{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320175177472.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/cncr.30135"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcncr.30135"}},{"identifier":{"@type":"URI","@value":"https://acsjournals.onlinelibrary.wiley.com/doi/pdf/10.1002/cncr.30135"}}],"dc:title":[{"@value":"Efficacy and safety of dovitinib in pretreated patients with advanced squamous non‐small cell lung cancer with <i>FGFR1</i> amplification: A single‐arm, phase 2 study"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec><jats:title>BACKGROUND</jats:title><jats:p>Fibroblast growth factor receptor 1 (<jats:italic>FGFR1</jats:italic>) amplification is a potential driving oncogene in squamous cell cancer (SCC) of the lung. The current phase 2 study evaluated the efficacy and tolerability of dovitinib, an FGFR inhibitor, in patients with advanced SCC of the lung.</jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p>Patients with pretreated advanced SCC of the lung whose tumors demonstrated <jats:italic>FGFR1</jats:italic> amplification of > 5 copies by fluorescence in situ hybridization were enrolled. Dovitinib at a dose of 500 mg was administered orally, once daily, on days 1 to 5 of every week, followed by 2 days off. The primary endpoint was overall response. Secondary endpoints were progression‐free survival, overall survival, and toxicity.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>All 26 patients were men with a median age of 68 years (range, 52‐80 years). The majority of patients were ever‐smokers. The median duration of dovitinib administration (28 days per cycle) was 2.5 months (range, 0.7‐8.6 months). The overall response rate was 11.5% (95% confidence interval [95% CI], 0.8%‐23.8%) and the disease control rate was 50% (95% CI, 30.8%‐69.2%), with 3 patients achieving partial responses. Response durations for the patients with partial responses were ≥4.5 months, ≥ 5.1 months, and 6.1 months, respectively. After a median follow‐up of 15.7 months (range, 1.2‐25.6 months), the median overall survival was 5.0 months (95% CI, 3.6‐6.4 months) and the median progression‐free survival was 2.9 months (95% CI, 1.5‐4.3 months). The most common grade 3 or higher adverse events were fatigue (19.2%), anorexia (11.5%), and hyponatremia (11.5%) (event severity was graded based on National Cancer Institute Common Terminology Criteria for Adverse Events [version 4.0]).</jats:p></jats:sec><jats:sec><jats:title>CONCLUSIONS</jats:title><jats:p>Treatment with dovitinib demonstrated modest efficacy in patients with advanced SCC with <jats:italic>FGFR1</jats:italic> amplification. Further studies to evaluate other biomarkers correlated with the efficacy of dovitinib in patients with SCC are warranted. <jats:bold><jats:italic>Cancer</jats:italic> 2016;122:3024‐3031</jats:bold>. © <jats:italic>2016 American Cancer Society</jats:italic>.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320175177472","@type":"Researcher","foaf:name":[{"@value":"Sung Hee Lim"}],"jpcoar:affiliationName":[{"@value":"Division of Hematology‐Oncology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298344258973314","@type":"Researcher","foaf:name":[{"@value":"Jong‐Mu Sun"}],"jpcoar:affiliationName":[{"@value":"Division of Hematology‐Oncology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320175177348","@type":"Researcher","foaf:name":[{"@value":"Hye Ryun Kim"}],"jpcoar:affiliationName":[{"@value":"Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center Yonsei University College of Medicine Seoul South Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320175177473","@type":"Researcher","foaf:name":[{"@value":"Soomin Ahn"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Translational Genomics, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298344258973313","@type":"Researcher","foaf:name":[{"@value":"Yoon‐La Choi"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Translational Genomics, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320175177477","@type":"Researcher","foaf:name":[{"@value":"Ji Yun Lee"}],"jpcoar:affiliationName":[{"@value":"Division of Hematology‐Oncology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298344258973184","@type":"Researcher","foaf:name":[{"@value":"Se‐Hoon Lee"}],"jpcoar:affiliationName":[{"@value":"Division of Hematology‐Oncology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320175177346","@type":"Researcher","foaf:name":[{"@value":"Jin Seok Ahn"}],"jpcoar:affiliationName":[{"@value":"Division of Hematology‐Oncology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298344258973312","@type":"Researcher","foaf:name":[{"@value":"Myung‐Ju Ahn"}],"jpcoar:affiliationName":[{"@value":"Division of Hematology‐Oncology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320175177345","@type":"Researcher","foaf:name":[{"@value":"Keunchil Park"}],"jpcoar:affiliationName":[{"@value":"Division of Hematology‐Oncology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320175177476","@type":"Researcher","foaf:name":[{"@value":"Byoung Chul Cho"}],"jpcoar:affiliationName":[{"@value":"Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center Yonsei University College of Medicine Seoul South Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320175177478","@type":"Researcher","foaf:name":[{"@value":"Joo Hang Kim"}],"jpcoar:affiliationName":[{"@value":"Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center Yonsei University College of Medicine Seoul South Korea"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0008543X"},{"@type":"EISSN","@value":"10970142"}],"prism:publicationName":[{"@value":"Cancer"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2016-06-17","prism:volume":"122","prism:number":"19","prism:startingPage":"3024","prism:endingPage":"3031"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcncr.30135"},{"@id":"https://acsjournals.onlinelibrary.wiley.com/doi/pdf/10.1002/cncr.30135"}],"createdAt":"2016-06-17","modifiedAt":"2025-10-12","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004234551932032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Resistance mediated by alternative receptor tyrosine kinases in FGFR1-amplified lung cancer"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/cncr.30135"},{"@type":"CROSSREF","@value":"10.1093/carcin/bgx091_references_DOI_2xl1nlZxOlQFyMbyUatsgAFRoBt"}]}