{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320174611456.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1136/gut.42.4.497"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1136/gut.42.4.497"}}],"dc:title":[{"@value":"Controlled trial of antituberculous chemotherapy in Crohn’s disease: a five year follow up study"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n                    <jats:italic>Background</jats:italic>\n                    —It has been suggested that\n                    <jats:italic>Mycobacterium paratuberculosis</jats:italic>\n                    is the cause of Crohn’s disease. In a previous report the immediate effect of two years treatment with antituberculous chemotherapy showed no clinical benefit.\n                  </jats:p>\n                  <jats:p>\n                    <jats:italic>Aims</jats:italic>\n                    —To assess both the immediate and longer term effect of treatment on the disease.\n                  </jats:p>\n                  <jats:p>\n                    <jats:italic>Methods</jats:italic>\n                    —Patients were followed for five years from their date of entry to the study. One hundred and thirty patients entered the initial study, and of these 111 (81%) were followed regularly.\n                  </jats:p>\n                  <jats:p>\n                    <jats:italic>Results</jats:italic>\n                    —Overall, there was no evidence of consistent benefit or disadvantage from antituberculous chemotherapy in any of the assessments made, including the number of acute relapses, surgical episodes, hospital admissions, disease activity, blood tests, or medication required for Crohn’s disease during the follow up period.\n                  </jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion</jats:italic>\n                    —The absence of any benefit at the end of the initial two year trial period, and during the three year subsequent follow up, fails to support the hypothesis that mycobacteria play an important part in the pathogenesis of Crohn’s disease, or that antituberculous chemotherapy may be of benefit.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320174611461","@type":"Researcher","foaf:name":[{"@value":"G A O Thomas"}],"jpcoar:affiliationName":[{"@value":"aDepartment of Gastroenterology, University Hospital of Wales, Heath Park, Cardiff CF4 4XW, UK, \n\nbDepartment of Medical Computing and Statistics, University of Wales College of Medicine, Cardiff, UK, \n\ncDepartment of Gastroenterology, Llandough Hospital, Cardiff, UK, \n\ndDepartment of Medicine, Derriford Hopital, Plymouth, UK, \n\neHeinrich Heine Universität, Dusseldorf, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320174611460","@type":"Researcher","foaf:name":[{"@value":"G L Swift"}],"jpcoar:affiliationName":[{"@value":"aDepartment of Gastroenterology, University Hospital of Wales, Heath Park, Cardiff CF4 4XW, UK, \n\nbDepartment of Medical Computing and Statistics, University of Wales College of Medicine, Cardiff, UK, \n\ncDepartment of Gastroenterology, Llandough Hospital, Cardiff, UK, \n\ndDepartment of Medicine, Derriford Hopital, Plymouth, UK, \n\neHeinrich Heine Universität, Dusseldorf, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320174611462","@type":"Researcher","foaf:name":[{"@value":"J T Green"}],"jpcoar:affiliationName":[{"@value":"aDepartment of Gastroenterology, University Hospital of Wales, Heath Park, Cardiff CF4 4XW, UK, \n\nbDepartment of Medical Computing and Statistics, University of Wales College of Medicine, Cardiff, UK, \n\ncDepartment of Gastroenterology, Llandough Hospital, Cardiff, UK, \n\ndDepartment of Medicine, Derriford Hopital, Plymouth, UK, \n\neHeinrich Heine Universität, Dusseldorf, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320174611456","@type":"Researcher","foaf:name":[{"@value":"R G Newcombe"}],"jpcoar:affiliationName":[{"@value":"aDepartment of