pulmonary Medicine, Department of Medicine (D.A.A.), and the Department of Pathology (S.L.K.), University of Michigan Medical School, Ann Arbor, Mich."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319980353416","@type":"Researcher","foaf:name":[{"@value":"Sumit De"}],"jpcoar:affiliationName":[{"@value":"From the Section of Vascular Surgery, Jobst Vascular Research Laboratory, Department of Surgery (P.K.H., A.V., S.D., C.B.D., J.E., P.S., P.T., G.R.U., T.W.W.), the Division of Pulmonary Medicine, Department of Medicine (D.A.A.), and the Department of Pathology (S.L.K.), University of Michigan Medical School, Ann Arbor, Mich."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319980353414","@type":"Researcher","foaf:name":[{"@value":"C. Barry Deatrick"}],"jpcoar:affiliationName":[{"@value":"From the Section of Vascular Surgery, Jobst Vascular Research Laboratory, Department of Surgery (P.K.H., A.V., S.D., C.B.D., J.E., P.S., P.T., G.R.U., T.W.W.), the Division of Pulmonary Medicine, Department of Medicine (D.A.A.), and the Department of Pathology (S.L.K.), University of Michigan Medical School, Ann Arbor, Mich."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319980353408","@type":"Researcher","foaf:name":[{"@value":"Jonathon Eliason"}],"jpcoar:affiliationName":[{"@value":"From the Section of Vascular Surgery, Jobst Vascular Research Laboratory, Department of Surgery (P.K.H., A.V., S.D., C.B.D., J.E., P.S., P.T., G.R.U., T.W.W.), the Division of Pulmonary Medicine, Department of Medicine (D.A.A.), and the Department of Pathology (S.L.K.), University of Michigan Medical School, Ann Arbor, Mich."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319980353410","@type":"Researcher","foaf:name":[{"@value":"Douglas A. Arenberg"}],"jpcoar:affiliationName":[{"@value":"From the Section of Vascular Surgery, Jobst Vascular Research Laboratory, Department of Surgery (P.K.H., A.V., S.D., C.B.D., J.E., P.S., P.T., G.R.U., T.W.W.), the Division of Pulmonary Medicine, Department of Medicine (D.A.A.), and the Department of Pathology (S.L.K.), University of Michigan Medical School, Ann Arbor, Mich."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319980353415","@type":"Researcher","foaf:name":[{"@value":"Pasu Sukheepod"}],"jpcoar:affiliationName":[{"@value":"From the Section of Vascular Surgery, Jobst Vascular Research Laboratory, Department of Surgery (P.K.H., A.V., S.D., C.B.D., J.E., P.S., P.T., G.R.U., T.W.W.), the Division of Pulmonary Medicine, Department of Medicine (D.A.A.), and the Department of Pathology (S.L.K.), University of Michigan Medical School, Ann Arbor, Mich."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319980353417","@type":"Researcher","foaf:name":[{"@value":"Porama Thanaporn"}],"jpcoar:affiliationName":[{"@value":"From the Section of Vascular Surgery, Jobst Vascular Research Laboratory, Department of Surgery (P.K.H., A.V., S.D., C.B.D., J.E., P.S., P.T., G.R.U., T.W.W.), the Division of Pulmonary Medicine, Department of Medicine (D.A.A.), and the Department of Pathology (S.L.K.), University of Michigan Medical School, Ann Arbor, Mich."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319980353409","@type":"Researcher","foaf:name":[{"@value":"Steven L. Kunkel"}],"jpcoar:affiliationName":[{"@value":"From the Section of Vascular Surgery, Jobst Vascular Research Laboratory, Department of Surgery (P.K.H., A.V., S.D., C.B.D., J.E., P.S., P.T., G.R.U., T.W.W.), the Division of Pulmonary Medicine, Department of Medicine (D.A.A.), and the Department of Pathology (S.L.K.), University of Michigan Medical School, Ann Arbor, Mich."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319980353418","@type":"Researcher","foaf:name":[{"@value":"Gilbert R. Upchurch"}],"jpcoar:affiliationName":[{"@value":"From the Section of Vascular Surgery, Jobst Vascular Research Laboratory, Department of Surgery (P.K.H., A.V., S.D., C.B.D., J.E., P.S., P.T., G.R.U., T.W.W.), the Division of Pulmonary Medicine, Department of Medicine (D.A.A.), and the Department of Pathology (S.L.K.), University of Michigan Medical School, Ann Arbor, Mich."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319980353413","@type":"Researcher","foaf:name":[{"@value":"Thomas W. Wakefield"}],"jpcoar:affiliationName":[{"@value":"From the Section of Vascular Surgery, Jobst Vascular Research Laboratory, Department of Surgery (P.K.H., A.V., S.D., C.B.D., J.E., P.S., P.T., G.R.U., T.W.W.), the Division of Pulmonary Medicine, Department of Medicine (D.A.A.), and the Department of Pathology (S.L.K.), University of Michigan Medical School, Ann Arbor, Mich."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10795642"},{"@type":"EISSN","@value":"15244636"}],"prism:publicationName":[{"@value":"Arteriosclerosis, Thrombosis, and Vascular Biology"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2004-06","prism:volume":"24","prism:number":"6","prism:startingPage":"1130","prism:endingPage":"1137"},"reviewed":"false","url":[{"@id":"https://www.ahajournals.org/doi/full/10.1161/01.ATV.0000129537.72553.73"}],"createdAt":"2004-04-27","modifiedAt":"2023-04-28","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002215931753856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Time-dependent organic changes of intravenous thrombi in stasis-induced deep vein thrombosis model and its application to thrombus age determination"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690286429568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Time-dependent appearance of intrathrombus neutrophils and macrophages in a stasis-induced deep vein thrombosis model and its application to thrombus age determination"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711408071040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Contribution of the TNF-α (Tumor Necrosis Factor-α)–TNF-Rp55 (Tumor Necrosis Factor Receptor p55) Axis in the Resolution of Venous Thrombus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588381046552448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Usefulness of serial in vivo imaging to directly assess the role of inflammation in thrombus resolution and organization"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643736011008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Absence of IFN-γ accelerates thrombus resolution through enhanced MMP-9 and VEGF expression in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361413119135161472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Crucial Involvement of IL-6 in Thrombus Resolution in Mice via Macrophage Recruitment and the Induction of Proteolytic Enzymes"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1161/01.atv.0000129537.72553.73"},{"@type":"CROSSREF","@value":"10.1016/j.forsciint.2009.12.008_references_DOI_CAhUp6egcB7s4SJhQqahxRsCoM5"},{"@type":"CROSSREF","@value":"10.1007/s00414-009-0324-0_references_DOI_CAhUp6egcB7s4SJhQqahxRsCoM5"},{"@type":"CROSSREF","@value":"10.1161/atvbaha.118.311194_references_DOI_CAhUp6egcB7s4SJhQqahxRsCoM5"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2025.151293_references_DOI_CAhUp6egcB7s4SJhQqahxRsCoM5"},{"@type":"CROSSREF","@value":"10.1172/jci40782_references_DOI_CAhUp6egcB7s4SJhQqahxRsCoM5"},{"@type":"CROSSREF","@value":"10.3389/fimmu.2019.03150_references_DOI_CAhUp6egcB7s4SJhQqahxRsCoM5"}]}