{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320250382976.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1039/c1nr10635j"}},{"identifier":{"@type":"URI","@value":"http://pubs.rsc.org/en/content/articlepdf/2011/NR/C1NR10635J"}},{"identifier":{"@type":"PMID","@value":"21931919"}}],"dc:title":[{"@value":"Enhanced cell uptake via non-covalent decollation of a single-walled carbon nanotube-DNA hybrid with polyethylene glycol-grafted poly(l-lysine) labeled with an Alexa-dye and its efficient uptake in a cancer cell"}],"description":[{"notation":[{"@value":"The use of single-walled carbon nanotubes (SWNTs) for biomedical applications is a promising approach due to their unique outer optical stimuli response properties, such as a photothermal response triggered by near-IR laser irradiation. The challenging task in order to realize such applications is to render the SWNTs biocompatible. For this purpose, the stable and homogeneous functionalization of the SWNTs with a molecule carrying a biocompatible group is very important. Here, we describe the design and synthesis of a polyanionic SWNT/DNA hybrid combined with a cationic poly(l-lysine) grafted by polyethylene glycol (PLL-g-PEG) to provide a supramolecular SWNT assembly. A titration experiment revealed that the assembly undergoes an approximately 1 : 1 reaction of the SWNT/DNA with PLL-g-PEG. We also found that SWNT/DNA is coated with PLL-g-PEG very homogeneously that avoids the non-specific binding of proteins on the SWNT surface. The experiment using the obtained supramolecular hybrid was carried out in vitro and a dramatic enhancement in the cell uptake efficiency compared to that of the SWNT/DNA hybrid without PLL-g-PEG was found."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420564276161880192","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30444863"},{"@type":"NRID","@value":"1000030444863"},{"@type":"NRID","@value":"9000253029910"},{"@type":"NRID","@value":"9000401999601"},{"@type":"NRID","@value":"9000398968432"},{"@type":"NRID","@value":"9000009565816"},{"@type":"NRID","@value":"9000391611885"},{"@type":"NRID","@value":"9000259831948"},{"@type":"NRID","@value":"9000009746552"},{"@type":"NRID","@value":"9000310734896"},{"@type":"NRID","@value":"9000017037490"},{"@type":"NRID","@value":"9000252776359"},{"@type":"NRID","@value":"9000401711771"},{"@type":"NRID","@value":"9000283254561"},{"@type":"NRID","@value":"9000002024261"},{"@type":"NRID","@value":"9000317153371"},{"@type":"NRID","@value":"9000010735821"},{"@type":"NRID","@value":"9000006481944"},{"@type":"NRID","@value":"9000391523552"},{"@type":"NRID","@value":"9000401798732"},{"@type":"NRID","@value":"9000383164062"},{"@type":"NRID","@value":"9000413357879"},{"@type":"NRID","@value":"9000398251098"},{"@type":"NRID","@value":"9000257733975"},{"@type":"NRID","@value":"9000257727498"},{"@type":"NRID","@value":"9000408451451"},{"@type":"NRID","@value":"9000017550851"},{"@type":"NRID","@value":"9000403427813"},{"@type":"NRID","@value":"9000009565326"},{"@type":"NRID","@value":"9000265565314"},{"@type":"NRID","@value":"9000253030651"},{"@type":"NRID","@value":"9000401800551"},{"@type":"NRID","@value":"9000399768643"},{"@type":"NRID","@value":"9000308382973"},{"@type":"NRID","@value":"9000315152144"},{"@type":"NRID","@value":"9000405705032"},{"@type":"NRID","@value":"9000382228946"},{"@type":"NRID","@value":"9000257895828"},{"@type":"NRID","@value":"9000257738264"},{"@type":"NRID","@value":"9000387496779"},{"@type":"NRID","@value":"9000283391351"},{"@type":"NRID","@value":"9000000356483"},{"@type":"NRID","@value":"9000283911908"},{"@type":"NRID","@value":"9000345260645"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/fujigaya.tsuyohiko"}],"foaf:name":[{"@value":"Tsuyohiko Fujigaya"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320250382978","@type":"Researcher","foaf:name":[{"@value":"Yuki Yamamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320250382976","@type":"Researcher","foaf:name":[{"@value":"Arihiro Kano"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320250383104","@type":"Researcher","foaf:name":[{"@value":"Atsushi Maruyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320250382977","@type":"Researcher","foaf:name":[{"@value":"Naotoshi Nakashima"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"20403364"},{"@type":"EISSN","@value":"20403372"}],"prism:publicationName":[{"@value":"Nanoscale"}],"dc:publisher":[{"@value":"Royal Society of Chemistry (RSC)"}],"prism:publicationDate":"2011","prism:volume":"3","prism:number":"10","prism:startingPage":"4352"},"reviewed":"false","url":[{"@id":"http://pubs.rsc.org/en/content/articlepdf/2011/NR/C1NR10635J"}],"createdAt":"2011-09-20","modifiedAt":"2024-04-17","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Nanotubes,%20Carbon","dc:title":"Nanotubes, Carbon"},{"@id":"https://cir.nii.ac.jp/all?q=DNA","dc:title":"DNA"},{"@id":"https://cir.nii.ac.jp/all?q=Microscopy,%20Atomic%20Force","dc:title":"Microscopy, Atomic Force"},{"@id":"https://cir.nii.ac.jp/all?q=Spectrum%20Analysis,%20Raman","dc:title":"Spectrum Analysis, Raman"},{"@id":"https://cir.nii.ac.jp/all?q=Polyethylene%20Glycols","dc:title":"Polyethylene Glycols"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line,%20Tumor","dc:title":"Cell Line, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasms","dc:title":"Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Polylysine","dc:title":"Polylysine"},{"@id":"https://cir.nii.ac.jp/all?q=Fluorescent%20Dyes","dc:title":"Fluorescent Dyes"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004239509875968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hybrids of Nucleic Acids and Carbon Nanotubes  for Nanobiotechnology"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706164985600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Physisorption of DNA molecules on chemically modified single-walled carbon nanotubes with and without sonication"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298341433060352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Protein-structure-dependent spectral shifts of near-infrared photoluminescence from locally functionalized single-walled carbon nanotubes based on avidin–biotin interactions"}]},{"@id":"https://cir.nii.ac.jp/crid/2120589364498127872","@type":"OtherWorks","resourceType":"学術雑誌論文(journal article)","relationType":["isIdenticalTo"],"jpcoar:relatedTitle":[{"@value":"Enhanced cell uptake via non-covalent decollation of a single-walled carbon nanotube-DNA hybrid with polyethylene glycol-grafted poly(l-lysine) labeled with an Alexa-dye and its efficient uptake in a cancer cell"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1039/c1nr10635j"},{"@type":"OPENAIRE","@value":"doi_dedup___::5e4869289cb8eb73f7da9ce9d088762b"},{"@type":"IRDB","@value":"oai:irdb.nii.ac.jp:00897:0004324644_isIdenticalTo_DOI_FS3Qc1vgjRXS4VeopkgMyAYi3NM"},{"@type":"CROSSREF","@value":"10.3390/nano5010321_references_DOI_XHfGn5vW0IvvifQrxqEZATmKKXP"},{"@type":"CROSSREF","@value":"10.1039/d2nr01440h_references_DOI_XHfGn5vW0IvvifQrxqEZATmKKXP"},{"@type":"CROSSREF","@value":"10.1007/s00249-016-1116-3_references_DOI_XHfGn5vW0IvvifQrxqEZATmKKXP"}]}