Gastroenterology, University Hospital of Wales, Heath Park, Cardiff CF4 4XW, UK, \n\nbDepartment of Medical Computing and Statistics, University of Wales College of Medicine, Cardiff, UK, \n\ncDepartment of Gastroenterology, Llandough Hospital, Cardiff, UK, \n\ndDepartment of Medicine, Derriford Hopital, Plymouth, UK, \n\neHeinrich Heine Universität, Dusseldorf, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320174611457","@type":"Researcher","foaf:name":[{"@value":"C Braniff-Mathews"}],"jpcoar:affiliationName":[{"@value":"aDepartment of Gastroenterology, University Hospital of Wales, Heath Park, Cardiff CF4 4XW, UK, \n\nbDepartment of Medical Computing and Statistics, University of Wales College of Medicine, Cardiff, UK, \n\ncDepartment of Gastroenterology, Llandough Hospital, Cardiff, UK, \n\ndDepartment of Medicine, Derriford Hopital, Plymouth, UK, \n\neHeinrich Heine Universität, Dusseldorf, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320174611463","@type":"Researcher","foaf:name":[{"@value":"J Rhodes"}],"jpcoar:affiliationName":[{"@value":"aDepartment of Gastroenterology, University Hospital of Wales, Heath Park, Cardiff CF4 4XW, UK, \n\nbDepartment of Medical Computing and Statistics, University of Wales College of Medicine, Cardiff, UK, \n\ncDepartment of Gastroenterology, Llandough Hospital, Cardiff, UK, \n\ndDepartment of Medicine, Derriford Hopital, Plymouth, UK, \n\neHeinrich Heine Universität, Dusseldorf, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320174611459","@type":"Researcher","foaf:name":[{"@value":"S Wilkinson"}],"jpcoar:affiliationName":[{"@value":"aDepartment of Gastroenterology, University Hospital of Wales, Heath Park, Cardiff CF4 4XW, UK, \n\nbDepartment of Medical Computing and Statistics, University of Wales College of Medicine, Cardiff, UK, \n\ncDepartment of Gastroenterology, Llandough Hospital, Cardiff, UK, \n\ndDepartment of Medicine, Derriford Hopital, Plymouth, UK, \n\neHeinrich Heine Universität, Dusseldorf, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320174611464","@type":"Researcher","foaf:name":[{"@value":"G Strohmeyer"}],"jpcoar:affiliationName":[{"@value":"aDepartment of Gastroenterology, University Hospital of Wales, Heath Park, Cardiff CF4 4XW, UK, \n\nbDepartment of Medical Computing and Statistics, University of Wales College of Medicine, Cardiff, UK, \n\ncDepartment of Gastroenterology, Llandough Hospital, Cardiff, UK, \n\ndDepartment of Medicine, Derriford Hopital, Plymouth, UK, \n\neHeinrich Heine Universität, Dusseldorf, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320174611458","@type":"Researcher","foaf:name":[{"@value":"G Kreuzpainter"}],"jpcoar:affiliationName":[{"@value":"aDepartment of Gastroenterology, University Hospital of Wales, Heath Park, Cardiff CF4 4XW, UK, \n\nbDepartment of Medical Computing and Statistics, University of Wales College of Medicine, Cardiff, UK, \n\ncDepartment of Gastroenterology, Llandough Hospital, Cardiff, UK, \n\ndDepartment of Medicine, Derriford Hopital, Plymouth, UK, \n\neHeinrich Heine Universität, Dusseldorf, Germany"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00175749"},{"@type":"EISSN","@value":"14683288"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00175749"}],"prism:publicationName":[{"@value":"Gut"}],"dc:publisher":[{"@value":"BMJ"}],"prism:publicationDate":"1998-04-01","prism:volume":"42","prism:number":"4","prism:startingPage":"497","prism:endingPage":"500"},"reviewed":"false","url":[{"@id":"https://syndication.highwire.org/content/doi/10.1136/gut.42.4.497"}],"createdAt":"2010-06-30","modifiedAt":"2025-12-06","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001204868228096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Role of Bacterial Infection in the Pathogenesis of Inflammatory Bowel Disease"},{"@language":"ja-Kana","@value":"Role of Bacterial Infection in the Pathogenesis of Inflammatory Bowel 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