{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320184535168.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/gcc.20214"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fgcc.20214"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/gcc.20214"}}],"dc:title":[{"@value":"<i>PAX5/IGH</i> rearrangement is a recurrent finding in a subset of aggressive B‐NHL with complex chromosomal rearrangements"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>We present an extensive characterization of 10 B‐cell lymphomas with a t(9;14)(p13;q32). The presence of the <jats:italic>PAX5/IGH</jats:italic> gene rearrangement was demonstrated by fluorescence in situ hybridization (FISH) using a validated probe set, whereas complex karyotypic changes were reassessed by multiplex‐FISH (M‐FISH). Pathologic and clinical review revealed the presence of this rearrangement in 4 histiocyte‐rich, T‐cell‐rich B‐cell lymphomas (HRTR‐BCLs) and 2 posttransplantation diffuse large B‐cell lymphomas (PTLD‐DLBCLs). In contrast to initial observations describing this translocation in lymphoplasmacytic lymphoma (LPL) and LPL‐derived large B‐cell lymphoma, our data showed a wide morphologic and clinical spectrum associated with the <jats:italic>PAX5/IGH</jats:italic> rearrangement, pointing to an association between this aberration and a subset of de novo DLBCLs presenting with advanced disease and adverse prognosis. In addition, the recurrent incidence of this rearrangement in both HRTR‐BCL (4 cases) and PTLD‐DLBCL (2 cases) was previously unrecognized and is intriguing. © 2005 Wiley‐Liss, Inc.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320184535174","@type":"Researcher","foaf:name":[{"@value":"Bruce Poppe"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320184535181","@type":"Researcher","foaf:name":[{"@value":"Pascale De Paepe"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320184535180","@type":"Researcher","foaf:name":[{"@value":"Lucienne Michaux"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320184535168","@type":"Researcher","foaf:name":[{"@value":"Nicole Dastugue"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320184535175","@type":"Researcher","foaf:name":[{"@value":"Christian Bastard"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320184535176","@type":"Researcher","foaf:name":[{"@value":"Christian Herens"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320184535182","@type":"Researcher","foaf:name":[{"@value":"Els Moreau"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320184535170","@type":"Researcher","foaf:name":[{"@value":"Francesco Cavazzini"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320184535169","@type":"Researcher","foaf:name":[{"@value":"Nurten Yigit"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320184535172","@type":"Researcher","foaf:name":[{"@value":"Heidi Van Limbergen"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320184535178","@type":"Researcher","foaf:name":[{"@value":"Anne De Paepe"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320184535171","@type":"Researcher","foaf:name":[{"@value":"Marleen Praet"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016867242226560","@type":"Researcher","foaf:name":[{"@value":"Chris De Wolf‐Peeters"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320184535173","@type":"Researcher","foaf:name":[{"@value":"Iwona Wlodarska"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320184535177","@type":"Researcher","foaf:name":[{"@value":"Frank Speleman"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10452257"},{"@type":"EISSN","@value":"10982264"}],"prism:publicationName":[{"@value":"Genes, Chromosomes and Cancer"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2005-06-07","prism:volume":"44","prism:number":"2","prism:startingPage":"218","prism:endingPage":"223"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fgcc.20214"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/gcc.20214"}],"createdAt":"2005-06-07","modifiedAt":"2023-10-16","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004233414665984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Transcriptional suppression of BACH2 by the Bcr-Abl oncoprotein is mediated by PAX5"}]},{"@id":"https://cir.nii.ac.jp/crid/1390009018098626816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"t(9;14)(p13;q32)/<i>PAX5</i>-IGH translocation as a secondary cytogenetic abnormality in diffuse large B-cell lymphoma"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/gcc.20214"},{"@type":"CROSSREF","@value":"10.1038/leu.2012.220_references_DOI_WZgsR3Z1YuJhTOvD3zR2IQM0ugr"},{"@type":"CROSSREF","@value":"10.3960/jslrt.21025_references_DOI_WZgsR3Z1YuJhTOvD3zR2IQM0ugr"}]}