{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320143168384.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1242/dev.127.2.255"}},{"identifier":{"@type":"URI","@value":"https://journals.biologists.com/dev/article-pdf/127/2/255/3129991/develop_127_2_255.pdf"}}],"dc:title":[{"@value":"The fate of cells in the tailbud of <i>Xenopus laevis</i>"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>ABSTRACT</jats:title>\n               <jats:p>The vertebrate tailbud and trunk form very similar tissues. It has been a controversial question for decades whether cell determination in the developing tail proceeds as part of early axial development or whether it proceeds by a different mechanism. To examine this question more closely, we have used photoactivation of fluorescence to mark small neighborhoods of cells in the developing tailbud of Xenopus laevis. We show that, in one region of the tailbud, very small groups of adjacent cells can contribute progeny to the neural tube, notochord and somitic muscle, as well as other identified cell types within a single embryo. Groups averaging three adjacent cells at a later stage can contribute progeny with a similar distribution. Our data suggest that the tailbud contains multipotent cells that make very late germ-layer decisions.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380861295030923904","@type":"Researcher","foaf:name":[{"@value":"Robert L. Davis"}],"jpcoar:affiliationName":[{"@value":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861295030923905","@type":"Researcher","foaf:name":[{"@value":"Marc W. Kirschner"}],"jpcoar:affiliationName":[{"@value":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09501991"},{"@type":"EISSN","@value":"14779129"}],"prism:publicationName":[{"@value":"Development"}],"dc:publisher":[{"@value":"The Company of Biologists"}],"prism:publicationDate":"2000-01-15","prism:volume":"127","prism:number":"2","prism:startingPage":"255","prism:endingPage":"267"},"reviewed":"false","url":[{"@id":"https://journals.biologists.com/dev/article-pdf/127/2/255/3129991/develop_127_2_255.pdf"}],"createdAt":"2021-04-26","modifiedAt":"2023-09-05","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004232557126784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Three-dimensional anatomy of the Ciona intestinalis tailbud embryo at single-cell resolution"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708506244864","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Insulin-like factor regulates neural induction through an IGF1 receptor-independent mechanism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298755628661760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Understanding axial progenitor biology <i>in vivo</i> and <i>in vitro</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1520009409097485312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dual origin of melanocytes defined by Sox1 expression and their region-specific distribution in mammalian skin"}]},{"@id":"https://cir.nii.ac.jp/crid/1522825130472375040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"TRIQK, a novel family of small proteins localized to the endoplasmic reticulum membrane, is conserved across vertebrates"},{"@language":"ja-Kana","@value":"TRIQK a novel family of small proteins localized to the endoplasmic reticulum membrane is conserved across vertebrates"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1242/dev.127.2.255"},{"@type":"CROSSREF","@value":"10.1242/dev.180612_references_DOI_28CX7Bv1dYsXdj7P5DWIq7KtmWh"},{"@type":"CROSSREF","@value":"10.1016/j.ydbio.2012.09.007_references_DOI_28CX7Bv1dYsXdj7P5DWIq7KtmWh"},{"@type":"CROSSREF","@value":"10.1111/dgd.12034_references_DOI_28CX7Bv1dYsXdj7P5DWIq7KtmWh"},{"@type":"CROSSREF","@value":"10.1038/srep11603_references_DOI_28CX7Bv1dYsXdj7P5DWIq7KtmWh"},{"@type":"CROSSREF","@value":"10.2108/zsj.25.706_references_DOI_28CX7Bv1dYsXdj7P5DWIq7KtmWh"}]}