{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670319983504384.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1177/0091270006291035"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1177%2F0091270006291035"}},{"identifier":{"@type":"URI","@value":"https://accp1.onlinelibrary.wiley.com/doi/pdf/10.1177/0091270006291035"}}],"dc:title":[{"@value":"Population Pharmacokinetic Analysis and Dosing Regimen Optimization of Meropenem in Adult Patients"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The objectives of this study were to develop a meropenem population pharmacokinetic model using patient data and use it to explore alternative dosage regimens that could optimize the currently used dosing regimen to achieve higher likelihood of pharmacodynamic exposure against pathogenic bacteria. We gathered concentration data from 79 patients (ages 18–93 years) who received meropenem 0.5, 1, or 2 g over 0.5‐ or 3‐hour infusion every 8 hours. Meropenem population pharmacokinetic analysis was performed using the NONMEM program. A 2‐compartment model fit the data best. Creatinine clearance, age, and body weight were the most significant covariates to affect meropenem pharmacokinetics. Monte Carlo simulation was applied to mimic the concentration‐time profiles while 1 g meropenem was administrated via infusion over 0.5, 1, 2, and 3 hours. The 3‐hour prolonged infusion improved the likelihood of obtaining both bacteriostatic and bactericidal exposures most notably at the current susceptibility breakpoints.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670319983504256","@type":"Researcher","foaf:name":[{"@value":"Chonghua Li"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319983504385","@type":"Researcher","foaf:name":[{"@value":"Joseph L. Kuti"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319983504384","@type":"Researcher","foaf:name":[{"@value":"Charles H. Nightingale"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670319983504257","@type":"Researcher","foaf:name":[{"@value":"David P. Nicolau"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00912700"},{"@type":"EISSN","@value":"15524604"}],"prism:publicationName":[{"@value":"The Journal of Clinical Pharmacology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2006-10","prism:volume":"46","prism:number":"10","prism:startingPage":"1171","prism:endingPage":"1178"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1177%2F0091270006291035"},{"@id":"https://accp1.onlinelibrary.wiley.com/doi/pdf/10.1177/0091270006291035"}],"createdAt":"2006-09-20","modifiedAt":"2023-10-12","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360294643815351040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Ceftolozane/tazobactam versus meropenem in patients with ventilated hospital-acquired bacterial pneumonia: subset analysis of the ASPECT-NP randomized, controlled phase 3 trial"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656229892608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Optimal treatment schedule of meropenem for adult patients with febrile neutropenia based on pharmacokinetic–pharmacodynamic analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205178284544","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Optimal Dosage Regimen of Meropenem for Pediatric Patients Based on Pharmacokinetic/Pharmacodynamic Considerations"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679753279872","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Optimal Usage of Meropenem Based on Recommended Regimen Derived from Monte Carlo Simulation"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1177/0091270006291035"},{"@type":"CROSSREF","@value":"10.5649/jjphcs.34.764_references_DOI_HeZca9LnU3gzM85TWAMcXXTN9NJ"},{"@type":"CROSSREF","@value":"10.2133/dmpk.dmpk-11-rg-027_references_DOI_HeZca9LnU3gzM85TWAMcXXTN9NJ"},{"@type":"CROSSREF","@value":"10.1186/s13054-021-03694-3_references_DOI_HeZca9LnU3gzM85TWAMcXXTN9NJ"},{"@type":"CROSSREF","@value":"10.1007/s10156-011-0271-9_references_DOI_HeZca9LnU3gzM85TWAMcXXTN9NJ"}]}