{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320109267200.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/s0304-3835(99)00132-9"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0304383599001329?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0304383599001329?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"10503911"}}],"dc:title":[{"@value":"Mutagenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the new gptΔ transgenic mouse"}],"description":[{"notation":[{"@value":"Gender differences and organ specificity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mutagenesis were examined with the new gptdelta transgenic mouse (T. Nohmi, M. Katoh, H. Suzuki, M. Matsui, M. Yamada, M. Watanabe, M. Suzuki, N. Horiya, O. Ueda, T. Shibuya, H. Ikeda, T. Sofuni, A new transgenic mouse mutagenesis test system using Spi-and 6-thioguanine selections (Environ. Mol. Mutagen. 28 (1996) 465-470). In this mouse model, two distinct selections are employed to efficiently detect different types of mutations, i.e 6-thioguanine (6-TG) selection for point mutations and Spi-selection for deletions, respectively. In both selections, the highest mutant frequencies were observed in colon, followed by in spleen and liver. No increases in mutations were observed in testis, brain and bone marrow in PhIP-treated male mice. No significant differences in 6-TG and Spi- mutant frequencies were observed in colon and liver between male and female treated mice. The correlation between PhIP-induced mutagenesis and carcinogenesis in colon is discussed."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320109267200","@type":"Researcher","foaf:name":[{"@value":"Kenichi Masumura"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320109267209","@type":"Researcher","foaf:name":[{"@value":"Keiko Matsui"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320109267206","@type":"Researcher","foaf:name":[{"@value":"Masami Yamada"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320109267211","@type":"Researcher","foaf:name":[{"@value":"Mieko Horiguchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320109267204","@type":"Researcher","foaf:name":[{"@value":"Kaori Ishida"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320109267072","@type":"Researcher","foaf:name":[{"@value":"Masahiko Watanabe"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320109267208","@type":"Researcher","foaf:name":[{"@value":"Otoya Ueda"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320109267205","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320109267203","@type":"Researcher","foaf:name":[{"@value":"Yuhsuke Kanke"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320109267210","@type":"Researcher","foaf:name":[{"@value":"Kenneth R. Tindall"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320109267202","@type":"Researcher","foaf:name":[{"@value":"Keiji Wakabayashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320109267207","@type":"Researcher","foaf:name":[{"@value":"Toshio Sofuni"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320109267201","@type":"Researcher","foaf:name":[{"@value":"Takehiko Nohmi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03043835"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/03043835"}],"prism:publicationName":[{"@value":"Cancer Letters"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"1999-09","prism:volume":"143","prism:number":"2","prism:startingPage":"241","prism:endingPage":"244"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0304383599001329?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0304383599001329?httpAccept=text/plain"}],"createdAt":"2002-07-25","modifiedAt":"2019-04-19","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Colon","dc:title":"Colon"},{"@id":"https://cir.nii.ac.jp/all?q=Escherichia%20coli%20Proteins","dc:title":"Escherichia coli Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Imidazoles","dc:title":"Imidazoles"},{"@id":"https://cir.nii.ac.jp/all?q=Proteins","dc:title":"Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Transgenic","dc:title":"Mice, Transgenic"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Bacterial%20Proteins","dc:title":"Bacterial Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Liver","dc:title":"Liver"},{"@id":"https://cir.nii.ac.jp/all?q=Mutation","dc:title":"Mutation"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Pentosyltransferases","dc:title":"Pentosyltransferases"},{"@id":"https://cir.nii.ac.jp/all?q=Spleen","dc:title":"Spleen"},{"@id":"https://cir.nii.ac.jp/all?q=Mutagens","dc:title":"Mutagens"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001204498854784","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Spontaneous Mutagenesis in Rodents: Spontaneous Gene Mutations Identified by Neutral Reporter Genes in gpt Delta Transgenic Mice and Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205257108736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Evaluation of the in vivo Mutagenicity of Nickel Subsulfide in the Lung of F344 gpt delta Transgenic Rats Exposed by Intratracheal Instillation: A Collaborative Study for the gpt delta Transgenic Rat Mutation Assay"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205257139584","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Novel DNA Polymerases and Novel Genotoxicity Assays"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205257779584","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"In Vivo Mutagenesis Caused by Diesel Exhaust in the Testis of gpt delta Transgenic Mice"},{"@value":"In vivo mutagenesis caused by diesel exhaust in the testis of gpt delta mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205257903872","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Spontaneous and Induced gpt and Spi- Mutant Frequencies in gpt delta Transgenic Rodents"},{"@value":"Spontaneous and Induced gpt and Spi− Mutant Frequencies in gpt delta Transgenic Rodents"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205510792704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Past, Present and Future Directions of <i>gpt</i> delta Rodent Gene Mutation Assays"},{"@value":"Past, present and future directions of gpt delta rodent gene mutation assays"}]},{"@id":"https://cir.nii.ac.jp/crid/2050307416984348288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evaluation of in vivo mutagenesis for assessing the health risk of air pollutants"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/s0304-3835(99)00132-9"},{"@type":"OPENAIRE","@value":"doi_dedup___::6ce8d65dff82f270ddc0f3d415bd2dc6"},{"@type":"CROSSREF","@value":"10.3123/jemsge.31.105_references_DOI_D8QA923JJTAo2ywgkbghlzhPIGQ"},{"@type":"CROSSREF","@value":"10.3123/jemsge.31.1_references_DOI_D8QA923JJTAo2ywgkbghlzhPIGQ"},{"@type":"CROSSREF","@value":"10.3123/jemsge.34.34_references_DOI_D8QA923JJTAo2ywgkbghlzhPIGQ"},{"@type":"CROSSREF","@value":"10.1186/s41021-016-0064-6_references_DOI_D8QA923JJTAo2ywgkbghlzhPIGQ"},{"@type":"CROSSREF","@value":"10.1248/jhs.55.40_references_DOI_D8QA923JJTAo2ywgkbghlzhPIGQ"},{"@type":"CROSSREF","@value":"10.3123/jemsge.29.75_references_DOI_D8QA923JJTAo2ywgkbghlzhPIGQ"},{"@type":"CROSSREF","@value":"10.14252/foodsafetyfscj.2015024_references_DOI_D8QA923JJTAo2ywgkbghlzhPIGQ"}]}