{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320157440512.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1186/1471-2156-8-39"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1186/1471-2156-8-39.pdf"}},{"identifier":{"@type":"PMID","@value":"17598916"}}],"dc:title":[{"@value":"New chemically induced skin tumour susceptibility loci identified in a mouse backcross between FVB and dominant resistant PWK"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>A variety of skin cancer susceptibility among mouse strains has allowed identification of genes responsible for skin cancer development. Fifteen<jats:italic>Skts</jats:italic>loci for skin tumour susceptibility have been mapped so far by using the two-stage skin carcinogenesis model [induced by 7.12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)]. A few responsible genes have been identified using wild-derived dominant resistant<jats:italic>Mus spretus</jats:italic>mice, and one has been confirmed as a low penetrance cancer susceptibility gene in a variety of human cancers.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>In the present study, we found that wild-derived PWK mice developed no tumour by treatment with the two-stage skin carcinogenesis protocol. This phenotype is dominant resistant when crossed with the highly susceptible strain FVB. By analyzing the F1 backcross generation between PWK and FVB, we found empirical evidence of significant linkage at the new loci<jats:italic>Skts-fp1</jats:italic>on chromosome 4 and suggestive linkage on chromosomes 1, 3, 11, 12 and 14 for skin tumour susceptibility.<jats:italic>Skts-fp1</jats:italic>includes the<jats:italic>Skts7</jats:italic>interval, which was previously mapped by a<jats:italic>Mus spretus</jats:italic>and NIH backcross. We also observed suggestive linkage on chromosomes 1 and 2 in the female population only, while suggestive linkage on chromosomes 14 and 15 only was observed in the male population. A significant genetic interaction was seen between markers of<jats:italic>D11Mit339</jats:italic>and<jats:italic>D16Mit14</jats:italic>.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Analysis of this new cross may facilitate the identification of genes responsible for mouse skin cancer susceptibility and may reveal their biological interactions.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320157440513","@type":"Researcher","foaf:name":[{"@value":"Kyoko Fujiwara"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320157440512","@type":"Researcher","foaf:name":[{"@value":"Jun Igarashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320157440515","@type":"Researcher","foaf:name":[{"@value":"Natsumi Irahara"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320157440514","@type":"Researcher","foaf:name":[{"@value":"Makoto Kimura"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320157440516","@type":"Researcher","foaf:name":[{"@value":"Hiroki Nagase"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14712156"}],"prism:publicationName":[{"@value":"BMC Genetics"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2007-06-28","prism:volume":"8","prism:number":"1","prism:startingPage":"39"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://link.springer.com/content/pdf/10.1186/1471-2156-8-39.pdf"}],"createdAt":"2007-06-29","modifiedAt":"2024-02-15","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Skin%20Neoplasms","dc:title":"Skin Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Genotype","dc:title":"Genotype"},{"@id":"https://cir.nii.ac.jp/all?q=Genetic%20Linkage","dc:title":"Genetic Linkage"},{"@id":"https://cir.nii.ac.jp/all?q=9,10-Dimethyl-1,2-benzanthracene","dc:title":"9,10-Dimethyl-1,2-benzanthracene"},{"@id":"https://cir.nii.ac.jp/all?q=Quantitative%20Trait%20Loci","dc:title":"Quantitative Trait Loci"},{"@id":"https://cir.nii.ac.jp/all?q=Drug%20Resistance","dc:title":"Drug Resistance"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20Strains","dc:title":"Mice, Inbred Strains"},{"@id":"https://cir.nii.ac.jp/all?q=QH426-470","dc:title":"QH426-470"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Genetics","dc:title":"Genetics"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Genetics(clinical)","dc:title":"Genetics(clinical)"},{"@id":"https://cir.nii.ac.jp/all?q=Genetic%20Predisposition%20to%20Disease","dc:title":"Genetic Predisposition to Disease"},{"@id":"https://cir.nii.ac.jp/all?q=Crosses,%20Genetic","dc:title":"Crosses, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Genes,%20Dominant","dc:title":"Genes, Dominant"},{"@id":"https://cir.nii.ac.jp/all?q=Papilloma","dc:title":"Papilloma"},{"@id":"https://cir.nii.ac.jp/all?q=Chromosome%20Mapping","dc:title":"Chromosome Mapping"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasms,%20Second%20Primary","dc:title":"Neoplasms, Second Primary"},{"@id":"https://cir.nii.ac.jp/all?q=Tetradecanoylphorbol%20Acetate","dc:title":"Tetradecanoylphorbol Acetate"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Research%20Article","dc:title":"Research Article"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285708457502720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The parathyroid hormone regulates skin tumour susceptibility in 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