{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320146559104.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/0014-4800(84)90082-0"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:0014480084900820?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:0014480084900820?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"6705895"}}],"dc:title":[{"@value":"Differentiation of human pulmonary alveolar epithelial cells revealed by peroxisome changes in pulmonary proteinosis"}],"description":[{"notation":[{"@value":"Regenerating areas of human lungs in pulmonary fibrosis were observed electron microscopically, and peroxidatic activity of catalase in lung peroxisomes were demonstrated cytochemically. Proliferation of Type II cells was prominent there, and some of the cells extended their cytoplasms to cover the denuded basement membrane. Unusual intermediate cells between Type II and Type I cells were observed. The extension of cytoplasmic processes with new generation of pinocytotic vesicles strongly suggested a Type I cell profile. However, catalase-positive peroxisomes were found in these cells simultaneously. From these results it was concluded that Type I cells may originate from Type II cells in human lungs as they do in experimental animals."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320146558976","@type":"Researcher","foaf:name":[{"@value":"Keiichi Moriguchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320146558979","@type":"Researcher","foaf:name":[{"@value":"Nobuaki Higashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320146559105","@type":"Researcher","foaf:name":[{"@value":"Shunsuke Kitagawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320146558978","@type":"Researcher","foaf:name":[{"@value":"Keiichiro Takase"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320146559104","@type":"Researcher","foaf:name":[{"@value":"Nobuo Ohya"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320146558980","@type":"Researcher","foaf:name":[{"@value":"Tadashi Uyeda"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320146558977","@type":"Researcher","foaf:name":[{"@value":"Kei-Ichi Hirai"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00144800"}],"prism:publicationName":[{"@value":"Experimental and Molecular Pathology"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"1984-04","prism:volume":"40","prism:number":"2","prism:startingPage":"262","prism:endingPage":"270"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:0014480084900820?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:0014480084900820?httpAccept=text/plain"}],"createdAt":"2004-04-18","modifiedAt":"2025-09-05","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Cytoplasm","dc:title":"Cytoplasm"},{"@id":"https://cir.nii.ac.jp/all?q=Histocytochemistry","dc:title":"Histocytochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Differentiation","dc:title":"Cell Differentiation"},{"@id":"https://cir.nii.ac.jp/all?q=Pulmonary%20Alveolar%20Proteinosis","dc:title":"Pulmonary Alveolar Proteinosis"},{"@id":"https://cir.nii.ac.jp/all?q=Catalase","dc:title":"Catalase"},{"@id":"https://cir.nii.ac.jp/all?q=Microbodies","dc:title":"Microbodies"},{"@id":"https://cir.nii.ac.jp/all?q=Epithelium","dc:title":"Epithelium"},{"@id":"https://cir.nii.ac.jp/all?q=Mitochondria","dc:title":"Mitochondria"},{"@id":"https://cir.nii.ac.jp/all?q=Organoids","dc:title":"Organoids"},{"@id":"https://cir.nii.ac.jp/all?q=Pulmonary%20Alveoli","dc:title":"Pulmonary Alveoli"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Pinocytosis","dc:title":"Pinocytosis"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001338456661632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"nergy filtering transmission electron microscopy immunocytochemistry and antigen retrieval of surfaceEnergy filtering transmission electron microscopy immunocytochemistry and antigen retrieval of surface layer proteins from Tannerella forsythensis using microwave or autoclave heating with citraconic anhydride."},{"@language":"en","@value":"Energy filtering transmission electron microscopy immunocytochemistry and antigen retrieval of surface layer proteins from Tannerella forsythensis using microwave or autoclave heating with citraconic anhydride."}]},{"@id":"https://cir.nii.ac.jp/crid/1360004230172775552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Energy dispersive spectroscopy‐scanning transmission electron microscope observations of free radical production in human polymorphonuclear leukocytes phagocytosing non‐opsonized <i>Tannerella forsythia</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206322901376","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Immunocytochemical approach for surface layer proteins of freeze-substituted Tannerella forsythensis by energy-filtering transmission electron microscopy"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/0014-4800(84)90082-0"},{"@type":"OPENAIRE","@value":"doi_dedup___::fc1703a6903098db95fa7ab838c882e5"},{"@type":"CROSSREF","@value":"10.1002/jemt.22819_references_DOI_9eGGIO2Bq4VUsJHHHkhyr6c0gz5"},{"@type":"CROSSREF","@value":"10.3109/10520295.2012.687117_references_DOI_9eGGIO2Bq4VUsJHHHkhyr6c0gz5"},{"@type":"CROSSREF","@value":"10.2535/ofaj.85.67_references_DOI_9eGGIO2Bq4VUsJHHHkhyr6c0gz5"}]}