{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320196757120.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1136/heart.85.1.30"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1136/heart.85.1.30"}}],"dc:title":[{"@value":"Assessment of left ventricular long axis contraction can detect early myocardial dysfunction in asymptomatic patients with severe aortic regurgitation"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec>\n                  <jats:title>OBJECTIVE</jats:title>\n                  <jats:p>To identify variables that could be applied at rest to diagnose subclinical ventricular dysfunction in asymptomatic patients with severe aortic regurgitation.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>DESIGN</jats:title>\n                  <jats:p>Cross sectional study.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>PATIENTS</jats:title>\n                  <jats:p>Left ventricular long axis contraction was studied using tissue Doppler and M mode echocardiography in 21 patients with no symptoms (New York Heart Association (NYHA) functional class ⩽ 2a) but severe aortic regurgitation (jet area/left ventricular outflow tract area > 40%).</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN OUTCOME MEASURES</jats:title>\n                  <jats:p>Left ventricular ejection fraction (LVEF) at baseline and peak exercise (Weber protocol), cardiopulmonary function, and left ventricular long axis function at rest (peak systolic velocity and excursion of the mitral annulus).</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS</jats:title>\n                  <jats:p>In 11 patients, ejection fraction increased or did not change (from mean (SD) 55 (5)% to 58 (4)%, p < 0.05) (group I); in 10 patients it decreased by > 5% (from 54 (4)% to 42 (5)%, p < 0.001) (group II). Exercise ejection fraction was < 50% in all patients in group II. At rest, there were no differences between the groups in ejection fraction, left ventricular diameter indices, wall stress, and short axis contraction. However, patients in group II had reduced long axis contraction compared with group I: peak systolic velocity 8.6 (0.6)<jats:italic>v</jats:italic> 11.9 (2.2) cm/s (p < 0.001); excursion 11 (2) <jats:italic>v</jats:italic> 14 (2) mm (p < 0.01). A resting velocity of < 9.5 cm/s was the best indicator of poor exercise tolerance (sensitivity 90%, specificity 100%).</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS</jats:title>\n                  <jats:p>Markers of reduced long axis contraction may provide simple and reliable indices of subclinical left ventricular dysfunction in asymptomatic patients with severe aortic regurgitation.</jats:p>\n               </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380567181146232835","@type":"Researcher","foaf:name":[{"@value":"D Vinereanu"}],"jpcoar:affiliationName":[{"@value":"Cardiovascular Sciences Research Group, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869456648410880","@type":"Researcher","foaf:name":[{"@value":"A A Ionescu"}],"jpcoar:affiliationName":[{"@value":"Cardiovascular Sciences Research Group, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869456648410881","@type":"Researcher","foaf:name":[{"@value":"A G Fraser"}],"jpcoar:affiliationName":[{"@value":"Cardiovascular Sciences Research Group, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13556037"},{"@type":"EISSN","@value":"1468201X"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/00070769"}],"prism:publicationName":[{"@value":"Heart"}],"dc:publisher":[{"@value":"BMJ"}],"prism:publicationDate":"2001-01-01","prism:volume":"85","prism:number":"1","prism:startingPage":"30","prism:endingPage":"36"},"reviewed":"false","url":[{"@id":"https://syndication.highwire.org/content/doi/10.1136/heart.85.1.30"}],"createdAt":"2002-07-27","modifiedAt":"2025-09-21","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285710592021120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Increased plasma type B natriuretic peptide in the acute phase of Kawasaki disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181146232832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cardiac β-adrenergic receptor density and myocardial systolic function in the remote noninfarcted region after prior myocardial infarction with left ventricular remodelling"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205104350976","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Subclinical Left Ventricular Longitudinal Systolic Dysfunction in Hypertension With No Evidence of Heart Failure"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205105819008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Abnormal Tissue Doppler Images are Associated With Elevated Plasma Brain Natriuretic Peptide and Increased Oxidative Stress in Acute Kawasaki Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680081702400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Transition From Asymptomatic Diastolic Dysfunction to Heart Failure With Preserved Ejection Fraction  - Roles of Systolic Function and Ventricular Distensibility -"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1136/heart.85.1.30"},{"@type":"CROSSREF","@value":"10.1253/circj.72.189_references_DOI_9mqigVeovX6UWFP5yvIP8D48noE"},{"@type":"CROSSREF","@value":"10.1111/j.1442-200x.2011.03351.x_references_DOI_9mqigVeovX6UWFP5yvIP8D48noE"},{"@type":"CROSSREF","@value":"10.1007/s00259-012-2138-4_references_DOI_9mqigVeovX6UWFP5yvIP8D48noE"},{"@type":"CROSSREF","@value":"10.1253/circj.71.357_references_DOI_9mqigVeovX6UWFP5yvIP8D48noE"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-10-1037_references_DOI_9mqigVeovX6UWFP5yvIP8D48noE"}]}