{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320200213504.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s41598-019-46120-z"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41598-019-46120-z.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41598-019-46120-z"}}],"dc:title":[{"@value":"Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Nicotinamide riboside (NR) is a newly discovered nicotinamide adenine dinucleotide (NAD<jats:sup>+</jats:sup>) precursor vitamin. A crystal form of NR chloride termed NIAGEN is generally recognized as safe (GRAS) for use in foods and the subject of two New Dietary Ingredient Notifications for use in dietary supplements. To evaluate the kinetics and dose-dependency of NR oral availability and safety in overweight, but otherwise healthy men and women, an 8-week randomized, double-blind, placebo-controlled clinical trial was conducted. Consumption of 100, 300 and 1000 mg NR dose-dependently and significantly increased whole blood NAD<jats:sup>+</jats:sup> (i.e., 22%, 51% and 142%) and other NAD<jats:sup>+</jats:sup> metabolites within 2 weeks. The increases were maintained throughout the remainder of the study. There were no reports of flushing and no significant differences in adverse events between the NR and placebo-treated groups or between groups at different NR doses. NR also did not elevate low density lipoprotein cholesterol or dysregulate 1-carbon metabolism. Together these data support the development of a tolerable upper intake limit for NR based on human data.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320200213506","@type":"Researcher","foaf:name":[{"@value":"Dietrich Conze"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320200213505","@type":"Researcher","foaf:name":[{"@value":"Charles Brenner"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320200213504","@type":"Researcher","foaf:name":[{"@value":"Claire L. Kruger"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20452322"}],"prism:publicationName":[{"@value":"Scientific Reports"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2019-07-05","prism:volume":"9","prism:number":"1","prism:startingPage":"9772"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/s41598-019-46120-z.pdf"},{"@id":"https://www.nature.com/articles/s41598-019-46120-z"}],"createdAt":"2019-07-05","modifiedAt":"2022-12-17","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360013168821081856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016866458247808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017279870925312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Interactions between Intestinal Homeostasis and NAD+ Biology in Regulating Incretin Production and Postprandial Glucose Metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298337115971200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865734740096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"NAD\n                    <sup>+</sup>\n                    Precursors in Human Health and Disease: Current Status and Future Prospects"}]},{"@id":"https://cir.nii.ac.jp/crid/1360568470730653184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impaired nicotinamide adenine dinucleotide (NAD<sup>+</sup>) metabolism in diabetes and diabetic tissues: Implications for nicotinamide‐related compound treatment"}]},{"@id":"https://cir.nii.ac.jp/crid/1390285697589711616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Potential significance of NAD<sup>+</sup> biology translational research in super-aged Japan"},{"@language":"ja","@value":"超高齢社会日本におけるNAD<sup>＋</sup>生物学トランスレーショナル研究の意義と可能性"},{"@value":"超高齢社会日本におけるNAD⁺生物学トランスレーショナル研究の意義と可能性"},{"@language":"ja-Kana","@value":"チョウコウレイ シャカイ ニホン ニ オケル NAD ⁺ セイブツガク トランスレーショナル ケンキュウ ノ イギ ト カノウセイ"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/s41598-019-46120-z"},{"@type":"CROSSREF","@value":"10.1038/s41467-021-27080-3_references_DOI_PVcoOAR9cjVnIYyBjtL4fEaRgiP"},{"@type":"CROSSREF","@value":"10.1038/s41514-022-00084-z_references_DOI_PVcoOAR9cjVnIYyBjtL4fEaRgiP"},{"@type":"CROSSREF","@value":"10.3390/nu15061494_references_DOI_PVcoOAR9cjVnIYyBjtL4fEaRgiP"},{"@type":"CROSSREF","@value":"10.3389/fnut.2022.868640_references_DOI_PVcoOAR9cjVnIYyBjtL4fEaRgiP"},{"@type":"CROSSREF","@value":"10.1089/ars.2023.0354_references_DOI_PVcoOAR9cjVnIYyBjtL4fEaRgiP"},{"@type":"CROSSREF","@value":"10.3143/geriatrics.57.213_references_DOI_PVcoOAR9cjVnIYyBjtL4fEaRgiP"},{"@type":"CROSSREF","@value":"10.1111/jdi.13303_references_DOI_PVcoOAR9cjVnIYyBjtL4fEaRgiP"}]}